DOI: 10.1126/science.272.5264.1020. Binding of APC to the Human Homolog of the <b> <i>Drosophila</i> </b> Discs Large Tumor Suppressor Protein

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

10.1126/science.272.5264.1020

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The adenomatous polyposis coli gene ( APC ) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein β-catenin. Overexpression of APC blocks cell cycle progression. The APC-β-catenin complex was shown to bind to DLG, the human homolog of the Drosophila discs large tumor suppressor protein. This interaction required the carboxyl-terminal region of APC and the DLG homology repeat region of DLG. APC colocalized with DLG at the lateral cytoplasm in rat colon epithelial cells and at the synapse in cultured hippocampal neurons. These results suggest that the APC-DLG complex may participate in regulation of both cell cycle progression and neuronal function.

Bibliography

Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G.-H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., & Akiyama, T. (1996). Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein. Science, 272(5264), 1020â1023.

Authors 11

Akihiko Matsumine (first)
Akiko Ogai (additional)
Takao Senda (additional)
Nobuaki Okumura (additional)
Kiyotoshi Satoh (additional)
Gyeong-Hun Baeg (additional)
Takeo Kawahara (additional)
Shigeru Kobayashi (additional)
Masato Okada (additional)
Kumao Toyoshima (additional)
Tetsu Akiyama (additional)

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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:45 p.m.)
Indexed	4 months ago (April 22, 2025, 3:13 a.m.)
Issued	29 years, 3 months ago (May 17, 1996)
Published	29 years, 3 months ago (May 17, 1996)
Published Print	29 years, 3 months ago (May 17, 1996)

Funders 0

None

BibTeX

@article{Matsumine_1996, title={Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5264.1020}, DOI={10.1126/science.272.5264.1020}, number={5264}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Matsumine, Akihiko and Ogai, Akiko and Senda, Takao and Okumura, Nobuaki and Satoh, Kiyotoshi and Baeg, Gyeong-Hun and Kawahara, Takeo and Kobayashi, Shigeru and Okada, Masato and Toyoshima, Kumao and Akiyama, Tetsu}, year={1996}, month=may, pages={1020–1023} }

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  "abstract": "<jats:p>\n            The adenomatous polyposis coli gene (\n            <jats:italic>APC</jats:italic>\n            ) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein \u03b2-catenin. Overexpression of APC blocks cell cycle progression. The APC-\u03b2-catenin complex was shown to bind to DLG, the human homolog of the\n            <jats:italic>Drosophila</jats:italic>\n            discs large tumor suppressor protein. This interaction required the carboxyl-terminal region of APC and the DLG homology repeat region of DLG. APC colocalized with DLG at the lateral cytoplasm in rat colon epithelial cells and at the synapse in cultured hippocampal neurons. These results suggest that the APC-DLG complex may participate in regulation of both cell cycle progression and neuronal function.\n          </jats:p>",
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