The Instructive Role of Innate Immunity in the Acquired Immune Response
10.1126/science.272.5258.50
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.

Bibliography

Fearon, D. T., & Locksley, R. M. (1996). The Instructive Role of Innate Immunity in the Acquired Immune Response. Science, 272(5258), 50–54.

Authors 2
  1. Douglas T. Fearon (first)
  2. Richard M. Locksley (additional)
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Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 5:01 p.m.)
Indexed 3 days, 10 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued 29 years, 4 months ago (April 5, 1996)
Published 29 years, 4 months ago (April 5, 1996)
Published Print 29 years, 4 months ago (April 5, 1996)
Funders 0

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@article{Fearon_1996, title={The Instructive Role of Innate Immunity in the Acquired Immune Response}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5258.50}, DOI={10.1126/science.272.5258.50}, number={5258}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Fearon, Douglas T. and Locksley, Richard M.}, year={1996}, month=apr, pages={50–54} }