Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
10.1126/science.272.5268.1668
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the most common human cancer. Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene. The ptc gene encodes a transmembrane protein that in Drosophila acts in opposition to the Hedgehog signaling protein, controlling cell fates, patterning, and growth in numerous tissues. The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression.

Bibliography

Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H., & Scott, M. P. (1996). Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome. Science, 272(5268), 1668–1671.

Authors 11
  1. Ronald L. Johnson (first)
  2. Alana L. Rothman (additional)
  3. Jingwu Xie (additional)
  4. Lisa V. Goodrich (additional)
  5. John W. Bare (additional)
  6. Jeannette M. Bonifas (additional)
  7. Anthony G. Quinn (additional)
  8. Richard M. Myers (additional)
  9. David R. Cox (additional)
  10. Ervin H. Epstein (additional)
  11. Matthew P. Scott (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 9:46 p.m.)
Indexed 1 day, 15 hours ago (Aug. 29, 2025, 6:38 a.m.)
Issued 29 years, 2 months ago (June 14, 1996)
Published 29 years, 2 months ago (June 14, 1996)
Published Print 29 years, 2 months ago (June 14, 1996)
Funders 0

None

@article{Johnson_1996, title={Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5268.1668}, DOI={10.1126/science.272.5268.1668}, number={5268}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Johnson, Ronald L. and Rothman, Alana L. and Xie, Jingwu and Goodrich, Lisa V. and Bare, John W. and Bonifas, Jeannette M. and Quinn, Anthony G. and Myers, Richard M. and Cox, David R. and Epstein, Ervin H. and Scott, Matthew P.}, year={1996}, month=jun, pages={1668–1671} }