DOI: 10.1126/science.272.5261.560. Linkage of Replication to Start by the Cdk Inhibitor Sic1

Linkage of Replication to Start by the Cdk Inhibitor Sic1

10.1126/science.272.5261.560

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In Saccharomyces cerevisiae , three G 1 cyclins (Clns) are important for Start, the event committing cells to division. Sic1, an inhibitor of Clb-Cdc28 kinases, became phosphorylated at Start, and this phosphorylation depended on the activity of Clns. Sic1 was subsequently lost, which depended on the activity of Clns and the ubiquitin-conjugating enzyme Cdc34. Inactivation of Sic1 was the only nonredundant essential function of Clns, because a sic1 deletion rescued the inviability of the cln1 cln2 cln3 triple mutant. In sic1 mutants, DNA replication became uncoupled from budding. Thus, Sic1 may be a substrate of Cln-Cdc28 complexes, and phosphorylation and proteolysis of Sic1 may regulate commitment to replication at Start.

Bibliography

Schneider, B. L., Yang, Q.-H., & Futcher, A. B. (1996). Linkage of Replication to Start by the Cdk Inhibitor Sic1. Science, 272(5261), 560â562.

Authors 3

B. L. Schneider (first)
Q.-H. Yang (additional)
A. B. Futcher (additional)

References 21 Referenced 178

CROSS F UNPUB COMMUNICATION .
CROSS F.R. COMMUNICATION .
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DONOVAN J.D., P40(SDB25), A PUTATIVE CDK INHIBITOR, HAS A ROLE IN THE M/G(1) TRANSITION IN SACCHAROMYCES-CEREVISIAE, GENES & DEVELOPMENT 8, 1640 (1994). (10.1101/gad.8.14.1640) / GENES & DEVELOPMENT / P40(SDB25), A PUTATIVE CDK INHIBITOR, HAS A ROLE IN THE M/G(1) TRANSITION IN SACCHAROMYCES-CEREVISIAE by DONOVAN J.D. (1994)
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GARRELS J unpublished data.
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MENDENHALL M.D., DUAL REGULATION OF THE YEAST CDC28-P40 PROTEIN-KINASE COMPLEX - CELL-CYCLE, PHEROMONE, AND NUTRIENT LIMITATION EFFECTS, CELL 50, 927 (1987). (10.1016/0092-8674(87)90519-8) / CELL / DUAL REGULATION OF THE YEAST CDC28-P40 PROTEIN-KINASE COMPLEX - CELL-CYCLE, PHEROMONE, AND NUTRIENT LIMITATION EFFECTS by MENDENHALL M.D. (1987)
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SCHNEIDER B.L. unpublished data.
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TYERS M, COMPARISON OF THE SACCHAROMYCES-CEREVISIAE G1 CYCLINS - CLN3 MAY BE AN UPSTREAM ACTIVATOR OF CLN1, CLN2 AND OTHER CYCLINS, EMBO JOURNAL 12, 1955 (1993). (10.1002/j.1460-2075.1993.tb05845.x) / EMBO JOURNAL / COMPARISON OF THE SACCHAROMYCES-CEREVISIAE G1 CYCLINS - CLN3 MAY BE AN UPSTREAM ACTIVATOR OF CLN1, CLN2 AND OTHER CYCLINS by TYERS M (1993)
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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:57 p.m.)
Indexed	1 year ago (Aug. 7, 2024, 8:35 a.m.)
Issued	29 years, 3 months ago (April 26, 1996)
Published	29 years, 3 months ago (April 26, 1996)
Published Print	29 years, 3 months ago (April 26, 1996)

Funders 0

None

BibTeX

@article{Schneider_1996, title={Linkage of Replication to Start by the Cdk Inhibitor Sic1}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5261.560}, DOI={10.1126/science.272.5261.560}, number={5261}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schneider, B. L. and Yang, Q.-H. and Futcher, A. B.}, year={1996}, month=apr, pages={560–562} }

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