Relaxation of Arterial Smooth Muscle by Calcium Sparks
10.1126/science.270.5236.633
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Local increases in intracellular calcium ion concentration ([Ca 2+ ] i ) resulting from activation of the ryanodine-sensitive calcium-release channel in the sarcoplasmic reticulum (SR) of smooth muscle cause arterial dilation. Ryanodine-sensitive, spontaneous local increases in [Ca 2+ ] i (Ca 2+ sparks) from the SR were observed just under the surface membrane of single smooth muscle cells from myogenic cerebral arteries. Ryanodine and thapsigargin inhibited Ca 2+ sparks and Ca 2+ -dependent potassium (K Ca ) currents, suggesting that Ca 2+ sparks activate K Ca channels. Furthermore, K Ca channels activated by Ca 2+ sparks appeared to hyperpolarize and dilate pressurized myogenic arteries because ryanodine and thapsigargin depolarized and constricted these arteries to an extent similar to that produced by blockers of K Ca channels. Ca 2+ sparks indirectly cause vasodilation through activation of K Ca channels, but have little direct effect on spatially averaged [Ca 2+ ] i , which regulates contraction.

Bibliography

Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J. (1995). Relaxation of Arterial Smooth Muscle by Calcium Sparks. Science, 270(5236), 633–637.

Authors 7
  1. M. T. Nelson (first)
  2. H. Cheng (additional)
  3. M. Rubart (additional)
  4. L. F. Santana (additional)
  5. A. D. Bonev (additional)
  6. H. J. Knot (additional)
  7. W. J. Lederer (additional)
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Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:12 p.m.)
Indexed 13 hours, 25 minutes ago (Aug. 23, 2025, 1:02 a.m.)
Issued 29 years, 9 months ago (Oct. 27, 1995)
Published 29 years, 9 months ago (Oct. 27, 1995)
Published Print 29 years, 9 months ago (Oct. 27, 1995)
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@article{Nelson_1995, title={Relaxation of Arterial Smooth Muscle by Calcium Sparks}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5236.633}, DOI={10.1126/science.270.5236.633}, number={5236}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Nelson, M. T. and Cheng, H. and Rubart, M. and Santana, L. F. and Bonev, A. D. and Knot, H. J. and Lederer, W. J.}, year={1995}, month=oct, pages={633–637} }