DOI: 10.1126/science.272.5270.1904. Tickling Memory T Cells

10.1126/science.272.5270.1904

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Viruses cause immediate induction of type I interferons (which include IFN-alpha and IFN-beta). These IFN I cytokines limit spread of the virus until antigen-specific responses can fully control the infection. A report by Tough et al . ( p. 1947 ) show that these IFN I have another function: They also augment the proliferation of T cells, including a subset of T cells that may mediate long-term immunological memory. In his Perspective, Ahmed discusses the possible contribution of this bystander effect of IFN I to immunological memory.

Bibliography

Ahmed, R. (1996). Tickling Memory T Cells. Science, 272(5270), 1904â1904.

Authors 1

Rafi Ahmed (first)

References 23 Referenced 22

10.1126/science.272.5258.54
ASANO M.S., CD8 T cell memory in B cell-deficient mice, JOURNAL OF EXPERIMENTAL MEDICINE 183, 2165 (1996). (10.1084/jem.183.5.2165) / JOURNAL OF EXPERIMENTAL MEDICINE / CD8 T cell memory in B cell-deficient mice by ASANO M.S. (1996)
BEVERLEY PCL, IS T-CELL MEMORY MAINTAINED BY CROSS-REACTIVE STIMULATION, IMMUNOLOGY TODAY 11, 203 (1990). (10.1016/0167-5699(90)90083-L) / IMMUNOLOGY TODAY / IS T-CELL MEMORY MAINTAINED BY CROSS-REACTIVE STIMULATION by BEVERLEY PCL (1990)
BIRON C.A., INTERFERON INDUCES NATURAL-KILLER CELL BLASTOGENESIS INVIVO, JOURNAL OF LEUKOCYTE BIOLOGY 35, 31 (1984). (10.1002/jlb.35.1.31) / JOURNAL OF LEUKOCYTE BIOLOGY / INTERFERON INDUCES NATURAL-KILLER CELL BLASTOGENESIS INVIVO by BIRON C.A. (1984)
BRUNO L, ON THE CELLULAR BASIS OF IMMUNOLOGICAL T-CELL MEMORY, IMMUNITY 2, 37 (1995). (10.1016/1074-7613(95)90077-2) / IMMUNITY / ON THE CELLULAR BASIS OF IMMUNOLOGICAL T-CELL MEMORY by BRUNO L (1995)
CAO W.X., PARTIAL ACTIVATION OF CD8(+) T-CELLS BY A SELF-DERIVED PEPTIDE, NATURE 378, 295 (1995). (10.1038/378295a0) / NATURE / PARTIAL ACTIVATION OF CD8(+) T-CELLS BY A SELF-DERIVED PEPTIDE by CAO W.X. (1995)
DEGRE M, INFLUENCE OF EXOGENOUS INTERFERON ON PERIPHERAL WHITE BLOOD-CELL COUNT IN MICE, INTERNATIONAL JOURNAL OF CANCER 14, 699 (1974). (10.1002/ijc.2910140602) / INTERNATIONAL JOURNAL OF CANCER / INFLUENCE OF EXOGENOUS INTERFERON ON PERIPHERAL WHITE BLOOD-CELL COUNT IN MICE by DEGRE M (1974)
10.1126/science.272.5258.50
GIDLUND M, ENHANCED NK CELL ACTIVITY IN MICE INJECTED WITH INTERFERON AND INTERFERON INDUCERS, NATURE 273, 759 (1978). (10.1038/273759a0) / NATURE / ENHANCED NK CELL ACTIVITY IN MICE INJECTED WITH INTERFERON AND INTERFERON INDUCERS by GIDLUND M (1978)
GRESSER I, INTERFERON INDUCES PERIPHERAL LYMPHADENOPATHY IN MICE, JOURNAL OF IMMUNOLOGY 127, 1569 (1981). (10.4049/jimmunol.127.4.1569) / JOURNAL OF IMMUNOLOGY / INTERFERON INDUCES PERIPHERAL LYMPHADENOPATHY IN MICE by GRESSER I (1981)
10.1038/369652a0
ISHIKAWA R, IFN INDUCTION AND ASSOCIATED CHANGES IN SPLENIC LEUKOCYTE DISTRIBUTION, JOURNAL OF IMMUNOLOGY 150, 3713 (1993). (10.4049/jimmunol.150.9.3713) / JOURNAL OF IMMUNOLOGY / IFN INDUCTION AND ASSOCIATED CHANGES IN SPLENIC LEUKOCYTE DISTRIBUTION by ISHIKAWA R (1993)
KORNGOLD R, EFFECT OF INTERFERON ON THORACIC-DUCT LYMPHOCYTE OUTPUT - INDUCTION WITH EITHER POLY-I-POLY-C OR VACCINIA VIRUS, JOURNAL OF IMMUNOLOGY 130, 2236 (1983). (10.4049/jimmunol.130.5.2236) / JOURNAL OF IMMUNOLOGY / EFFECT OF INTERFERON ON THORACIC-DUCT LYMPHOCYTE OUTPUT - INDUCTION WITH EITHER POLY-I-POLY-C OR VACCINIA VIRUS by KORNGOLD R (1983)
10.1038/369648a0
MATZINGER P, IMMUNOLOGY - MEMORIES ARE MADE OF THIS, NATURE 369, 605 (1994). (10.1038/369605a0) / NATURE / IMMUNOLOGY - MEMORIES ARE MADE OF THIS by MATZINGER P (1994)
MULLBACHER A, THE LONG-TERM MAINTENANCE OF CYTOTOXIC T-CELL MEMORY DOES NOT REQUIRE PERSISTENCE OF ANTIGEN, JOURNAL OF EXPERIMENTAL MEDICINE 179, 317 (1994). (10.1084/jem.179.1.317) / JOURNAL OF EXPERIMENTAL MEDICINE / THE LONG-TERM MAINTENANCE OF CYTOTOXIC T-CELL MEMORY DOES NOT REQUIRE PERSISTENCE OF ANTIGEN by MULLBACHER A (1994)
10.1126/science.8009221
10.1126/science.272.5270.1947
UNUTMAZ D, ANTIGEN-INDEPENDENT ACTIVATION OF NAIVE AND MEMORY RESTING T-CELLS BY A CYTOKINE COMBINATION, JOURNAL OF EXPERIMENTAL MEDICINE 180, 1159 (1994). (10.1084/jem.180.3.1159) / JOURNAL OF EXPERIMENTAL MEDICINE / ANTIGEN-INDEPENDENT ACTIVATION OF NAIVE AND MEMORY RESTING T-CELLS BY A CYTOKINE COMBINATION by UNUTMAZ D (1994)
VILCEK J, FIELDS VIROLOGY: 375 (1996). / FIELDS VIROLOGY by VILCEK J (1996)
WELSH R.M., Lymphocyte-dependent “natural” immunity to virus infections mediated by both natural killer cells and memory T cells, SEMINARS IN VIROLOGY 7, 95 (1996). (10.1006/smvy.1996.0012) / SEMINARS IN VIROLOGY / Lymphocyte-dependent “natural” immunity to virus infections mediated by both natural killer cells and memory T cells by WELSH R.M. (1996)
ZIMMERMANN C, Visualization, characterization, and turnover of CD8(+) memory T cells in virus-infected hosts, JOURNAL OF EXPERIMENTAL MEDICINE 183, 1367 (1996). (10.1084/jem.183.4.1367) / JOURNAL OF EXPERIMENTAL MEDICINE / Visualization, characterization, and turnover of CD8(+) memory T cells in virus-infected hosts by ZIMMERMANN C (1996)
10.1126/science.271.5246.173

Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 9:59 p.m.)
Indexed	1 year, 7 months ago (Jan. 13, 2024, 5:55 a.m.)
Issued	29 years, 2 months ago (June 28, 1996)
Published	29 years, 2 months ago (June 28, 1996)
Published Print	29 years, 2 months ago (June 28, 1996)

Funders 0

None

BibTeX

@article{Ahmed_1996, title={Tickling Memory T Cells}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5270.1904}, DOI={10.1126/science.272.5270.1904}, number={5270}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ahmed, Rafi}, year={1996}, month=jun, pages={1904–1904} }

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