Abnormal Centrosome Amplification in the Absence of p53
10.1126/science.271.5256.1744
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The centrosome plays a vital role in mitotic fidelity, ensuring establishment of bipolar spindles and balanced chromosome segregation. Centrosome duplication occurs only once during the cell cycle and is therefore highly regulated. Here, it is shown that in mouse embryonic fibroblasts (MEFs) lacking the p53 tumor suppressor protein, multiple copies of functionally competent centrosomes are generated during a single cell cycle. In contrast, MEFs prepared from normal mice or mice deficient in the retinoblastoma tumor suppressor gene product do not display these abnormalities. The abnormally amplified centrosomes profoundly affect mitotic fidelity, resulting in unequal segregation of chromosomes. These observations implicate p53 in the regulation of centrosome duplication and suggest one possible mechanism by which the loss of p53 may cause genetic instability.

Bibliography

Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S., & Woude, G. F. V. (1996). Abnormal Centrosome Amplification in the Absence of p53. Science, 271(5256), 1744–1747.

Authors 5
  1. Kenji Fukasawa (first)
  2. Taesaeng Choi (additional)
  3. Ryoko Kuriyama (additional)
  4. Shen Rulong (additional)
  5. George F. Vande Woude (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 27, 2006, 10:30 a.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:12 a.m.)
Indexed 4 days, 6 hours ago (Aug. 28, 2025, 8:54 a.m.)
Issued 29 years, 5 months ago (March 22, 1996)
Published 29 years, 5 months ago (March 22, 1996)
Published Print 29 years, 5 months ago (March 22, 1996)
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@article{Fukasawa_1996, title={Abnormal Centrosome Amplification in the Absence of p53}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5256.1744}, DOI={10.1126/science.271.5256.1744}, number={5256}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Fukasawa, Kenji and Choi, Taesaeng and Kuriyama, Ryoko and Rulong, Shen and Woude, George F. Vande}, year={1996}, month=mar, pages={1744–1747} }