DOI: 10.1126/science.270.5244.2008. Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

10.1126/science.270.5244.2008

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-β (TGF-β). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-β and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.

Bibliography

Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., & Matsumoto, K. (1995). Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-Î² Signal Transduction. Science, 270(5244), 2008â2011.

Authors 9

Kyoko Yamaguchi (first)
Kyoko Shirakabe (additional)
Hiroshi Shibuya (additional)
Kenji Irie (additional)
Isao Oishi (additional)
Naoto Ueno (additional)
Tadatsugu Taniguchi (additional)
Eisuke Nishida (additional)
Kunihiro Matsumoto (additional)

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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:44 p.m.)
Indexed	22 minutes ago (Aug. 25, 2025, 7:49 p.m.)
Issued	29 years, 8 months ago (Dec. 22, 1995)
Published	29 years, 8 months ago (Dec. 22, 1995)
Published Print	29 years, 8 months ago (Dec. 22, 1995)

Funders 0

None

BibTeX

@article{Yamaguchi_1995, title={Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5244.2008}, DOI={10.1126/science.270.5244.2008}, number={5244}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yamaguchi, Kyoko and Shirakabe, Kyoko and Shibuya, Hiroshi and Irie, Kenji and Oishi, Isao and Ueno, Naoto and Taniguchi, Tadatsugu and Nishida, Eisuke and Matsumoto, Kunihiro}, year={1995}, month=dec, pages={2008–2011} }

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