DOI: 10.1126/science.2704991. Odor-Induced Membrane Currents in Vertebrate-Olfactory Receptor Neurons

Odor-Induced Membrane Currents in Vertebrate-Olfactory Receptor Neurons

10.1126/science.2704991

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In olfactory receptor neurons, odor molecules cause a depolarization that leads to action potential generation. Underlying the depolarization is an ionic current that is the earliest electrical event in the transduction process. In two preparations, olfactory receptor neurons were voltage-clamped and stimulated with odors and this generator current was measured. In addition, a method was developed to estimate the time course and absolute concentration of odorants delivered to the receptor sites. With this method, olfactory neurons were found to have relatively high stimulus thresholds, steep dose-response relations, long latencies, and an apparent requirement for cooperativity at one or more steps in the pathway from odorant binding to activation of the generator current.

Bibliography

Firestein, S., & Werblin, F. (1989). Odor-Induced Membrane Currents in Vertebrate-Olfactory Receptor Neurons. Science, 244(4900), 79â82.

Authors 2

Stuart Firestein (first)
Frank Werblin (additional)

References 24 Referenced 137

AMOORE, J. E., CHEMICAL SENSES & FLAVOUR 3: 57 (1978). (10.1093/chemse/3.1.57) / CHEMICAL SENSES & FLAVOUR (1978)
ANDERSON, PAV, INTRACELLULAR-RECORDINGS FROM ISOLATED SALAMANDER OLFACTORY RECEPTOR NEURONS, NEUROSCIENCE 21: 167 (1987). (10.1016/0306-4522(87)90330-7) / NEUROSCIENCE (1987)
BAYLOR, D. A., JOURNAL OF PHYSIOLOGY-LONDON 242: 759 (1974). (10.1113/jphysiol.1974.sp010733) / JOURNAL OF PHYSIOLOGY-LONDON (1974)
DIONNE V.E. 9TH INT S OLF TAST S 45 (1986).
Firestein S. Transduction Mechanisms in Taste and Olfaction (1989).
FIRESTEIN, S, GATED CURRENTS IN ISOLATED OLFACTORY RECEPTOR NEURONS OF THE LARVAL TIGER SALAMANDER, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 6292 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
GETCHELL, T. V., JOURNAL OF PHYSIOLOGY-LONDON 282: 541 (1978). (10.1113/jphysiol.1978.sp012480) / JOURNAL OF PHYSIOLOGY-LONDON (1978)
GETCHELL, T.V., PERIRECEPTOR AND RECEPTOR EVENTS IN VERTEBRATE OLFACTION, PROGRESS IN NEUROBIOLOGY 23: 317 (1984). (10.1016/0301-0082(84)90008-X) / PROGRESS IN NEUROBIOLOGY (1984)
10.1007/BF00656997
HARTZELL, H. C., JOURNAL OF PHYSIOLOGY-LONDON 271: 817 (1977). (10.1113/jphysiol.1977.sp012027) / JOURNAL OF PHYSIOLOGY-LONDON (1977)
HUQUE, T, ODORANT AND GUANINE NUCLEOTIDE-STIMULATED PHOSPHOINOSITIDE TURNOVER IN OLFACTORY CILIA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 137: 36 (1986). (10.1016/0006-291X(86)91172-1) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1986)
KEHOE, J, CERTAIN SLOW SYNAPTIC RESPONSES - THEIR PROPERTIES AND POSSIBLE UNDERLYING MECHANISMS, ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING 9: 437 (1980). (10.1146/annurev.bb.09.060180.002253) / ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING (1980)
LABARCA, P, ACTIVATION BY ODORANTS OF A MULTISTATE CATION CHANNEL FROM OLFACTORY CILIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 944 (1988). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1988)
LANCET, D, VERTEBRATE OLFACTORY RECEPTION, ANNUAL REVIEW OF NEUROSCIENCE 9: 329 (1986). (10.1146/annurev.ne.09.030186.001553) / ANNUAL REVIEW OF NEUROSCIENCE (1986)
10.1038/325442a0
10.1038/316255a0
RAFOLS, J.A., MORPHOLOGICAL RELATIONS BETWEEN THE RECEPTOR NEURONS, SUSTENTACULAR CELLS AND SCHWANN-CELLS IN THE OLFACTORY MUCOSA OF THE SALAMANDER, ANATOMICAL RECORD 206: 87 (1983). (10.1002/ar.1092060111) / ANATOMICAL RECORD (1983)
10.1016/S0021-9258(18)66747-X
SUZUKI, N, CYCLIC-NUCLEOTIDES AS INTRACELLULAR MESSENGERS IN THE OLFACTORY TRANSDUCTION PROCESS, CHEMICAL SENSES 13: 311 (1988). (10.1093/chemse/13.2.311) / CHEMICAL SENSES (1988)
SUZUKI N 9TH INT S OLF TAST S 46 (1986). (10.4307/jsee1953.34.2_46)
TROTIER, D, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 407: 589 (1986). (10.1007/BF00582636) / PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (1986)
Weast R. C. Handbook of Chemistry and Physics 69 (1988).
WERBLIN, F. S., JOURNAL OF PHYSIOLOGY-LONDON 264: 767 (1977). (10.1113/jphysiol.1977.sp011693) / JOURNAL OF PHYSIOLOGY-LONDON (1977)
Windholz M. The Merck Index 10 (1983).

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	7 months, 2 weeks ago (Jan. 11, 2025, 2:54 a.m.)
Indexed	4 weeks, 1 day ago (Aug. 3, 2025, 12:30 a.m.)
Issued	36 years, 4 months ago (April 7, 1989)
Published	36 years, 4 months ago (April 7, 1989)
Published Print	36 years, 4 months ago (April 7, 1989)

Funders 0

None

BibTeX

@article{Firestein_1989, title={Odor-Induced Membrane Currents in Vertebrate-Olfactory Receptor Neurons}, volume={244}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2704991}, DOI={10.1126/science.2704991}, number={4900}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Firestein, Stuart and Werblin, Frank}, year={1989}, month=apr, pages={79–82} }

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