DOI: 10.1126/science.270.5237.800. Defective Lymphoid Development in Mice Lacking Jak3

Defective Lymphoid Development in Mice Lacking Jak3

10.1126/science.270.5237.800

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common γ (γ c ) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting. Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in γ c signaling and lymphoid development.

Bibliography

Nosaka, T., van Deursen, J. M. A., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., Doherty, P. C., Grosveld, G. C., & Ihle, J. N. (1995). Defective Lymphoid Development in Mice Lacking Jak3. Science, 270(5237), 800â802.

Authors 9

Tetsuya Nosaka (first)
Jan M. A. van Deursen (additional)
Ralph A. Tripp (additional)
William E. Thierfelder (additional)
Bruce A. Witthuhn (additional)
Anthony P. McMickle (additional)
Peter C. Doherty (additional)
Gerard C. Grosveld (additional)
James N. Ihle (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:14 p.m.)
Indexed	1 week, 5 days ago (Aug. 26, 2025, 2:30 a.m.)
Issued	29 years, 10 months ago (Nov. 3, 1995)
Published	29 years, 10 months ago (Nov. 3, 1995)
Published Print	29 years, 10 months ago (Nov. 3, 1995)

Funders 0

None

BibTeX

@article{Nosaka_1995, title={Defective Lymphoid Development in Mice Lacking Jak3}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5237.800}, DOI={10.1126/science.270.5237.800}, number={5237}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Nosaka, Tetsuya and van Deursen, Jan M. A. and Tripp, Ralph A. and Thierfelder, William E. and Witthuhn, Bruce A. and McMickle, Anthony P. and Doherty, Peter C. and Grosveld, Gerard C. and Ihle, James N.}, year={1995}, month=nov, pages={800–802} }

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