Role of Yeast Insulin-Degrading Enzyme Homologs in Propheromone Processing and Bud Site Selection
10.1126/science.270.5235.464
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The Saccharomyces cerevisiae AXL1 gene product Axl1p shares homology with the insulin-degrading enzyme family of endoproteases. Yeast axl1 mutants showed a defect in a-factor pheromone secretion, and a probable site of processing by Axl1p was identified within the a-factor precursor. In addition, Axl1p appears to function as a morphogenetic determinant for axial bud site selection. Amino acid substitutions within the presumptive active site of Axl1p caused defects in propheromone processing but failed to perturb bud site selection. Thus, Axl1p has been shown to participate in the dual regulation of distinct signaling pathways, and a member of the insulinase family has been implicated in propeptide processing.

Bibliography

Adames, N., Blundell, K., Ashby, M. N., & Boone, C. (1995). Role of Yeast Insulin-Degrading Enzyme Homologs in Propheromone Processing and Bud Site Selection. Science, 270(5235), 464–467.

Authors 4
  1. Neil Adames (first)
  2. Kelly Blundell (additional)
  3. Matthew N. Ashby (additional)
  4. Charles Boone (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:17 p.m.)
Indexed 1 month ago (July 24, 2025, 7:53 a.m.)
Issued 29 years, 10 months ago (Oct. 20, 1995)
Published 29 years, 10 months ago (Oct. 20, 1995)
Published Print 29 years, 10 months ago (Oct. 20, 1995)
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@article{Adames_1995, title={Role of Yeast Insulin-Degrading Enzyme Homologs in Propheromone Processing and Bud Site Selection}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5235.464}, DOI={10.1126/science.270.5235.464}, number={5235}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Adames, Neil and Blundell, Kelly and Ashby, Matthew N. and Boone, Charles}, year={1995}, month=oct, pages={464–467} }