DOI: 10.1126/science.270.5241.1488. Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest

Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest

10.1126/science.270.5241.1488

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Yeast checkpoint control genes were found to affect processing of DNA damage as well as cell cycle arrest. An assay that measures DNA damage processing in vivo showed that the checkpoint genes RAD17, RAD24 , and MEC3 activated an exonuclease that degrades DNA. The degradation is probably a direct consequence of checkpoint protein function, because RAD17 encodes a putative 3′-5′ DNA exonuclease. Another checkpoint gene, RAD9 , had a different role: It inhibited the degradation by RAD17 , RAD24 , and MEC3 . A model of how processing of DNA damage may be linked to both DNA repair and cell cycle arrest is proposed.

Bibliography

Lydall, D., & Weinert, T. (1995). Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest. Science, 270(5241), 1488â1491.

Authors 2

David Lydall (first)
Ted Weinert (additional)

References 29 Referenced 310

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Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:38 p.m.)
Indexed	2 weeks, 5 days ago (Aug. 7, 2025, 4:23 p.m.)
Issued	29 years, 8 months ago (Dec. 1, 1995)
Published	29 years, 8 months ago (Dec. 1, 1995)
Published Print	29 years, 8 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Lydall_1995, title={Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5241.1488}, DOI={10.1126/science.270.5241.1488}, number={5241}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lydall, David and Weinert, Ted}, year={1995}, month=dec, pages={1488–1491} }

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