DOI: 10.1126/science.272.5264.1008. Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1

Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1

10.1126/science.272.5264.1008

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.

Bibliography

Kurten, R. C., Cadena, D. L., & Gill, G. N. (1996). Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1. Science, 272(5264), 1008â1010.

Authors 3

Richard C. Kurten (first)
Deborah L. Cadena (additional)
Gordon N. Gill (additional)

References 11 Referenced 316

ALTSCHUL S.F., BASIC LOCAL ALIGNMENT SEARCH TOOL, JOURNAL OF MOLECULAR BIOLOGY 215, 403 (1990). (10.1016/S0022-2836(05)80360-2) / JOURNAL OF MOLECULAR BIOLOGY / BASIC LOCAL ALIGNMENT SEARCH TOOL by ALTSCHUL S.F. (1990)
AUSUBEL F.M., CURRENT PROTOCOLS MO (1995). / CURRENT PROTOCOLS MO by AUSUBEL F.M. (1995)
CADENA D.L., THE INTRACELLULAR TYROSINE KINASE DOMAIN OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR UNDERGOES A CONFORMATIONAL CHANGE UPON AUTOPHOSPHORYLATION, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 260 (1994). (10.1016/S0021-9258(17)42343-X) / JOURNAL OF BIOLOGICAL CHEMISTRY / THE INTRACELLULAR TYROSINE KINASE DOMAIN OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR UNDERGOES A CONFORMATIONAL CHANGE UPON AUTOPHOSPHORYLATION by CADENA D.L. (1994)
EKENA K, THE SACCHAROMYCES-CEREVISIAE MVP1 GENE INTERACTS WITH VPS1 AND IS REQUIRED FOR VACUOLAR PROTEIN SORTING, MOLECULAR AND CELLULAR BIOLOGY 15, 1671 (1995). (10.1128/MCB.15.3.1671) / MOLECULAR AND CELLULAR BIOLOGY / THE SACCHAROMYCES-CEREVISIAE MVP1 GENE INTERACTS WITH VPS1 AND IS REQUIRED FOR VACUOLAR PROTEIN SORTING by EKENA K (1995)
FRENCH A.R., POSTENDOCYTIC TRAFFICKING OF EPIDERMAL GROWTH FACTOR-RECEPTOR COMPLEXES IS MEDIATED THROUGH SATURABLE AND SPECIFIC ENDOSOMAL INTERACTIONS, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 15749 (1994). (10.1016/S0021-9258(17)40744-7) / JOURNAL OF BIOLOGICAL CHEMISTRY / POSTENDOCYTIC TRAFFICKING OF EPIDERMAL GROWTH FACTOR-RECEPTOR COMPLEXES IS MEDIATED THROUGH SATURABLE AND SPECIFIC ENDOSOMAL INTERACTIONS by FRENCH A.R. (1994)
JOHNSON K.F., THE CYTOPLASMIC TAIL OF THE MANNOSE 6-PHOSPHATE INSULIN-LIKE GROWTH FACTOR-II RECEPTOR HAS 2 SIGNALS FOR LYSOSOMAL-ENZYME SORTING IN THE GOLGI, JOURNAL OF CELL BIOLOGY 119, 249 (1992). (10.1083/jcb.119.2.249) / JOURNAL OF CELL BIOLOGY / THE CYTOPLASMIC TAIL OF THE MANNOSE 6-PHOSPHATE INSULIN-LIKE GROWTH FACTOR-II RECEPTOR HAS 2 SIGNALS FOR LYSOSOMAL-ENZYME SORTING IN THE GOLGI by JOHNSON K.F. (1992)
KURTEN R.C. unpublished data.
LETOURNEUR F, A NOVEL DI-LEUCINE MOTIF AND A TYROSINE-BASED MOTIF INDEPENDENTLY MEDIATE LYSOSOMAL TARGETING AND ENDOCYTOSIS OF CD3 CHAINS, CELL 69, 1143 (1992). (10.1016/0092-8674(92)90636-Q) / CELL / A NOVEL DI-LEUCINE MOTIF AND A TYROSINE-BASED MOTIF INDEPENDENTLY MEDIATE LYSOSOMAL TARGETING AND ENDOCYTOSIS OF CD3 CHAINS by LETOURNEUR F (1992)
NESTEROV A, ASSOCIATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS WITH COATED PIT ADAPTINS VIA A TYROSINE PHOSPHORYLATION-REGULATED MECHANISM, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 6320 (1995). (10.1074/jbc.270.11.6320) / JOURNAL OF BIOLOGICAL CHEMISTRY / ASSOCIATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS WITH COATED PIT ADAPTINS VIA A TYROSINE PHOSPHORYLATION-REGULATED MECHANISM by NESTEROV A (1995)
OPRESKO L.K., ENDOCYTOSIS AND LYSOSOMAL TARGETING OF EPIDERMAL GROWTH-FACTOR RECEPTORS ARE MEDIATED BY DISTINCT SEQUENCES INDEPENDENT OF THE TYROSINE KINASE DOMAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 4325 (1995). (10.1074/jbc.270.9.4325) / JOURNAL OF BIOLOGICAL CHEMISTRY / ENDOCYTOSIS AND LYSOSOMAL TARGETING OF EPIDERMAL GROWTH-FACTOR RECEPTORS ARE MEDIATED BY DISTINCT SEQUENCES INDEPENDENT OF THE TYROSINE KINASE DOMAIN by OPRESKO L.K. (1995)
10.1016/0092-8674(93)90662-A

Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:46 p.m.)
Indexed	16 hours, 18 minutes ago (Aug. 29, 2025, 6:35 a.m.)
Issued	29 years, 3 months ago (May 17, 1996)
Published	29 years, 3 months ago (May 17, 1996)
Published Print	29 years, 3 months ago (May 17, 1996)

Funders 0

None

BibTeX

@article{Kurten_1996, title={Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5264.1008}, DOI={10.1126/science.272.5264.1008}, number={5264}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kurten, Richard C. and Cadena, Deborah L. and Gill, Gordon N.}, year={1996}, month=may, pages={1008–1010} }

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