Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3
10.1126/science.271.5248.521
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Two apoptosis-linked genes, named ALG-2 and ALG-3 , were identified by means of a functional selection strategy. ALG-2 codes for a Ca 2+ -binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3 , a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2 , rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca 2+ -regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.

Bibliography

Vito, P., Lacaná, E., & D’Adamio, L. (1996). Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer’s Disease Gene ALG-3. Science, 271(5248), 521–525.

Authors 3
  1. Pasquale Vito (first)
  2. Emanuela Lacaná (additional)
  3. Luciano D'Adamio (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 6:10 p.m.)
Indexed 2 months, 2 weeks ago (June 10, 2025, 1:48 p.m.)
Issued 29 years, 7 months ago (Jan. 26, 1996)
Published 29 years, 7 months ago (Jan. 26, 1996)
Published Print 29 years, 7 months ago (Jan. 26, 1996)
Funders 0

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@article{Vito_1996, title={Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer’s Disease Gene ALG-3}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5248.521}, DOI={10.1126/science.271.5248.521}, number={5248}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Vito, Pasquale and Lacaná, Emanuela and D’Adamio, Luciano}, year={1996}, month=jan, pages={521–525} }