DOI: 10.1126/science.271.5257.1826. Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled

10.1126/science.271.5257.1826

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In Drosophila , the Wingless and Notch signaling pathways function in many of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Wingless signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

Bibliography

Axelrod, J. D., Matsuno, K., Artavanis-Tsakonas, S., & Perrimon, N. (1996). Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled. Science, 271(5257), 1826â1832.

Authors 4

Jeffrey D. Axelrod (first)
Kenji Matsuno (additional)
Spyros Artavanis-Tsakonas (additional)
Norbert Perrimon (additional)

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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:25 p.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 2:28 a.m.)
Issued	29 years, 4 months ago (March 29, 1996)
Published	29 years, 4 months ago (March 29, 1996)
Published Print	29 years, 4 months ago (March 29, 1996)

Funders 0

None

BibTeX

@article{Axelrod_1996, title={Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5257.1826}, DOI={10.1126/science.271.5257.1826}, number={5257}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Axelrod, Jeffrey D. and Matsuno, Kenji and Artavanis-Tsakonas, Spyros and Perrimon, Norbert}, year={1996}, month=mar, pages={1826–1832} }

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