DOI: 10.1126/science.271.5253.1291. HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV

HIV-1 Langerhans' Cell Tropism Associated with Heterosexual Transmission of HIV

10.1126/science.271.5253.1291

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.

Bibliography

Soto-Ramirez, L. E., Renjifo, B., McLane, M. F., Marlink, R., OâHara, C., Sutthent, R., Wasi, C., Vithayasai, P., Vithayasai, V., Apichartpiyakul, C., Auewarakul, P., Cruz, V. P., Chui, D.-S., Osathanondh, R., Mayer, K., Lee, T.-H., & Essex, M. (1996). HIV-1 Langerhansâ Cell Tropism Associated with Heterosexual Transmission of HIV. Science, 271(5253), 1291â1293.

Authors 17

Luis E. Soto-Ramirez (first)
Boris Renjifo (additional)
Mary F. McLane (additional)
Richard Marlink (additional)
Carl O'Hara (additional)
Ruengpung Sutthent (additional)
Chantapong Wasi (additional)
Prakong Vithayasai (additional)
Vicharn Vithayasai (additional)
Chatchawann Apichartpiyakul (additional)
Prasert Auewarakul (additional)
Victor Peña Cruz (additional)
Dao-Shan Chui (additional)
Rapin Osathanondh (additional)
Kenneth Mayer (additional)
Tun-Hou Lee (additional)
Max Essex (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:31 p.m.)
Indexed	4 months, 2 weeks ago (April 10, 2025, 7:29 a.m.)
Issued	29 years, 5 months ago (March 1, 1996)
Published	29 years, 5 months ago (March 1, 1996)
Published Print	29 years, 5 months ago (March 1, 1996)

Funders 0

None

BibTeX

@article{Soto_Ramirez_1996, title={HIV-1 Langerhans’ Cell Tropism Associated with Heterosexual Transmission of HIV}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5253.1291}, DOI={10.1126/science.271.5253.1291}, number={5253}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Soto-Ramirez, Luis E. and Renjifo, Boris and McLane, Mary F. and Marlink, Richard and O’Hara, Carl and Sutthent, Ruengpung and Wasi, Chantapong and Vithayasai, Prakong and Vithayasai, Vicharn and Apichartpiyakul, Chatchawann and Auewarakul, Prasert and Cruz, Victor Peña and Chui, Dao-Shan and Osathanondh, Rapin and Mayer, Kenneth and Lee, Tun-Hou and Essex, Max}, year={1996}, month=mar, pages={1291–1293} }

JSON

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