DOI: 10.1126/science.272.5258.120. Role of the Nuclear Transport Factor p10 in Nuclear Import

Role of the Nuclear Transport Factor p10 in Nuclear Import

10.1126/science.272.5258.120

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The nuclear import factor p10 was cloned from Saccharomyces cerevisiae and found to be essential. The protein p10 can bind directly to several peptide repeat-containing nucleoporins. It also binds to the guanosine triphosphatase (GTPase) Ran in its guanosine diphosphate (GDP)-bound form and to karyopherin β. Assembly of the karyopherin heterodimer on immobilized nucleoporin yielded cooperative binding of p10 and Ran-GDP. Addition of GTP to this pentameric complex led to dissociation of karyopherin α, presumably via in situ formation of Ran-GTP from Ran-GDP. Thus, p10 appears to coordinate the Ran-dependent association and dissociation reactions underlying nuclear import.

Bibliography

Nehrbass, U., & Blobel, G. (1996). Role of the Nuclear Transport Factor p10 in Nuclear Import. Science, 272(5258), 120â122.

Authors 2

Ulf Nehrbass (first)
Günter Blobel (additional)

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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:02 p.m.)
Indexed	2 weeks, 5 days ago (Aug. 2, 2025, 12:39 a.m.)
Issued	29 years, 4 months ago (April 5, 1996)
Published	29 years, 4 months ago (April 5, 1996)
Published Print	29 years, 4 months ago (April 5, 1996)

Funders 0

None

BibTeX

@article{Nehrbass_1996, title={Role of the Nuclear Transport Factor p10 in Nuclear Import}, volume={272}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.272.5258.120}, DOI={10.1126/science.272.5258.120}, number={5258}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Nehrbass, Ulf and Blobel, Günter}, year={1996}, month=apr, pages={120–122} }

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