DOI: 10.1126/science.272.5260.408. A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

10.1126/science.272.5260.408

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.

Bibliography

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996). A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p. Science, 272(5260), 408â411.

Authors 3

Jack Taunton (first)
Christian A. Hassig (additional)
Stuart L. Schreiber (additional)

References 20 Referenced 1,473

APARICIO O.M., MODIFIERS OF POSITION EFFECT ARE SHARED BETWEEN TELOMERIC AND SILENT MATING-TYPE LOCI IN SACCHAROMYCES-CEREVISIAE, CELL 66, 1279 (1991). (10.1016/0092-8674(91)90049-5) / CELL / MODIFIERS OF POSITION EFFECT ARE SHARED BETWEEN TELOMERIC AND SILENT MATING-TYPE LOCI IN SACCHAROMYCES-CEREVISIAE by APARICIO O.M. (1991)
BOWDISH K.S., BIPARTITE STRUCTURE OF AN EARLY MEIOTIC UPSTREAM ACTIVATION SEQUENCE FROM SACCHAROMYCES-CEREVISIAE, MOLECULAR AND CELLULAR BIOLOGY 13, 2172 (1993). / MOLECULAR AND CELLULAR BIOLOGY / BIPARTITE STRUCTURE OF AN EARLY MEIOTIC UPSTREAM ACTIVATION SEQUENCE FROM SACCHAROMYCES-CEREVISIAE by BOWDISH K.S. (1993)
BRAUNSTEIN M, TRANSCRIPTIONAL SILENCING IN YEAST IS ASSOCIATED WITH REDUCED NUCLEOSOME ACETYLATION, GENES & DEVELOPMENT 7, 592 (1993). (10.1101/gad.7.4.592) / GENES & DEVELOPMENT / TRANSCRIPTIONAL SILENCING IN YEAST IS ASSOCIATED WITH REDUCED NUCLEOSOME ACETYLATION by BRAUNSTEIN M (1993)
CLIPSTONE N.A., IDENTIFICATION OF CALCINEURIN AS A KEY SIGNALING ENZYME IN LYMPHOCYTE-T ACTIVATION, NATURE 357, 695 (1992). (10.1038/357695a0) / NATURE / IDENTIFICATION OF CALCINEURIN AS A KEY SIGNALING ENZYME IN LYMPHOCYTE-T ACTIVATION by CLIPSTONE N.A. (1992)
HECHT A, HISTONE H3 AND H4 N-TERMINI INTERACT WITH SIR3 AND SIR4 PROTEINS - A MOLECULAR-MODEL FOR THE FORMATION OF HETEROCHROMATIN IN YEAST, CELL 80, 583 (1995). (10.1016/0092-8674(95)90512-X) / CELL / HISTONE H3 AND H4 N-TERMINI INTERACT WITH SIR3 AND SIR4 PROTEINS - A MOLECULAR-MODEL FOR THE FORMATION OF HETEROCHROMATIN IN YEAST by HECHT A (1995)
JOHNSON L.M., GENETIC-EVIDENCE FOR AN INTERACTION BETWEEN SIR3 AND HISTONE-H4 IN THE REPRESSION OF THE SILENT MATING LOCI IN SACCHAROMYCES-CEREVISIAE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87, 6286 (1990). (10.1073/pnas.87.16.6286) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / GENETIC-EVIDENCE FOR AN INTERACTION BETWEEN SIR3 AND HISTONE-H4 IN THE REPRESSION OF THE SILENT MATING LOCI IN SACCHAROMYCES-CEREVISIAE by JOHNSON L.M. (1990)
KIJIMA M, TRAPOXIN, AN ANTITUMOR CYCLIC TETRAPEPTIDE, IS AN IRREVERSIBLE INHIBITOR OF MAMMALIAN HISTONE DEACETYLASE, JOURNAL OF BIOLOGICAL CHEMISTRY 268, 22429 (1993). (10.1016/S0021-9258(18)41547-5) / JOURNAL OF BIOLOGICAL CHEMISTRY / TRAPOXIN, AN ANTITUMOR CYCLIC TETRAPEPTIDE, IS AN IRREVERSIBLE INHIBITOR OF MAMMALIAN HISTONE DEACETYLASE by KIJIMA M (1993)
KLEFF S, IDENTIFICATION OF A GENE ENCODING A YEAST HISTONE H4 ACETYLTRANSFERASE, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 24674 (1995). (10.1074/jbc.270.42.24674) / JOURNAL OF BIOLOGICAL CHEMISTRY / IDENTIFICATION OF A GENE ENCODING A YEAST HISTONE H4 ACETYLTRANSFERASE by KLEFF S (1995)
10.1016/0092-8674(93)90051-Q
MCKENZIE E.A., THE CENTROMERE AND PROMOTER FACTOR-I, CPF1, OF SACCHAROMYCES-CEREVISIAE MODULATES GENE ACTIVITY THROUGH A FAMILY OF FACTORS INCLUDING SPT21, RPD1 (SIN3), RPD3 AND CCR4, MOLECULAR & GENERAL GENETICS 240, 374 (1993). (10.1007/BF00280389) / MOLECULAR & GENERAL GENETICS / THE CENTROMERE AND PROMOTER FACTOR-I, CPF1, OF SACCHAROMYCES-CEREVISIAE MODULATES GENE ACTIVITY THROUGH A FAMILY OF FACTORS INCLUDING SPT21, RPD1 (SIN3), RPD3 AND CCR4 by MCKENZIE E.A. (1993)
10.1126/science.2106160
NASMYTH K, BOTH POSITIVE AND NEGATIVE REGULATORS OF HO TRANSCRIPTION ARE REQUIRED FOR MOTHER-CELL-SPECIFIC MATING-TYPE SWITCHING IN YEAST, CELL 48, 579 (1987). (10.1016/0092-8674(87)90236-4) / CELL / BOTH POSITIVE AND NEGATIVE REGULATORS OF HO TRANSCRIPTION ARE REQUIRED FOR MOTHER-CELL-SPECIFIC MATING-TYPE SWITCHING IN YEAST by NASMYTH K (1987)
10.1038/371297a0
PARK E.C., POINT MUTATIONS IN THE YEAST HISTONE-H4 GENE PREVENT SILENCING OF THE SILENT MATING TYPE LOCUS HML, MOLECULAR AND CELLULAR BIOLOGY 10, 4932 (1990). / MOLECULAR AND CELLULAR BIOLOGY / POINT MUTATIONS IN THE YEAST HISTONE-H4 GENE PREVENT SILENCING OF THE SILENT MATING TYPE LOCUS HML by PARK E.C. (1990)
QIAN Y.W., A RETINOBLASTOMA-BINDING PROTEIN RELATED TO A NEGATIVE REGULATOR OF RAS IN YEAST, NATURE 364, 648 (1993). (10.1038/364648a0) / NATURE / A RETINOBLASTOMA-BINDING PROTEIN RELATED TO A NEGATIVE REGULATOR OF RAS IN YEAST by QIAN Y.W. (1993)
STILLMAN D.J., EPISTASIS ANALYSIS OF SUPPRESSOR MUTATIONS THAT ALLOW HO EXPRESSION IN THE ABSENCE OF THE YEAST SW15 TRANSCRIPTIONAL ACTIVATOR, GENETICS 136, 781 (1994). (10.1093/genetics/136.3.781) / GENETICS / EPISTASIS ANALYSIS OF SUPPRESSOR MUTATIONS THAT ALLOW HO EXPRESSION IN THE ABSENCE OF THE YEAST SW15 TRANSCRIPTIONAL ACTIVATOR by STILLMAN D.J. (1994)
TAUNTON J unpublished data.
TURNER B.M., DECODING THE NUCLEOSOME, CELL 75, 5 (1993). (10.1016/S0092-8674(05)80078-9) / CELL / DECODING THE NUCLEOSOME by TURNER B.M. (1993)
VIDAL M, RPD3 ENCODES A 2ND FACTOR REQUIRED TO ACHIEVE MAXIMUM POSITIVE AND NEGATIVE TRANSCRIPTIONAL STATES IN SACCHAROMYCES-CEREVISIAE, MOLECULAR AND CELLULAR BIOLOGY 11, 6317 (1991). / MOLECULAR AND CELLULAR BIOLOGY / RPD3 ENCODES A 2ND FACTOR REQUIRED TO ACHIEVE MAXIMUM POSITIVE AND NEGATIVE TRANSCRIPTIONAL STATES IN SACCHAROMYCES-CEREVISIAE by VIDAL M (1991)
YOSHIDA M, TRICHOSTATIN-A AND TRAPOXIN - NOVEL CHEMICAL PROBES FOR THE ROLE OF HISTONE ACETYLATION IN CHROMATIN STRUCTURE AND FUNCTION, BIOESSAYS 17, 423 (1995). (10.1002/bies.950170510) / BIOESSAYS / TRICHOSTATIN-A AND TRAPOXIN - NOVEL CHEMICAL PROBES FOR THE ROLE OF HISTONE ACETYLATION IN CHROMATIN STRUCTURE AND FUNCTION by YOSHIDA M (1995)

Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:31 p.m.)
Indexed	3 days, 9 hours ago (Aug. 19, 2025, 6:33 a.m.)
Issued	29 years, 4 months ago (April 19, 1996)
Published	29 years, 4 months ago (April 19, 1996)
Published Print	29 years, 4 months ago (April 19, 1996)

Funders 0

None

BibTeX

@article{Taunton_1996, title={A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5260.408}, DOI={10.1126/science.272.5260.408}, number={5260}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Taunton, Jack and Hassig, Christian A. and Schreiber, Stuart L.}, year={1996}, month=apr, pages={408–411} }

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    "10.1126/science.272.5260.408"
  ],
  "URL": "http://dx.doi.org/10.1126/science.272.5260.408",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1996,
        4,
        19
      ]
    ]
  }
}