Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
10.1126/science.270.5234.286
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-κB) activation in mice and cultured cells. This inhibition is mediated by induction of the IκBα inhibitory protein, which traps activated NF-κB in inactive cytoplasmic complexes. Because NF-κB activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids.

Bibliography

Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995). Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis. Science, 270(5234), 286–290.

Authors 5
  1. Nathalie Auphan (first)
  2. Joseph A. DiDonato (additional)
  3. Caridad Rosette (additional)
  4. Arno Helmberg (additional)
  5. Michael Karin (additional)
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Dates
Type When
Created 18 years, 9 months ago (Oct. 27, 2006, 2:19 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:11 p.m.)
Indexed 2 days, 20 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued 29 years, 10 months ago (Oct. 13, 1995)
Published 29 years, 10 months ago (Oct. 13, 1995)
Published Print 29 years, 10 months ago (Oct. 13, 1995)
Funders 0

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@article{Auphan_1995, title={Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5234.286}, DOI={10.1126/science.270.5234.286}, number={5234}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Auphan, Nathalie and DiDonato, Joseph A. and Rosette, Caridad and Helmberg, Arno and Karin, Michael}, year={1995}, month=oct, pages={286–290} }