DOI: 10.1126/science.2704997. Inescapable versus Escapable Shock Modulates Long-Term Potentiation in the Rat Hippocampus

Inescapable versus Escapable Shock Modulates Long-Term Potentiation in the Rat Hippocampus

10.1126/science.2704997

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A group of rats was trained to escape low-intensity shock in a shuttle-box test, while another group of yoked controls could not escape but was exposed to the same amount and regime of shock. After 1 week of training, long-term potentiation (LTP) was measured in vitro in hippocampal slices. Exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock. These results provide evidence that controllability modulates plasticity at the cellular-neuronal level.

Bibliography

Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F. (1989). Inescapable versus Escapable Shock Modulates Long-Term Potentiation in the Rat Hippocampus. Science, 244(4901), 224â226.

Authors 4

Tracey J. Shors (first)
Thomas B. Seib (additional)
Seymour Levine (additional)
Richard F. Thompson (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:31 p.m.)
Indexed	1 month ago (July 28, 2025, 6:02 p.m.)
Issued	36 years, 4 months ago (April 14, 1989)
Published	36 years, 4 months ago (April 14, 1989)
Published Print	36 years, 4 months ago (April 14, 1989)

Funders 0

None

BibTeX

@article{Shors_1989, title={Inescapable versus Escapable Shock Modulates Long-Term Potentiation in the Rat Hippocampus}, volume={244}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2704997}, DOI={10.1126/science.2704997}, number={4901}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Shors, Tracey J. and Seib, Thomas B. and Levine, Seymour and Thompson, Richard F.}, year={1989}, month=apr, pages={224–226} }

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