Nucleocytoplasmic Transport
10.1126/science.271.5255.1513
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation requires energy, and for the import process this energy is at least partly consumed by the action of the small guanosine triphosphatase Ran. In the first half of the review, some of the well-established general background information on nucleocytoplasmic transport is discussed. The second half describes recent information on the mechanistic details of nuclear import and export as well as major unresolved issues such as how directionality is conferred on either import or export. The whole review is slanted toward discussion of metazoan cells.

Bibliography

Görlich, D., & Mattaj, I. W. (1996). Nucleocytoplasmic Transport. Science, 271(5255), 1513–1519.

Authors 2
  1. Dirk Görlich (first)
  2. Iain W. Mattaj (additional)
References 94 Referenced 957
  1. ADAM EJH, IDENTIFICATION OF CYTOSOLIC FACTORS REQUIRED FOR NUCLEAR LOCATION SEQUENCE-MEDIATED BINDING TO THE NUCLEAR-ENVELOPE, JOURNAL OF CELL BIOLOGY 125, 547 (1994). (10.1083/jcb.125.3.547) / JOURNAL OF CELL BIOLOGY / IDENTIFICATION OF CYTOSOLIC FACTORS REQUIRED FOR NUCLEAR LOCATION SEQUENCE-MEDIATED BINDING TO THE NUCLEAR-ENVELOPE by ADAM EJH (1994)
  2. ADAM A. S., CYTOSOLIC PROTEINS THAT SPECIFICALLY BIND NUCLEAR LOCATION SIGNALS ARE RECEPTORS FOR NUCLEAR IMPORT, CELL 66, 837 (1991). (10.1016/0092-8674(91)90431-W) / CELL / CYTOSOLIC PROTEINS THAT SPECIFICALLY BIND NUCLEAR LOCATION SIGNALS ARE RECEPTORS FOR NUCLEAR IMPORT by ADAM A. S. (1991)
  3. ADAM A. S., NUCLEAR-PROTEIN IMPORT IN PERMEABILIZED MAMMALIAN-CELLS REQUIRES SOLUBLE CYTOPLASMIC FACTORS, JOURNAL OF CELL BIOLOGY 111, 807 (1990). (10.1083/jcb.111.3.807) / JOURNAL OF CELL BIOLOGY / NUCLEAR-PROTEIN IMPORT IN PERMEABILIZED MAMMALIAN-CELLS REQUIRES SOLUBLE CYTOPLASMIC FACTORS by ADAM A. S. (1990)
  4. BISCHOFF R. F., COACTIVATION OF RANGTPASE AND INHIBITION OF GTP DISSOCIATION BY RAN GTP-BINDING PROTEIN RANBP1, EMBO JOURNAL 14, 705 (1995). (10.1002/j.1460-2075.1995.tb07049.x) / EMBO JOURNAL / COACTIVATION OF RANGTPASE AND INHIBITION OF GTP DISSOCIATION BY RAN GTP-BINDING PROTEIN RANBP1 by BISCHOFF R. F. (1995)
  5. BISCHOFF R. F., CATALYSIS OF GUANINE-NUCLEOTIDE EXCHANGE ON RAN BY THE MITOTIC REGULATOR RCC1, NATURE 354, 80 (1991). (10.1038/354080a0) / NATURE / CATALYSIS OF GUANINE-NUCLEOTIDE EXCHANGE ON RAN BY THE MITOTIC REGULATOR RCC1 by BISCHOFF R. F. (1991)
  6. BISCHOFF R. F., MITOTIC REGULATOR PROTEIN RCC1 IS COMPLEXED WITH A NUCLEAR RAS-RELATED POLYPEPTIDE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88, 10830 (1991). (10.1073/pnas.88.23.10830) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / MITOTIC REGULATOR PROTEIN RCC1 IS COMPLEXED WITH A NUCLEAR RAS-RELATED POLYPEPTIDE by BISCHOFF R. F. (1991)
  7. BISCHOFF R. F., HUMAN RANGTPASE-ACTIVATING PROTEIN RANGAP1 IS A HOMOLOG OF YEAST RNA1P INVOLVED IN MESSENGER-RNA PROCESSING AND TRANSPORT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 1749 (1995). (10.1073/pnas.92.5.1749) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / HUMAN RANGTPASE-ACTIVATING PROTEIN RANGAP1 IS A HOMOLOG OF YEAST RNA1P INVOLVED IN MESSENGER-RNA PROCESSING AND TRANSPORT by BISCHOFF R. F. (1995)
  8. BOGERD P. H., IDENTIFICATION OF A NOVEL CELLULAR COFACTOR FOR THE REV/REX CLASS OF RETROVIRAL REGULATORY PROTEINS, CELL 82, 485 (1995). (10.1016/0092-8674(95)90437-9) / CELL / IDENTIFICATION OF A NOVEL CELLULAR COFACTOR FOR THE REV/REX CLASS OF RETROVIRAL REGULATORY PROTEINS by BOGERD P. H. (1995)
  9. BONNER M. W., CELL NUCLEUS 6, 97 (1978). / CELL NUCLEUS by BONNER M. W. (1978)
  10. BORK P, NAT GENET 11, 115 (1995). (10.1038/ng1095-115) / NAT GENET by BORK P (1995)
  11. BREEUWER M, FACILITATED NUCLEAR TRANSPORT OF HISTONE H1 AND OTHER SMALL NUCLEOPHILIC PROTEINS, CELL 60, 999 (1990). (10.1016/0092-8674(90)90348-I) / CELL / FACILITATED NUCLEAR TRANSPORT OF HISTONE H1 AND OTHER SMALL NUCLEOPHILIC PROTEINS by BREEUWER M (1990)
  12. CHI C. N., SEQUENCE AND CHARACTERIZATION OF CYTOPLASMIC NUCLEAR-PROTEIN IMPORT FACTOR P97, JOURNAL OF CELL BIOLOGY 130, 265 (1995). (10.1083/jcb.130.2.265) / JOURNAL OF CELL BIOLOGY / SEQUENCE AND CHARACTERIZATION OF CYTOPLASMIC NUCLEAR-PROTEIN IMPORT FACTOR P97 by CHI C. N. (1995)
  13. CORTES P, RAG-1 INTERACTS WITH THE REPEATED AMINO-ACID MOTIF OF THE HUMAN HOMOLOG OF THE YEAST PROTEIN SRP1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 7633 (1994). (10.1073/pnas.91.16.7633) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / RAG-1 INTERACTS WITH THE REPEATED AMINO-ACID MOTIF OF THE HUMAN HOMOLOG OF THE YEAST PROTEIN SRP1 by CORTES P (1994)
  14. CULLEN R. B., THE HIV-1 REV PROTEIN - PROTOTYPE OF A NOVEL CLASS OF EUKARYOTIC POSTTRANSCRIPTIONAL REGULATORS, TRENDS IN BIOCHEMICAL SCIENCES 16, 346 (1991). (10.1016/0968-0004(91)90141-H) / TRENDS IN BIOCHEMICAL SCIENCES / THE HIV-1 REV PROTEIN - PROTOTYPE OF A NOVEL CLASS OF EUKARYOTIC POSTTRANSCRIPTIONAL REGULATORS by CULLEN R. B. (1991)
  15. CUOMO A. C., RCH1, A PROTEIN THAT SPECIFICALLY INTERACTS WITH THE RAG-1 RECOMBINATION-ACTIVATING PROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 6156 (1994). (10.1073/pnas.91.13.6156) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / RCH1, A PROTEIN THAT SPECIFICALLY INTERACTS WITH THE RAG-1 RECOMBINATION-ACTIVATING PROTEIN by CUOMO A. C. (1994)
  16. DAVIS I. L., THE NUCLEAR-PORE COMPLEX, ANNUAL REVIEW OF BIOCHEMISTRY 64, 865 (1995). (10.1146/annurev.bi.64.070195.004245) / ANNUAL REVIEW OF BIOCHEMISTRY / THE NUCLEAR-PORE COMPLEX by DAVIS I. L. (1995)
  17. DINGWALL C, A POLYPEPTIDE DOMAIN THAT SPECIFIES MIGRATION OF NUCLEOPLASMIN INTO THE NUCLEUS, CELL 30, 449 (1982). (10.1016/0092-8674(82)90242-2) / CELL / A POLYPEPTIDE DOMAIN THAT SPECIFIES MIGRATION OF NUCLEOPLASMIN INTO THE NUCLEUS by DINGWALL C (1982)
  18. DINGWALL C, A FAMILY OF RAN BINDING-PROTEINS THAT INCLUDES NUCLEOPORINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 7525 (1995). (10.1073/pnas.92.16.7525) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / A FAMILY OF RAN BINDING-PROTEINS THAT INCLUDES NUCLEOPORINS by DINGWALL C (1995)
  19. DINGWALL C, NUCLEAR TARGETING SEQUENCES - A CONSENSUS, TRENDS IN BIOCHEMICAL SCIENCES 16, 478 (1991). (10.1016/0968-0004(91)90184-W) / TRENDS IN BIOCHEMICAL SCIENCES / NUCLEAR TARGETING SEQUENCES - A CONSENSUS by DINGWALL C (1991)
  20. DRIVAS T. G., CHARACTERIZATION OF 4 NOVEL RAS-LIKE GENES EXPRESSED IN A HUMAN TERATOCARCINOMA CELL-LINE, MOLECULAR AND CELLULAR BIOLOGY 10, 1793 (1990). / MOLECULAR AND CELLULAR BIOLOGY / CHARACTERIZATION OF 4 NOVEL RAS-LIKE GENES EXPRESSED IN A HUMAN TERATOCARCINOMA CELL-LINE by DRIVAS T. G. (1990)
  21. FABRE E, NUCLEAR TRANSPORT, CURRENT OPINION IN CELL BIOLOGY 6, 335 (1994). (10.1016/0955-0674(94)90023-X) / CURRENT OPINION IN CELL BIOLOGY / NUCLEAR TRANSPORT by FABRE E (1994)
  22. FELDHERR M. C., REGULATION OF NUCLEAR TRANSPORT IN PROLIFERATING AND QUIESCENT CELLS, EXPERIMENTAL CELL RESEARCH 205, 179 (1993). (10.1006/excr.1993.1073) / EXPERIMENTAL CELL RESEARCH / REGULATION OF NUCLEAR TRANSPORT IN PROLIFERATING AND QUIESCENT CELLS by FELDHERR M. C. (1993)
  23. FELDHERR M. C., NUCLEAR ANNULI AS PATHWAYS FOR NUCLEOCYTOPLASMIC EXCHANGES, JOURNAL OF CELL BIOLOGY 14, 65 (1962). (10.1083/jcb.14.1.65) / JOURNAL OF CELL BIOLOGY / NUCLEAR ANNULI AS PATHWAYS FOR NUCLEOCYTOPLASMIC EXCHANGES by FELDHERR M. C. (1962)
  24. FELDHERR M. C., MOVEMENT OF A CARYOPHILIC PROTEIN THROUGH THE NUCLEAR-PORES OF OOCYTES, JOURNAL OF CELL BIOLOGY 99, 2216 (1984). (10.1083/jcb.99.6.2216) / JOURNAL OF CELL BIOLOGY / MOVEMENT OF A CARYOPHILIC PROTEIN THROUGH THE NUCLEAR-PORES OF OOCYTES by FELDHERR M. C. (1984)
  25. FINER T. J., SINGLE MYOSIN MOLECULE MECHANICS - PICONEWTON FORCES AND NANOMETER STEPS, NATURE 368, 113 (1994). (10.1038/368113a0) / NATURE / SINGLE MYOSIN MOLECULE MECHANICS - PICONEWTON FORCES AND NANOMETER STEPS by FINER T. J. (1994)
  26. 10.1016/0092-8674(95)90436-0
  27. FISCHER U, DIVERSITY IN THE SIGNALS REQUIRED FOR NUCLEAR ACCUMULATION OF U SNRNPS AND VARIETY IN THE PATHWAYS OF NUCLEAR TRANSPORT, JOURNAL OF CELL BIOLOGY 113, 705 (1991). (10.1083/jcb.113.4.705) / JOURNAL OF CELL BIOLOGY / DIVERSITY IN THE SIGNALS REQUIRED FOR NUCLEAR ACCUMULATION OF U SNRNPS AND VARIETY IN THE PATHWAYS OF NUCLEAR TRANSPORT by FISCHER U (1991)
  28. FRIDELL A. R., IN PRESS P NATL ACAD . / IN PRESS P NATL ACAD by FRIDELL A. R.
  29. FRITZ C. C., A HUMAN NUCLEOPORIN-LIKE PROTEIN THAT SPECIFICALLY INTERACTS WITH HIV REV, NATURE 376, 530 (1995). (10.1038/376530a0) / NATURE / A HUMAN NUCLEOPORIN-LIKE PROTEIN THAT SPECIFICALLY INTERACTS WITH HIV REV by FRITZ C. C. (1995)
  30. GERACE L, NUCLEAR EXPORT SIGNALS AND THE FAST-TRACK TO THE CYTOPLASM, CELL 82, 341 (1995). (10.1016/0092-8674(95)90420-4) / CELL / NUCLEAR EXPORT SIGNALS AND THE FAST-TRACK TO THE CYTOPLASM by GERACE L (1995)
  31. GOLDFARB S. D., SYNTHETIC PEPTIDES AS NUCLEAR-LOCALIZATION SIGNALS, NATURE 322, 641 (1986). (10.1038/322641a0) / NATURE / SYNTHETIC PEPTIDES AS NUCLEAR-LOCALIZATION SIGNALS by GOLDFARB S. D. (1986)
  32. GORLICH D, ISOLATION OF A PROTEIN THAT IS ESSENTIAL FOR THE FIRST STEP OF NUCLEAR-PROTEIN IMPORT, CELL 79, 767 (1994). (10.1016/0092-8674(94)90067-1) / CELL / ISOLATION OF A PROTEIN THAT IS ESSENTIAL FOR THE FIRST STEP OF NUCLEAR-PROTEIN IMPORT by GORLICH D (1994)
  33. GORLICH D, 2 DIFFERENT SUBUNITS OF IMPORTIN COOPERATE TO RECOGNIZE NUCLEAR-LOCALIZATION SIGNALS AND BIND THEM TO THE NUCLEAR-ENVELOPE, CURRENT BIOLOGY 5, 383 (1995). (10.1016/S0960-9822(95)00079-0) / CURRENT BIOLOGY / 2 DIFFERENT SUBUNITS OF IMPORTIN COOPERATE TO RECOGNIZE NUCLEAR-LOCALIZATION SIGNALS AND BIND THEM TO THE NUCLEAR-ENVELOPE by GORLICH D (1995)
  34. GORLICH D, IN PRESS EMBO J . / IN PRESS EMBO J by GORLICH D
  35. GORLICH D, DISTINCT FUNCTIONS FOR THE 2 IMPORTIN SUBUNITS IN NUCLEAR-PROTEIN IMPORT, NATURE 377, 246 (1995). (10.1038/377246a0) / NATURE / DISTINCT FUNCTIONS FOR THE 2 IMPORTIN SUBUNITS IN NUCLEAR-PROTEIN IMPORT by GORLICH D (1995)
  36. GORLICH D unpublished data.
  37. GORSCH C. L., A CONDITIONAL ALLELE OF THE NOVEL REPEAT-CONTAINING YEAST NUCLEOPORIN RAT7 NUP159 CAUSES BOTH RAPID CESSATION OF MESSENGER-RNA EXPORT AND REVERSIBLE CLUSTERING OF NUCLEAR-PORE COMPLEXES, JOURNAL OF CELL BIOLOGY 129, 939 (1995). (10.1083/jcb.129.4.939) / JOURNAL OF CELL BIOLOGY / A CONDITIONAL ALLELE OF THE NOVEL REPEAT-CONTAINING YEAST NUCLEOPORIN RAT7 NUP159 CAUSES BOTH RAPID CESSATION OF MESSENGER-RNA EXPORT AND REVERSIBLE CLUSTERING OF NUCLEAR-PORE COMPLEXES by GORSCH C. L. (1995)
  38. GUDDAT U, PROTEIN-MEDIATED NUCLEAR EXPORT OF RNA - 5S RIBOSOMAL-RNA CONTAINING SMALL RNPS IN XENOPUS OOCYTES, CELL 60, 619 (1990). (10.1016/0092-8674(90)90665-2) / CELL / PROTEIN-MEDIATED NUCLEAR EXPORT OF RNA - 5S RIBOSOMAL-RNA CONTAINING SMALL RNPS IN XENOPUS OOCYTES by GUDDAT U (1990)
  39. IMAMOTO N, IN-VIVO EVIDENCE FOR INVOLVEMENT OF A 58 KDA COMPONENT OF NUCLEAR PORE-TARGETING COMPLEX IN NUCLEAR-PROTEIN IMPORT, EMBO JOURNAL 14, 3617 (1995). (10.1002/j.1460-2075.1995.tb00031.x) / EMBO JOURNAL / IN-VIVO EVIDENCE FOR INVOLVEMENT OF A 58 KDA COMPONENT OF NUCLEAR PORE-TARGETING COMPLEX IN NUCLEAR-PROTEIN IMPORT by IMAMOTO N (1995)
  40. IMAMOTO N, THE NUCLEAR PORE-TARGETING COMPLEX BINDS TO NUCLEAR-PORES AFTER ASSOCIATION WITH A KARYOPHILE, FEBS LETTERS 368, 415 (1995). (10.1016/0014-5793(95)00699-A) / FEBS LETTERS / THE NUCLEAR PORE-TARGETING COMPLEX BINDS TO NUCLEAR-PORES AFTER ASSOCIATION WITH A KARYOPHILE by IMAMOTO N (1995)
  41. IMAMOTO N, A KARYOPHILIC PROTEIN FORMS A STABLE COMPLEX WITH CYTOPLASMIC COMPONENTS PRIOR TO NUCLEAR-PORE BINDING, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 8559 (1995). (10.1074/jbc.270.15.8559) / JOURNAL OF BIOLOGICAL CHEMISTRY / A KARYOPHILIC PROTEIN FORMS A STABLE COMPLEX WITH CYTOPLASMIC COMPONENTS PRIOR TO NUCLEAR-PORE BINDING by IMAMOTO N (1995)
  42. IOVINE K. M., J CELL BIOL 1319, 95. / J CELL BIOL by IOVINE K. M.
  43. IZAURRALDE E, A NUCLEAR CAP-BINDING PROTEIN COMPLEX INVOLVED IN PRE-MESSENGER-RNA SPLICING, CELL 78, 657 (1994). (10.1016/0092-8674(94)90530-4) / CELL / A NUCLEAR CAP-BINDING PROTEIN COMPLEX INVOLVED IN PRE-MESSENGER-RNA SPLICING by IZAURRALDE E (1994)
  44. IZAURRALDE E, RNA EXPORT, CELL 81, 153 (1995). (10.1016/0092-8674(95)90323-2) / CELL / RNA EXPORT by IZAURRALDE E (1995)
  45. IZAURRALDE E, A CAP-BINDING PROTEIN COMPLEX MEDIATING U SNRNA EXPORT, NATURE 376, 709 (1995). (10.1038/376709a0) / NATURE / A CAP-BINDING PROTEIN COMPLEX MEDIATING U SNRNA EXPORT by IZAURRALDE E (1995)
  46. IZAURRALDE E, SEMIN CELL BIOL 3, 279 (1992). (10.1016/1043-4682(92)90029-U) / SEMIN CELL BIOL by IZAURRALDE E (1992)
  47. JARMOLOWSKI A, NUCLEAR EXPORT OF DIFFERENT CLASSES OF RNA IS MEDIATED BY SPECIFIC FACTORS, JOURNAL OF CELL BIOLOGY 124, 627 (1994). (10.1083/jcb.124.5.627) / JOURNAL OF CELL BIOLOGY / NUCLEAR EXPORT OF DIFFERENT CLASSES OF RNA IS MEDIATED BY SPECIFIC FACTORS by JARMOLOWSKI A (1994)
  48. KALDERON D, SEQUENCE REQUIREMENTS FOR NUCLEAR LOCATION OF SIMIAN VIRUS-40 LARGE-T-ANTIGEN, NATURE 311, 33 (1984). (10.1038/311033a0) / NATURE / SEQUENCE REQUIREMENTS FOR NUCLEAR LOCATION OF SIMIAN VIRUS-40 LARGE-T-ANTIGEN by KALDERON D (1984)
  49. KRAEMER D, THE HUMAN CAN PROTEIN, A PUTATIVE ONCOGENE PRODUCT ASSOCIATED WITH MYELOID LEUKEMOGENESIS, IS A NUCLEAR-PORE COMPLEX PROTEIN THAT FACES THE CYTOPLASM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 1519 (1994). (10.1073/pnas.91.4.1519) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / THE HUMAN CAN PROTEIN, A PUTATIVE ONCOGENE PRODUCT ASSOCIATED WITH MYELOID LEUKEMOGENESIS, IS A NUCLEAR-PORE COMPLEX PROTEIN THAT FACES THE CYTOPLASM by KRAEMER D (1994)
  50. KRAEMER M. D., THE ESSENTIAL YEAST NUCLEOPORIN NUP159 IS LOCATED ON THE CYTOPLASMIC SIDE OF THE NUCLEAR-PORE COMPLEX AND SERVES IN KARYOPHERIN-MEDIATED BINDING OF TRANSPORT SUBSTRATE, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 19017 (1995). (10.1074/jbc.270.32.19017) / JOURNAL OF BIOLOGICAL CHEMISTRY / THE ESSENTIAL YEAST NUCLEOPORIN NUP159 IS LOCATED ON THE CYTOPLASMIC SIDE OF THE NUCLEAR-PORE COMPLEX AND SERVES IN KARYOPHERIN-MEDIATED BINDING OF TRANSPORT SUBSTRATE by KRAEMER M. D. (1995)
  51. KUSSEL P, PENDULIN, A DROSOPHILA PROTEIN WITH CELL CYCLE-DEPENDENT NUCLEAR-LOCALIZATION, IS REQUIRED FOR NORMAL-CELL PROLIFERATION, JOURNAL OF CELL BIOLOGY 129, 1491 (1995). (10.1083/jcb.129.6.1491) / JOURNAL OF CELL BIOLOGY / PENDULIN, A DROSOPHILA PROTEIN WITH CELL CYCLE-DEPENDENT NUCLEAR-LOCALIZATION, IS REQUIRED FOR NORMAL-CELL PROLIFERATION by KUSSEL P (1995)
  52. LANFORD E. R., CONSTRUCTION AND CHARACTERIZATION OF AN SV40 MUTANT DEFECTIVE IN NUCLEAR TRANSPORT OF T-ANTIGEN, CELL 37, 801 (1984). (10.1016/0092-8674(84)90415-X) / CELL / CONSTRUCTION AND CHARACTERIZATION OF AN SV40 MUTANT DEFECTIVE IN NUCLEAR TRANSPORT OF T-ANTIGEN by LANFORD E. R. (1984)
  53. LANFORD E. R., INDUCTION OF NUCLEAR TRANSPORT WITH A SYNTHETIC PEPTIDE HOMOLOGOUS TO THE SV40 T-ANTIGEN TRANSPORT SIGNAL, CELL 46, 575 (1986). (10.1016/0092-8674(86)90883-4) / CELL / INDUCTION OF NUCLEAR TRANSPORT WITH A SYNTHETIC PEPTIDE HOMOLOGOUS TO THE SV40 T-ANTIGEN TRANSPORT SIGNAL by LANFORD E. R. (1986)
  54. LEGRAIN P, SOME CIS-ACTING AND TRANS-ACTING MUTANTS FOR SPLICING TARGET PRE-MESSENGER RNA TO THE CYTOPLASM, CELL 57, 573 (1989). (10.1016/0092-8674(89)90127-X) / CELL / SOME CIS-ACTING AND TRANS-ACTING MUTANTS FOR SPLICING TARGET PRE-MESSENGER RNA TO THE CYTOPLASM by LEGRAIN P (1989)
  55. LIU D. X., HNRNP-L BINDS A CIS-ACTING RNA SEQUENCE ELEMENT THAT ENABLES INTRON-INDEPENDENT GENE-EXPRESSION, GENES & DEVELOPMENT 9, 1766 (1995). (10.1101/gad.9.14.1766) / GENES & DEVELOPMENT / HNRNP-L BINDS A CIS-ACTING RNA SEQUENCE ELEMENT THAT ENABLES INTRON-INDEPENDENT GENE-EXPRESSION by LIU D. X. (1995)
  56. MEICHIOR F, J CELL BIOL 131, 571 (1995). (10.1083/jcb.131.3.571) / J CELL BIOL by MEICHIOR F (1995)
  57. MELCHIOR F, INHIBITION OF NUCLEAR-PROTEIN IMPORT BY NONHYDROLYZABLE ANALOGS OF GTP AND IDENTIFICATION OF THE SMALL GTPASE RAN/TC4 AS AN ESSENTIAL TRANSPORT FACTOR, JOURNAL OF CELL BIOLOGY 123, 1649 (1993). / JOURNAL OF CELL BIOLOGY / INHIBITION OF NUCLEAR-PROTEIN IMPORT BY NONHYDROLYZABLE ANALOGS OF GTP AND IDENTIFICATION OF THE SMALL GTPASE RAN/TC4 AS AN ESSENTIAL TRANSPORT FACTOR by MELCHIOR F (1993)
  58. MICHAEL M. W., A NUCLEAR EXPORT SIGNAL IN HNRNP A1 - A SIGNAL-MEDIATED, TEMPERATURE-DEPENDENT NUCLEAR-PROTEIN EXPORT PATHWAY, CELL 83, 415 (1995). (10.1016/0092-8674(95)90119-1) / CELL / A NUCLEAR EXPORT SIGNAL IN HNRNP A1 - A SIGNAL-MEDIATED, TEMPERATURE-DEPENDENT NUCLEAR-PROTEIN EXPORT PATHWAY by MICHAEL M. W. (1995)
  59. MICHAUD N, MULTIPLE PATHWAYS IN NUCLEAR TRANSPORT - THE IMPORT OF U2 SNRNP OCCURS BY A NOVEL KINETIC PATHWAY, JOURNAL OF CELL BIOLOGY 112, 215 (1991). (10.1083/jcb.112.2.215) / JOURNAL OF CELL BIOLOGY / MULTIPLE PATHWAYS IN NUCLEAR TRANSPORT - THE IMPORT OF U2 SNRNP OCCURS BY A NOVEL KINETIC PATHWAY by MICHAUD N (1991)
  60. MOORE S. M., THE 2 STEPS OF NUCLEAR IMPORT, TARGETING TO THE NUCLEAR-ENVELOPE AND TRANSLOCATION THROUGH THE NUCLEAR-PORE, REQUIRE DIFFERENT CYTOSOLIC FACTORS, CELL 69, 939 (1992). (10.1016/0092-8674(92)90613-H) / CELL / THE 2 STEPS OF NUCLEAR IMPORT, TARGETING TO THE NUCLEAR-ENVELOPE AND TRANSLOCATION THROUGH THE NUCLEAR-PORE, REQUIRE DIFFERENT CYTOSOLIC FACTORS by MOORE S. M. (1992)
  61. MOORE S. M., THE GTP-BINDING PROTEIN RAN/TC4 IS REQUIRED FOR PROTEIN IMPORT INTO THE NUCLEUS, NATURE 365, 661 (1993). (10.1038/365661a0) / NATURE / THE GTP-BINDING PROTEIN RAN/TC4 IS REQUIRED FOR PROTEIN IMPORT INTO THE NUCLEUS by MOORE S. M. (1993)
  62. MOORE S. M., PURIFICATION OF A RAN-INTERACTING PROTEIN THAT IS REQUIRED FOR PROTEIN IMPORT INTO THE NUCLEUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 10212 (1994). (10.1073/pnas.91.21.10212) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / PURIFICATION OF A RAN-INTERACTING PROTEIN THAT IS REQUIRED FOR PROTEIN IMPORT INTO THE NUCLEUS by MOORE S. M. (1994)
  63. MOROIANU J, MAMMALIAN KARYOPHERIN ALPHA(1)BETA AND ALPHA(2)BETA HETERODIMERS - ALPHA(1) OR ALPHA(2) SUBUNIT BINDS NUCLEAR-LOCALIZATION SIGNAL AND BETA-SUBUNIT INTERACTS WITH PEPTIDE REPEAT-CONTAINING NUCLEOPORINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 6532 (1995). (10.1073/pnas.92.14.6532) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / MAMMALIAN KARYOPHERIN ALPHA(1)BETA AND ALPHA(2)BETA HETERODIMERS - ALPHA(1) OR ALPHA(2) SUBUNIT BINDS NUCLEAR-LOCALIZATION SIGNAL AND BETA-SUBUNIT INTERACTS WITH PEPTIDE REPEAT-CONTAINING NUCLEOPORINS by MOROIANU J (1995)
  64. NEWMEYER D. D., NUCLEAR IMPORT CAN BE SEPARATED INTO DISTINCT STEPS INVITRO - NUCLEAR-PORE BINDING AND TRANSLOCATION, CELL 52, 641 (1988). (10.1016/0092-8674(88)90402-3) / CELL / NUCLEAR IMPORT CAN BE SEPARATED INTO DISTINCT STEPS INVITRO - NUCLEAR-PORE BINDING AND TRANSLOCATION by NEWMEYER D. D. (1988)
  65. NEWMEYER D. D., ASSEMBLY INVITRO OF NUCLEI ACTIVE IN NUCLEAR-PROTEIN TRANSPORT - ATP IS REQUIRED FOR NUCLEOPLASMIN ACCUMULATION, EMBO JOURNAL 5, 501 (1986). (10.1002/j.1460-2075.1986.tb04239.x) / EMBO JOURNAL / ASSEMBLY INVITRO OF NUCLEI ACTIVE IN NUCLEAR-PROTEIN TRANSPORT - ATP IS REQUIRED FOR NUCLEOPLASMIN ACCUMULATION by NEWMEYER D. D. (1986)
  66. PASCHAL M. B., IDENTIFICATION OF NTF2, A CYTOSOLIC FACTOR FOR NUCLEAR IMPORT THAT INTERACTS WITH NUCLEAR-PORE COMPLEX PROTEIN P62, JOURNAL OF CELL BIOLOGY 129, 925 (1995). (10.1083/jcb.129.4.925) / JOURNAL OF CELL BIOLOGY / IDENTIFICATION OF NTF2, A CYTOSOLIC FACTOR FOR NUCLEAR IMPORT THAT INTERACTS WITH NUCLEAR-PORE COMPLEX PROTEIN P62 by PASCHAL M. B. (1995)
  67. PEIFER M, A REPEATING AMINO-ACID MOTIF SHARED BY PROTEINS WITH DIVERSE CELLULAR ROLES, CELL 76, 789 (1994). (10.1016/0092-8674(94)90353-0) / CELL / A REPEATING AMINO-ACID MOTIF SHARED BY PROTEINS WITH DIVERSE CELLULAR ROLES by PEIFER M (1994)
  68. PINOLROMA S, SHUTTLING OF PRE-MESSENGER-RNA BINDING-PROTEINS BETWEEN NUCLEUS AND CYTOPLASM, NATURE 355, 730 (1992). (10.1038/355730a0) / NATURE / SHUTTLING OF PRE-MESSENGER-RNA BINDING-PROTEINS BETWEEN NUCLEUS AND CYTOPLASM by PINOLROMA S (1992)
  69. PINOLROMA S, TRANSCRIPTION-DEPENDENT AND TRANSCRIPTION-INDEPENDENT NUCLEAR TRANSPORT OF HNRNP PROTEINS, SCIENCE 253, 312 (1991). (10.1126/science.1857966) / SCIENCE / TRANSCRIPTION-DEPENDENT AND TRANSCRIPTION-INDEPENDENT NUCLEAR TRANSPORT OF HNRNP PROTEINS by PINOLROMA S (1991)
  70. POKRYWKA J. N., NUCLEAR EXPORT PATHWAYS OF TRANSFER-RNA AND 40-S RIBOSOMES INCLUDE BOTH COMMON AND SPECIFIC INTERMEDIATES, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 3619 (1995). (10.1074/jbc.270.8.3619) / JOURNAL OF BIOLOGICAL CHEMISTRY / NUCLEAR EXPORT PATHWAYS OF TRANSFER-RNA AND 40-S RIBOSOMES INCLUDE BOTH COMMON AND SPECIFIC INTERMEDIATES by POKRYWKA J. N. (1995)
  71. RADU A, THE PEPTIDE REPEAT DOMAIN OF NUCLEOPORIN NUP98 FUNCTIONS AS A DOCKING SITE IN TRANSPORT ACROSS THE NUCLEAR-PORE COMPLEX, CELL 81, 215 (1995). (10.1016/0092-8674(95)90331-3) / CELL / THE PEPTIDE REPEAT DOMAIN OF NUCLEOPORIN NUP98 FUNCTIONS AS A DOCKING SITE IN TRANSPORT ACROSS THE NUCLEAR-PORE COMPLEX by RADU A (1995)
  72. RADU A, IDENTIFICATION OF A PROTEIN COMPLEX THAT IS REQUIRED FOR NUCLEAR-PROTEIN IMPORT AND MEDIATES DOCKING OF IMPORT SUBSTRATE TO DISTINCT NUCLEOPORINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 1769 (1995). (10.1073/pnas.92.5.1769) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / IDENTIFICATION OF A PROTEIN COMPLEX THAT IS REQUIRED FOR NUCLEAR-PROTEIN IMPORT AND MEDIATES DOCKING OF IMPORT SUBSTRATE TO DISTINCT NUCLEOPORINS by RADU A (1995)
  73. REXACH M, PROTEIN IMPORT INTO NUCLEI - ASSOCIATION AND DISSOCIATION REACTIONS INVOLVING TRANSPORT SUBSTRATE, TRANSPORT FACTORS, AND NUCLEOPORINS, CELL 83, 683 (1995). (10.1016/0092-8674(95)90181-7) / CELL / PROTEIN IMPORT INTO NUCLEI - ASSOCIATION AND DISSOCIATION REACTIONS INVOLVING TRANSPORT SUBSTRATE, TRANSPORT FACTORS, AND NUCLEOPORINS by REXACH M (1995)
  74. RICHARDS A. S., THE C-TERMINUS OF THE NUCLEAR RAN/TC4 GTPASE STABILIZES THE GDP-BOUND STATE AND MEDIATES INTERACTIONS WITH RCC1, RAN-GAP, AND HTF9A/RANBP1, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 14405 (1995). (10.1074/jbc.270.24.14405) / JOURNAL OF BIOLOGICAL CHEMISTRY / THE C-TERMINUS OF THE NUCLEAR RAN/TC4 GTPASE STABILIZES THE GDP-BOUND STATE AND MEDIATES INTERACTIONS WITH RCC1, RAN-GAP, AND HTF9A/RANBP1 by RICHARDS A. S. (1995)
  75. RICHARDSON D. W., NUCLEAR-PROTEIN MIGRATION INVOLVES 2 STEPS - RAPID BINDING AT THE NUCLEAR-ENVELOPE FOLLOWED BY SLOWER TRANSLOCATION THROUGH NUCLEAR-PORES, CELL 52, 655 (1988). (10.1016/0092-8674(88)90403-5) / CELL / NUCLEAR-PROTEIN MIGRATION INVOLVES 2 STEPS - RAPID BINDING AT THE NUCLEAR-ENVELOPE FOLLOWED BY SLOWER TRANSLOCATION THROUGH NUCLEAR-PORES by RICHARDSON D. W. (1988)
  76. ROBBINS J, 2 INTERDEPENDENT BASIC DOMAINS IN NUCLEOPLASMIN NUCLEAR TARGETING SEQUENCE - IDENTIFICATION OF A CLASS OF BIPARTITE NUCLEAR TARGETING SEQUENCE, CELL 64, 615 (1991). (10.1016/0092-8674(91)90245-T) / CELL / 2 INTERDEPENDENT BASIC DOMAINS IN NUCLEOPLASMIN NUCLEAR TARGETING SEQUENCE - IDENTIFICATION OF A CLASS OF BIPARTITE NUCLEAR TARGETING SEQUENCE by ROBBINS J (1991)
  77. ROUT P. M., TRENDS CELL BIOL 4, 357 (1994). (10.1016/0962-8924(94)90085-X) / TRENDS CELL BIOL by ROUT P. M. (1994)
  78. SCHLENSTEDT G, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92, 255 (1995). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA by SCHLENSTEDT G (1995)
  79. SHATKIN J. A., CAPPING OF EUKARYOTIC MESSENGER-RNAS, CELL 9, 645 (1976). / CELL / CAPPING OF EUKARYOTIC MESSENGER-RNAS by SHATKIN J. A. (1976)
  80. STUTZ F, IDENTIFICATION OF A NOVEL NUCLEAR PORE-ASSOCIATED PROTEIN AS A FUNCTIONAL TARGET OF THE HIV-1 REV PROTEIN IN YEAST, CELL 82, 495 (1995). (10.1016/0092-8674(95)90438-7) / CELL / IDENTIFICATION OF A NOVEL NUCLEAR PORE-ASSOCIATED PROTEIN AS A FUNCTIONAL TARGET OF THE HIV-1 REV PROTEIN IN YEAST by STUTZ F (1995)
  81. STUTZ F, A FUNCTIONAL INTERACTION BETWEEN REV AND YEAST PRE-MESSENGER-RNA IS RELATED TO SPLICING COMPLEX-FORMATION, EMBO JOURNAL 13, 4096 (1994). (10.1002/j.1460-2075.1994.tb06727.x) / EMBO JOURNAL / A FUNCTIONAL INTERACTION BETWEEN REV AND YEAST PRE-MESSENGER-RNA IS RELATED TO SPLICING COMPLEX-FORMATION by STUTZ F (1994)
  82. 10.1038/365721a0
  83. TOROK I, THE OVERGROWN HEMATOPOIETIC ORGANS-31 TUMOR-SUPPRESSOR GENE OF DROSOPHILA ENCODES AN IMPORTIN-LIKE PROTEIN ACCUMULATING IN THE NUCLEUS AT THE ONSET OF MITOSIS, JOURNAL OF CELL BIOLOGY 129, 1473 (1995). (10.1083/jcb.129.6.1473) / JOURNAL OF CELL BIOLOGY / THE OVERGROWN HEMATOPOIETIC ORGANS-31 TUMOR-SUPPRESSOR GENE OF DROSOPHILA ENCODES AN IMPORTIN-LIKE PROTEIN ACCUMULATING IN THE NUCLEUS AT THE ONSET OF MITOSIS by TOROK I (1995)
  84. VISA N, IN PRESS J CELL BIOL . / IN PRESS J CELL BIOL by VISA N
  85. VONLINDERN M, CAN, A PUTATIVE ONCOGENE ASSOCIATED WITH MYELOID LEUKEMOGENESIS, MAY BE ACTIVATED BY FUSION OF ITS 3′ 1/2 TO DIFFERENT GENES - CHARACTERIZATION OF THE SET GENE, MOLECULAR AND CELLULAR BIOLOGY 12, 3346 (1992). / MOLECULAR AND CELLULAR BIOLOGY / CAN, A PUTATIVE ONCOGENE ASSOCIATED WITH MYELOID LEUKEMOGENESIS, MAY BE ACTIVATED BY FUSION OF ITS 3′ 1/2 TO DIFFERENT GENES - CHARACTERIZATION OF THE SET GENE by VONLINDERN M (1992)
  86. WARE C. V., RIBOSOME STRUCTURE F (1991). / RIBOSOME STRUCTURE F by WARE C. V. (1991)
  87. WEIS K, IN PRESS EMBO J . / IN PRESS EMBO J by WEIS K
  88. WEIS K, IDENTIFICATION OF HSRP1-ALPHA AS A FUNCTIONAL RECEPTOR FOR NUCLEAR-LOCALIZATION SEQUENCES, SCIENCE 268, 1049 (1995). (10.1126/science.7754385) / SCIENCE / IDENTIFICATION OF HSRP1-ALPHA AS A FUNCTIONAL RECEPTOR FOR NUCLEAR-LOCALIZATION SEQUENCES by WEIS K (1995)
  89. WEIS K unpublished data.
  90. 10.1016/0092-8674(95)90435-2
  91. WU J, NUP358, A CYTOPLASMICALLY EXPOSED NUCLEOPORIN WITH PEPTIDE REPEATS, RAN-GTP BINDING-SITES, ZINC FINGERS, A CYCLOPHILIN-A HOMOLOGOUS DOMAIN, AND A LEUCINE-RICH REGION, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 14209 (1995). (10.1074/jbc.270.23.14209) / JOURNAL OF BIOLOGICAL CHEMISTRY / NUP358, A CYTOPLASMICALLY EXPOSED NUCLEOPORIN WITH PEPTIDE REPEATS, RAN-GTP BINDING-SITES, ZINC FINGERS, A CYCLOPHILIN-A HOMOLOGOUS DOMAIN, AND A LEUCINE-RICH REGION by WU J (1995)
  92. YANO R, CLONING AND CHARACTERIZATION OF SRP1, A SUPPRESSOR OF TEMPERATURE-SENSITIVE RNA POLYMERASE-I MUTATIONS, IN SACCHAROMYCES-CEREVISIAE, MOLECULAR AND CELLULAR BIOLOGY 12, 5640 (1992). / MOLECULAR AND CELLULAR BIOLOGY / CLONING AND CHARACTERIZATION OF SRP1, A SUPPRESSOR OF TEMPERATURE-SENSITIVE RNA POLYMERASE-I MUTATIONS, IN SACCHAROMYCES-CEREVISIAE by YANO R (1992)
  93. 10.1038/376184a0
  94. ZASLOFF M, TRANSFER-RNA TRANSPORT FROM THE NUCLEUS IN A EUKARYOTIC CELL - CARRIER-MEDIATED TRANSLOCATION PROCESS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80, 6436 (1983). (10.1073/pnas.80.21.6436) / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES / TRANSFER-RNA TRANSPORT FROM THE NUCLEUS IN A EUKARYOTIC CELL - CARRIER-MEDIATED TRANSLOCATION PROCESS by ZASLOFF M (1983)
Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:27 p.m.)
Indexed 3 days, 4 hours ago (Aug. 19, 2025, 6:35 a.m.)
Issued 29 years, 5 months ago (March 15, 1996)
Published 29 years, 5 months ago (March 15, 1996)
Published Print 29 years, 5 months ago (March 15, 1996)
Funders 0

None

@article{G_rlich_1996, title={Nucleocytoplasmic Transport}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5255.1513}, DOI={10.1126/science.271.5255.1513}, number={5255}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Görlich, Dirk and Mattaj, Iain W.}, year={1996}, month=mar, pages={1513–1519} }