HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
10.1126/science.272.5263.872
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated “fusin,” is a putative G protein-coupled receptor with seven transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD4-positive human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophage-tropic HIV-1 isolates.

Bibliography

Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996). HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor. Science, 272(5263), 872–877.

Authors 4
  1. Yu Feng (first)
  2. Christopher C. Broder (additional)
  3. Paul E. Kennedy (additional)
  4. Edward A. Berger (additional)
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Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 10:30 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:54 a.m.)
Indexed 1 day, 14 hours ago (Aug. 21, 2025, 1:55 p.m.)
Issued 29 years, 3 months ago (May 10, 1996)
Published 29 years, 3 months ago (May 10, 1996)
Published Print 29 years, 3 months ago (May 10, 1996)
Funders 0

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@article{Feng_1996, title={HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5263.872}, DOI={10.1126/science.272.5263.872}, number={5263}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Feng, Yu and Broder, Christopher C. and Kennedy, Paul E. and Berger, Edward A.}, year={1996}, month=may, pages={872–877} }