DOI: 10.1126/science.271.5257.1873. An RNA Polymerase II Elongation Factor Encoded by the Human <i>ELL</i> Gene

An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene

10.1126/science.271.5257.1873

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The human ELL gene on chromosome 19 undergoes frequent translocations with the trithorax -like MLL gene on chromosome 11 in acute myeloid leukemias. Here, ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau ( VHL ) tumor suppressor gene. The discovery of a second elongation factor implicated in oncogenesis provides further support for a close connection between the regulation of transcription elongation and cell growth.

Bibliography

Shilatifard, A., Lane, W. S., Jackson, K. W., Conaway, R. C., & Conaway, J. W. (1996). An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene. Science, 271(5257), 1873â1876.

Authors 5

Ali Shilatifard (first)
William S. Lane (additional)
Kenneth W. Jackson (additional)
Ronald C. Conaway (additional)
Joan W. Conaway (additional)

References 25 Referenced 282

ASO T, THE RNA-POLYMERASE-II ELONGATION COMPLEX, FASEB JOURNAL 9, 1419 (1995). (10.1096/fasebj.9.14.7589983) / FASEB JOURNAL / THE RNA-POLYMERASE-II ELONGATION COMPLEX by ASO T (1995)
10.1126/science.7660129
BERNARD A. O., A NOVEL GENE, AF-1P, FUSED TO HRX IN T(1,11)(P32,Q23), IS NOT RELATED TO AF-4, AF-9 NOR ENL, ONCOGENE 9, 1039 (1994). / ONCOGENE / A NOVEL GENE, AF-1P, FUSED TO HRX IN T(1,11)(P32,Q23), IS NOT RELATED TO AF-4, AF-9 NOR ENL by BERNARD A. O. (1994)
CLEARY L. M., ONCOGENIC CONVERSION OF TRANSCRIPTION FACTORS BY CHROMOSOMAL TRANSLOCATIONS, CELL 66, 619 (1991). (10.1016/0092-8674(91)90105-8) / CELL / ONCOGENIC CONVERSION OF TRANSCRIPTION FACTORS BY CHROMOSOMAL TRANSLOCATIONS by CLEARY L. M. (1991)
CONAWAY C. R., AN RNA POLYMERASE-II TRANSCRIPTION FACTOR HAS AN ASSOCIATED DNA-DEPENDENT ATPASE (DATPASE) ACTIVITY STRONGLY STIMULATED BY THE TATA REGION OF PROMOTERS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86, 7356 (1989). (10.1073/pnas.86.19.7356) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / AN RNA POLYMERASE-II TRANSCRIPTION FACTOR HAS AN ASSOCIATED DNA-DEPENDENT ATPASE (DATPASE) ACTIVITY STRONGLY STIMULATED BY THE TATA REGION OF PROMOTERS by CONAWAY C. R. (1989)
CORRAL J, ACUTE LEUKEMIAS OF DIFFERENT LINEAGES HAVE SIMILAR MLL GENE FUSIONS ENCODING RELATED CHIMERIC PROTEINS RESULTING FROM CHROMOSOMAL TRANSLOCATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90, 8538 (1993). (10.1073/pnas.90.18.8538) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / ACUTE LEUKEMIAS OF DIFFERENT LINEAGES HAVE SIMILAR MLL GENE FUSIONS ENCODING RELATED CHIMERIC PROTEINS RESULTING FROM CHROMOSOMAL TRANSLOCATION by CORRAL J (1993)
DOMER H. P., ACUTE MIXED-LINEAGE LEUKEMIA T(4-11)(Q21-Q23) GENERATES AN MLL-AF4 FUSION PRODUCT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90, 7884 (1993). (10.1073/pnas.90.16.7884) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / ACUTE MIXED-LINEAGE LEUKEMIA T(4-11)(Q21-Q23) GENERATES AN MLL-AF4 FUSION PRODUCT by DOMER H. P. (1993)
10.1126/science.7660122
GARRETT P. K., MOLECULAR-CLONING OF AN ESSENTIAL SUBUNIT OF RNA-POLYMERASE-II ELONGATION-FACTOR SIII, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 5237 (1994). (10.1073/pnas.91.12.5237) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / MOLECULAR-CLONING OF AN ESSENTIAL SUBUNIT OF RNA-POLYMERASE-II ELONGATION-FACTOR SIII by GARRETT P. K. (1994)
GARRETT P. K., POSITIVE REGULATION OF GENERAL TRANSCRIPTION FACTOR SIII BY A TAILED UBIQUITIN HOMOLOG, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 7172 (1995). (10.1073/pnas.92.16.7172) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / POSITIVE REGULATION OF GENERAL TRANSCRIPTION FACTOR SIII BY A TAILED UBIQUITIN HOMOLOG by GARRETT P. K. (1995)
GU Y, THE T(4-11) CHROMOSOME-TRANSLOCATION OF HUMAN ACUTE LEUKEMIAS FUSES THE ALL-1 GENE, RELATED TO DROSOPHILA-TRITHORAX, TO THE AF-4 GENE, CELL 71, 701 (1992). (10.1016/0092-8674(92)90603-A) / CELL / THE T(4-11) CHROMOSOME-TRANSLOCATION OF HUMAN ACUTE LEUKEMIAS FUSES THE ALL-1 GENE, RELATED TO DROSOPHILA-TRITHORAX, TO THE AF-4 GENE by GU Y (1992)
10.1126/science.7660130
10.1007/BF01024778
MARSHALL F. N., PURIFICATION OF P-TEFB, A TRANSCRIPTION FACTOR REQUIRED FOR THE TRANSITION INTO PRODUCTIVE ELONGATION, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 12335 (1995). (10.1074/jbc.270.21.12335) / JOURNAL OF BIOLOGICAL CHEMISTRY / PURIFICATION OF P-TEFB, A TRANSCRIPTION FACTOR REQUIRED FOR THE TRANSITION INTO PRODUCTIVE ELONGATION by MARSHALL F. N. (1995)
MITANI K, CLONING OF SEVERAL SPECIES OF MLL/MEN CHIMERIC CDNAS IN MYELOID-LEUKEMIA WITH T(11-19)(Q23-P13.1) TRANSLOCATION, BLOOD 85, 2017 (1995). (10.1182/blood.V85.8.2017.bloodjournal8582017) / BLOOD / CLONING OF SEVERAL SPECIES OF MLL/MEN CHIMERIC CDNAS IN MYELOID-LEUKEMIA WITH T(11-19)(Q23-P13.1) TRANSLOCATION by MITANI K (1995)
NAKAMURA T, GENES ON CHROMOSOME-4, CHROMOSOME-9, AND CHROMOSOME-19 INVOLVED IN 11Q23 ABNORMALITIES IN ACUTE-LEUKEMIA SHARE SEQUENCE HOMOLOGY AND OR COMMON MOTIFS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90, 4631 (1993). (10.1073/pnas.90.10.4631) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / GENES ON CHROMOSOME-4, CHROMOSOME-9, AND CHROMOSOME-19 INVOLVED IN 11Q23 ABNORMALITIES IN ACUTE-LEUKEMIA SHARE SEQUENCE HOMOLOGY AND OR COMMON MOTIFS by NAKAMURA T (1993)
PRASAD R, CLONING OF THE ALL-1 FUSION PARTNER, THE AF-6 GENE, INVOLVED IN ACUTE MYELOID LEUKEMIAS WITH THE T(6 11) CHROMOSOME-TRANSLOCATION, CANCER RESEARCH 53, 5624 (1993). / CANCER RESEARCH / CLONING OF THE ALL-1 FUSION PARTNER, THE AF-6 GENE, INVOLVED IN ACUTE MYELOID LEUKEMIAS WITH THE T(6 11) CHROMOSOME-TRANSLOCATION by PRASAD R (1993)
RABBITTS H. T., CHROMOSOMAL TRANSLOCATIONS IN HUMAN CANCER, NATURE 372, 143 (1994). (10.1038/372143a0) / NATURE / CHROMOSOMAL TRANSLOCATIONS IN HUMAN CANCER by RABBITTS H. T. (1994)
RICE A. G., FOOTPRINTING ANALYSIS OF MAMMALIAN RNA POLYMERASE-II ALONG ITS TRANSCRIPT - AN ALTERNATIVE VIEW OF TRANSCRIPTION ELONGATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88, 4245 (1991). (10.1073/pnas.88.10.4245) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / FOOTPRINTING ANALYSIS OF MAMMALIAN RNA POLYMERASE-II ALONG ITS TRANSCRIPT - AN ALTERNATIVE VIEW OF TRANSCRIPTION ELONGATION by RICE A. G. (1991)
SERIZAWA H, A CARBOXYL-TERMINAL-DOMAIN KINASE ASSOCIATED WITH RNA POLYMERASE-II TRANSCRIPTION FACTOR-DELTA FROM RAT-LIVER, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89, 7476 (1992). (10.1073/pnas.89.16.7476) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / A CARBOXYL-TERMINAL-DOMAIN KINASE ASSOCIATED WITH RNA POLYMERASE-II TRANSCRIPTION FACTOR-DELTA FROM RAT-LIVER by SERIZAWA H (1992)
SHILATIFARD A unpublished data.
10.1126/science.1957167
TAN S, A BACTERIOPHAGE VECTOR SUITABLE FOR SITE-DIRECTED MUTAGENESIS AND HIGH-LEVEL EXPRESSION OF MULTISUBUNIT PROTEINS IN ESCHERICHIA-COLI, BIOTECHNIQUES 16, 824 (1994). / BIOTECHNIQUES / A BACTERIOPHAGE VECTOR SUITABLE FOR SITE-DIRECTED MUTAGENESIS AND HIGH-LEVEL EXPRESSION OF MULTISUBUNIT PROTEINS IN ESCHERICHIA-COLI by TAN S (1994)
THIRMAN J. M., CLONING OF ELL, A GENE THAT FUSES TO MLL IN A T(11-19)(Q23-P13.1) IN ACUTE MYELOID-LEUKEMIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 12110 (1994). (10.1073/pnas.91.25.12110) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / CLONING OF ELL, A GENE THAT FUSES TO MLL IN A T(11-19)(Q23-P13.1) IN ACUTE MYELOID-LEUKEMIA by THIRMAN J. M. (1994)
TKACHUK C. D., INVOLVEMENT OF A HOMOLOG OF DROSOPHILA-TRITHORAX BY 11Q23 CHROMOSOMAL TRANSLOCATIONS IN ACUTE LEUKEMIAS, CELL 71, 691 (1992). (10.1016/0092-8674(92)90602-9) / CELL / INVOLVEMENT OF A HOMOLOG OF DROSOPHILA-TRITHORAX BY 11Q23 CHROMOSOMAL TRANSLOCATIONS IN ACUTE LEUKEMIAS by TKACHUK C. D. (1992)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:26 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 9:56 a.m.)
Issued	29 years, 5 months ago (March 29, 1996)
Published	29 years, 5 months ago (March 29, 1996)
Published Print	29 years, 5 months ago (March 29, 1996)

Funders 0

None

BibTeX

@article{Shilatifard_1996, title={An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5257.1873}, DOI={10.1126/science.271.5257.1873}, number={5257}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Shilatifard, Ali and Lane, William S. and Jackson, Kenneth W. and Conaway, Ronald C. and Conaway, Joan W.}, year={1996}, month=mar, pages={1873–1876} }

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      "author": "CONAWAY C. R.",
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