Crossref
journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract
The Tax transactivator of the human T cell leukemia virus type I (HTLV-I) exhibits oncogenic properties. A screen for proteins interacting with Tax yielded a complementary DNA (cDNA) encoding the human Int-6 protein. In mice, the Int-6 gene can be converted into a putative dominant negative oncogene after retroviral insertion. Here, Int-6 was localized in the cell nucleus to give a speckled staining pattern superposed to that of the promyelocytic leukemia (PML) protein. The binding of Tax to Int-6 caused its redistribution from the nuclear domains to the cytoplasm. Thus, Int-6 is a component of the PML nuclear bodies and Tax disrupts its normal cellular localization by binding to it.
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Dates
| Type | When |
|---|---|
| Created | 18 years, 10 months ago (Oct. 27, 2006, 10:30 a.m.) |
| Deposited | 1 year, 7 months ago (Jan. 12, 2024, 6:15 p.m.) |
| Indexed | 2 months, 3 weeks ago (June 11, 2025, 5:29 a.m.) |
| Issued | 29 years ago (Aug. 16, 1996) |
| Published | 29 years ago (Aug. 16, 1996) |
| Published Print | 29 years ago (Aug. 16, 1996) |
@article{Desbois_1996, title={Exclusion of Int-6 from PML Nuclear Bodies by Binding to the HTLV-I Tax Oncoprotein}, volume={273}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.273.5277.951}, DOI={10.1126/science.273.5277.951}, number={5277}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Desbois, Christelle and Rousset, Raphaël and Bantignies, Frédéric and Jalinot, Pierre}, year={1996}, month=aug, pages={951–953} }