DOI: 10.1126/science.271.5247.314. Checkpoints Take the Next Step

10.1126/science.271.5247.314

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Checkpoints are times during the cell cycle when the cell can choose to pause if something is amiss—if its DNA is damaged or if there is a mistake in the synthesis of the new DNA—so that the damage can be repaired. The proteins of these pathways have been defined genetically. Now Carr discusses new biochemical evidence from yeast, presented in two papers in this week's issue of Science (p p. 353 and p. 357 ), that start to elucidate the functions of two of these proteins—Chk1 and Rad3.

Bibliography

Carr, A. M. (1996). Checkpoints Take the Next Step. Science, 271(5247), 314â315.

Authors 1

Antony M. Carr (first)

References 13 Referenced 38

ALKHODAIRY F, IDENTIFICATION AND CHARACTERIZATION OF NEW ELEMENTS INVOLVED IN CHECKPOINT AND FEEDBACK CONTROLS IN FISSION YEAST, MOLECULAR BIOLOGY OF THE CELL 5, 147 (1994). (10.1091/mbc.5.2.147) / MOLECULAR BIOLOGY OF THE CELL / IDENTIFICATION AND CHARACTERIZATION OF NEW ELEMENTS INVOLVED IN CHECKPOINT AND FEEDBACK CONTROLS IN FISSION YEAST by ALKHODAIRY F (1994)
CARR M. A., THE CELLULAR-RESPONSES TO DNA-DAMAGE, TRENDS IN CELL BIOLOGY 5, 32 (1995). (10.1016/S0962-8924(00)88934-5) / TRENDS IN CELL BIOLOGY / THE CELLULAR-RESPONSES TO DNA-DAMAGE by CARR M. A. (1995)
CARR M. A. unpublished data.
FORD C. J., 14-3-3-PROTEIN HOMOLOGS REQUIRED FOR THE DNA-DAMAGE CHECKPOINT IN FISSION YEAST, SCIENCE 265, 533 (1994). (10.1126/science.8036497) / SCIENCE / 14-3-3-PROTEIN HOMOLOGS REQUIRED FOR THE DNA-DAMAGE CHECKPOINT IN FISSION YEAST by FORD C. J. (1994)
LU X, DIFFERENTIAL INDUCTION OF TRANSCRIPTIONALLY ACTIVE P53 FOLLOWING UV OR IONIZING-RADIATION - DEFECTS IN CHROMOSOME INSTABILITY SYNDROMES, CELL 75, 765 (1993). (10.1016/0092-8674(93)90496-D) / CELL / DIFFERENTIAL INDUCTION OF TRANSCRIPTIONALLY ACTIVE P53 FOLLOWING UV OR IONIZING-RADIATION - DEFECTS IN CHROMOSOME INSTABILITY SYNDROMES by LU X (1993)
LYDALL D, YEAST CHECKPOINT GENES IN DNA-DAMAGE PROCESSING - IMPLICATIONS FOR REPAIR AND ARREST, SCIENCE 270, 1488 (1995). (10.1126/science.270.5241.1488) / SCIENCE / YEAST CHECKPOINT GENES IN DNA-DAMAGE PROCESSING - IMPLICATIONS FOR REPAIR AND ARREST by LYDALL D (1995)
MORROW M. D., TEL1, AN SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE HUMAN GENE MUTATED IN ATAXIA-TELANGIECTASIA, IS FUNCTIONALLY RELATED TO THE YEAST CHECKPOINT GENE MEC1, CELL 82, 831 (1995). (10.1016/0092-8674(95)90480-8) / CELL / TEL1, AN SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE HUMAN GENE MUTATED IN ATAXIA-TELANGIECTASIA, IS FUNCTIONALLY RELATED TO THE YEAST CHECKPOINT GENE MEC1 by MORROW M. D. (1995)
10.1126/science.271.5247.357
10.1126/science.7792600
WALWORTH N, FISSION YEAST CHK1-PROTEIN KINASE LINKS THE RAD CHECKPOINT PATHWAY TO CDC2, NATURE 363, 368 (1993). (10.1038/363368a0) / NATURE / FISSION YEAST CHK1-PROTEIN KINASE LINKS THE RAD CHECKPOINT PATHWAY TO CDC2 by WALWORTH N (1993)
10.1126/science.271.5247.353
10.1126/science.3291120
ZAKIAN A. V., ATM-RELATED GENES - WHAT DO THEY TELL US ABOUT FUNCTIONS OF THE HUMAN GENE, CELL 82, 685 (1995). (10.1016/0092-8674(95)90463-8) / CELL / ATM-RELATED GENES - WHAT DO THEY TELL US ABOUT FUNCTIONS OF THE HUMAN GENE by ZAKIAN A. V. (1995)

Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:30 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 6:13 p.m.)
Indexed	1 year, 6 months ago (Feb. 1, 2024, 10:40 p.m.)
Issued	29 years, 7 months ago (Jan. 19, 1996)
Published	29 years, 7 months ago (Jan. 19, 1996)
Published Print	29 years, 7 months ago (Jan. 19, 1996)

Funders 0

None

BibTeX

@article{Carr_1996, title={Checkpoints Take the Next Step}, volume={271}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.271.5247.314}, DOI={10.1126/science.271.5247.314}, number={5247}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Carr, Antony M.}, year={1996}, month=jan, pages={314–315} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        2,
        2
      ]
    ],
    "date-time": "2024-02-02T03:40:34Z",
    "timestamp": 1706845234239
  },
  "reference-count": 13,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "5247",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        1,
        19
      ]
    ]
  },
  "abstract": "<jats:p>\n            Checkpoints are times during the cell cycle when the cell can choose to pause if something is amiss\u2014if its DNA is damaged or if there is a mistake in the synthesis of the new DNA\u2014so that the damage can be repaired. The proteins of these pathways have been defined genetically. Now Carr discusses new biochemical evidence from yeast, presented in two papers in this week's issue of\n            <jats:italic>Science</jats:italic>\n            (p\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"353\" related-article-type=\"in-this-issue\" vol=\"271\" xlink:href=\"10.1126/science.271.5247.353\" xlink:type=\"simple\">p. 353</jats:related-article>\n            and\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"357\" related-article-type=\"in-this-issue\" vol=\"271\" xlink:href=\"10.1126/science.271.5247.357\" xlink:type=\"simple\">p. 357</jats:related-article>\n            ), that start to elucidate the functions of two of these proteins\u2014Chk1 and Rad3.\n          </jats:p>",
  "DOI": "10.1126/science.271.5247.314",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        27
      ]
    ],
    "date-time": "2006-10-27T18:30:41Z",
    "timestamp": 1161973841000
  },
  "page": "314-315",
  "source": "Crossref",
  "is-referenced-by-count": 38,
  "title": "Checkpoints Take the Next Step",
  "prefix": "10.1126",
  "volume": "271",
  "author": [
    {
      "given": "Antony M.",
      "family": "Carr",
      "sequence": "first",
      "affiliation": [
        {
          "name": "The author is in the Medical Research Council Cell Mutation Unit, Sussex University, BN1 9RR, UK."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1091/mbc.5.2.147",
      "article-title": "IDENTIFICATION AND CHARACTERIZATION OF NEW ELEMENTS INVOLVED IN CHECKPOINT AND FEEDBACK CONTROLS IN FISSION YEAST",
      "volume": "5",
      "author": "ALKHODAIRY F",
      "year": "1994",
      "unstructured": "ALKHODAIRY F, IDENTIFICATION AND CHARACTERIZATION OF NEW ELEMENTS INVOLVED IN CHECKPOINT AND FEEDBACK CONTROLS IN FISSION YEAST, MOLECULAR BIOLOGY OF THE CELL 5, 147 (1994).",
      "journal-title": "MOLECULAR BIOLOGY OF THE CELL"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "crossref",
      "first-page": "32",
      "DOI": "10.1016/S0962-8924(00)88934-5",
      "article-title": "THE CELLULAR-RESPONSES TO DNA-DAMAGE",
      "volume": "5",
      "author": "CARR M. A.",
      "year": "1995",
      "unstructured": "CARR M. A., THE CELLULAR-RESPONSES TO DNA-DAMAGE, TRENDS IN CELL BIOLOGY 5, 32 (1995).",
      "journal-title": "TRENDS IN CELL BIOLOGY"
    },
    {
      "key": "e_1_2_1_4_2",
      "unstructured": "CARR M. A. unpublished data."
    },
    {
      "key": "e_1_2_1_5_2",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1126/science.8036497",
      "article-title": "14-3-3-PROTEIN HOMOLOGS REQUIRED FOR THE DNA-DAMAGE CHECKPOINT IN FISSION YEAST",
      "volume": "265",
      "author": "FORD C. J.",
      "year": "1994",
      "unstructured": "FORD C. J., 14-3-3-PROTEIN HOMOLOGS REQUIRED FOR THE DNA-DAMAGE CHECKPOINT IN FISSION YEAST, SCIENCE 265, 533 (1994).",
      "journal-title": "SCIENCE"
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "crossref",
      "first-page": "765",
      "DOI": "10.1016/0092-8674(93)90496-D",
      "article-title": "DIFFERENTIAL INDUCTION OF TRANSCRIPTIONALLY ACTIVE P53 FOLLOWING UV OR IONIZING-RADIATION - DEFECTS IN CHROMOSOME INSTABILITY SYNDROMES",
      "volume": "75",
      "author": "LU X",
      "year": "1993",
      "unstructured": "LU X, DIFFERENTIAL INDUCTION OF TRANSCRIPTIONALLY ACTIVE P53 FOLLOWING UV OR IONIZING-RADIATION - DEFECTS IN CHROMOSOME INSTABILITY SYNDROMES, CELL 75, 765 (1993).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "crossref",
      "first-page": "1488",
      "DOI": "10.1126/science.270.5241.1488",
      "article-title": "YEAST CHECKPOINT GENES IN DNA-DAMAGE PROCESSING - IMPLICATIONS FOR REPAIR AND ARREST",
      "volume": "270",
      "author": "LYDALL D",
      "year": "1995",
      "unstructured": "LYDALL D, YEAST CHECKPOINT GENES IN DNA-DAMAGE PROCESSING - IMPLICATIONS FOR REPAIR AND ARREST, SCIENCE 270, 1488 (1995).",
      "journal-title": "SCIENCE"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1016/0092-8674(95)90480-8",
      "article-title": "TEL1, AN SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE HUMAN GENE MUTATED IN ATAXIA-TELANGIECTASIA, IS FUNCTIONALLY RELATED TO THE YEAST CHECKPOINT GENE MEC1",
      "volume": "82",
      "author": "MORROW M. D.",
      "year": "1995",
      "unstructured": "MORROW M. D., TEL1, AN SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE HUMAN GENE MUTATED IN ATAXIA-TELANGIECTASIA, IS FUNCTIONALLY RELATED TO THE YEAST CHECKPOINT GENE MEC1, CELL 82, 831 (1995).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.271.5247.357"
    },
    {
      "key": "e_1_2_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7792600"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "crossref",
      "first-page": "368",
      "DOI": "10.1038/363368a0",
      "article-title": "FISSION YEAST CHK1-PROTEIN KINASE LINKS THE RAD CHECKPOINT PATHWAY TO CDC2",
      "volume": "363",
      "author": "WALWORTH N",
      "year": "1993",
      "unstructured": "WALWORTH N, FISSION YEAST CHK1-PROTEIN KINASE LINKS THE RAD CHECKPOINT PATHWAY TO CDC2, NATURE 363, 368 (1993).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.271.5247.353"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3291120"
    },
    {
      "key": "e_1_2_1_14_2",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1016/0092-8674(95)90463-8",
      "article-title": "ATM-RELATED GENES - WHAT DO THEY TELL US ABOUT FUNCTIONS OF THE HUMAN GENE",
      "volume": "82",
      "author": "ZAKIAN A. V.",
      "year": "1995",
      "unstructured": "ZAKIAN A. V., ATM-RELATED GENES - WHAT DO THEY TELL US ABOUT FUNCTIONS OF THE HUMAN GENE, CELL 82, 685 (1995).",
      "journal-title": "CELL"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.271.5247.314",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        12
      ]
    ],
    "date-time": "2024-01-12T23:13:11Z",
    "timestamp": 1705101191000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.271.5247.314"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        1,
        19
      ]
    ]
  },
  "references-count": 13,
  "journal-issue": {
    "issue": "5247",
    "published-print": {
      "date-parts": [
        [
          1996,
          1,
          19
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.271.5247.314"
  ],
  "URL": "http://dx.doi.org/10.1126/science.271.5247.314",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1996,
        1,
        19
      ]
    ]
  }
}