Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells
10.1126/science.274.5288.792
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The outermost layer of the human placenta is devoid of classical class I human leukocyte antigens (HLA-A, HLA-B, and HLA-C) and class II proteins (HLA-DR, HLA-DQ, and HLA-DP). Although this prevents recognition by maternal T lymphocytes, the lack of class I molecules leaves these cells susceptible to attack by natural killer (NK) cells. However, trophoblast cells directly in contact with the maternal tissues express the class I molecule HLA-G, which may be involved in protecting the trophoblast from recognition by NK cells. Here evidence is provided that expression of HLA-G is sufficient to protect otherwise susceptible target cells from lysis by activated NK1 and NK2 cell lines and clones that are specific for distinct groups of HLA-C alleles. The receptors on NK cells that recognize HLA-G are also identified.

Bibliography

Pazmany, L., Mandelboim, O., Valés-Gómez, M., Davis, D. M., Reyburn, H. T., & Strominger, J. L. (1996). Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells. Science, 274(5288), 792–795.

Authors 6
  1. Laszlo Pazmany (first)
  2. Ofer Mandelboim (additional)
  3. Mar Valés-Gómez (additional)
  4. Daniel M. Davis (additional)
  5. Hugh T. Reyburn (additional)
  6. Jack L. Strominger (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 5:50 a.m.)
Deposited 1 year ago (Aug. 7, 2024, 7:30 a.m.)
Indexed 1 week, 2 days ago (Aug. 23, 2025, 12:59 a.m.)
Issued 28 years, 10 months ago (Nov. 1, 1996)
Published 28 years, 10 months ago (Nov. 1, 1996)
Published Print 28 years, 10 months ago (Nov. 1, 1996)
Funders 0

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@article{Pazmany_1996, title={Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells}, volume={274}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.274.5288.792}, DOI={10.1126/science.274.5288.792}, number={5288}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pazmany, Laszlo and Mandelboim, Ofer and Valés-Gómez, Mar and Davis, Daniel M. and Reyburn, Hugh T. and Strominger, Jack L.}, year={1996}, month=nov, pages={792–795} }