DOI: 10.1126/science.270.5243.1811. Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 <sup>+</sup> T Cells

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T Cells

10.1126/science.270.5243.1811

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Evidence suggests that CD8 + T lymphocytes are involved in the control of human immunodeficiency virus (HIV) infection in vivo, either by cytolytic mechanisms or by the release of HIV-suppressive factors (HIV-SF). The chemokines RANTES, MIP-1α, and MIP-1β were identified as the major HIV-SF produced by CD8 + T cells. Two active proteins purified from the culture supernatant of an immortalized CD8 + T cell clone revealed sequence identity with human RANTES and MIP-1α. RANTES, MIP-1α, and MIP-1β were released by both immortalized and primary CD8 + T cells. HIV-SF activity produced by these cells was completely blocked by a combination of neutralizing antibodies against RANTES, MIP-1α, and MIP-1β. Recombinant human RANTES, MIP-1α, and MIP-1β induced a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). These data may have relevance for the prevention and therapy of AIDS.

Bibliography

Cocchi, F., DeVico, A. L., Garzino-Demo, A., Arya, S. K., Gallo, R. C., & Lusso, P. (1995). Identification of RANTES, MIP-1Î±, and MIP-1Î² as the Major HIV-Suppressive Factors Produced by CD8 + T Cells. Science, 270(5243), 1811â1815.

Authors 6

Fiorenza Cocchi (first)
Anthony L. DeVico (additional)
Alfredo Garzino-Demo (additional)
Suresh K. Arya (additional)
Robert C. Gallo (additional)
Paolo Lusso (additional)

References 50 Referenced 2,330

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:35 p.m.)
Indexed	3 days, 2 hours ago (Aug. 26, 2025, 2:29 a.m.)
Issued	29 years, 8 months ago (Dec. 15, 1995)
Published	29 years, 8 months ago (Dec. 15, 1995)
Published Print	29 years, 8 months ago (Dec. 15, 1995)

Funders 0

None

BibTeX

@article{Cocchi_1995, title={Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T Cells}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5243.1811}, DOI={10.1126/science.270.5243.1811}, number={5243}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cocchi, Fiorenza and DeVico, Anthony L. and Garzino-Demo, Alfredo and Arya, Suresh K. and Gallo, Robert C. and Lusso, Paolo}, year={1995}, month=dec, pages={1811–1815} }

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