Crossref
journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract
Furosemide, a chloride cotransport inhibitor, reversibly blocked synchronized burst discharges in hippocampal slices without reducing the pyramidal cell response to single electrical stimuli. Images of the intrinsic optical signal acquired during these slice experiments indicated that furosemide coincidentally blocked changes in extracellular space. In urethane-anesthetized rats, systemically injected furosemide blocked kainic acid-induced electrical discharges recorded from cortex. These results suggest that (i) neuronal synchronization involved in epileptiform activity can be dissociated from synaptic excitability; (ii) nonsynaptic mechanisms, possibly associated with furosemide-sensitive cell volume regulation, may be critical for synchronization of neuronal activity; and (iii) agents that affect extracellular volume may have clinical utility as antiepileptic drugs.
References
49
Referenced
163
-
AGHAJANIAN A.K., SYNAPSE 31, 331 (1989).
(
10.1002/syn.890030406) / SYNAPSE by AGHAJANIAN A.K. (1989) -
ANDERSON W.W., MAGNESIUM-FREE MEDIUM ACTIVATES SEIZURE-LIKE EVENTS IN THE RAT HIPPOCAMPAL SLICE, BRAIN RESEARCH 398, 215 (1986).
(
10.1016/0006-8993(86)91274-6) / BRAIN RESEARCH / MAGNESIUM-FREE MEDIUM ACTIVATES SEIZURE-LIKE EVENTS IN THE RAT HIPPOCAMPAL SLICE by ANDERSON W.W. (1986) -
BARAN H, EFFECT OF MANNITOL TREATMENT ON BRAIN NEUROTRANSMITTER MARKERS IN KAINIC ACID-INDUCED EPILEPSY, NEUROSCIENCE 21, 679 (1987).
(
10.1016/0306-4522(87)90029-7) / NEUROSCIENCE / EFFECT OF MANNITOL TREATMENT ON BRAIN NEUROTRANSMITTER MARKERS IN KAINIC ACID-INDUCED EPILEPSY by BARAN H (1987) -
BUCKMASTER P.S., A COMPARISON OF RAT HIPPOCAMPAL MOSSY CELLS AND CA3C PYRAMIDAL CELLS, JOURNAL OF NEUROPHYSIOLOGY 70, 1281 (1993).
(
10.1152/jn.1993.70.4.1281) / JOURNAL OF NEUROPHYSIOLOGY / A COMPARISON OF RAT HIPPOCAMPAL MOSSY CELLS AND CA3C PYRAMIDAL CELLS by BUCKMASTER P.S. (1993) -
CARTER C.H., STATUS EPILEPTICUS TREATED BY INTRAVENOUS UREA, EPILEPSIA 3, 198 (1962).
(
10.1111/j.1528-1157.1962.tb05158.x) / EPILEPSIA / STATUS EPILEPTICUS TREATED BY INTRAVENOUS UREA by CARTER C.H. (1962) -
DELVA N.J., POLYDIPSIA IN CHRONIC PSYCHIATRIC-PATIENTS - BODY-WEIGHT AND PLASMA SODIUM, BRITISH JOURNAL OF PSYCHIATRY 152, 242 (1988).
(
10.1192/bjp.152.2.242) / BRITISH JOURNAL OF PSYCHIATRY / POLYDIPSIA IN CHRONIC PSYCHIATRIC-PATIENTS - BODY-WEIGHT AND PLASMA SODIUM by DELVA N.J. (1988) -
DIETZEL I, TRANSIENT CHANGES IN THE SIZE OF THE EXTRACELLULAR-SPACE IN THE SENSORIMOTOR CORTEX OF CATS IN RELATION TO STIMULUS-INDUCED CHANGES IN POTASSIUM CONCENTRATION, EXPERIMENTAL BRAIN RESEARCH 40, 432 (1980).
(
10.1007/BF00236151) / EXPERIMENTAL BRAIN RESEARCH / TRANSIENT CHANGES IN THE SIZE OF THE EXTRACELLULAR-SPACE IN THE SENSORIMOTOR CORTEX OF CATS IN RELATION TO STIMULUS-INDUCED CHANGES IN POTASSIUM CONCENTRATION by DIETZEL I (1980) - DUDEK F.E., ADV NEUROL 44, 593 (1986). / ADV NEUROL by DUDEK F.E. (1986)
-
DUDEK F.E., OSMOLALITY-INDUCED CHANGES IN EXTRACELLULAR VOLUME ALTER EPILEPTIFORM BURSTS INDEPENDENT OF CHEMICAL SYNAPSES IN THE RAT - IMPORTANCE OF NONSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESIS, NEUROSCIENCE LETTERS 120, 267 (1990).
(
10.1016/0304-3940(90)90056-F) / NEUROSCIENCE LETTERS / OSMOLALITY-INDUCED CHANGES IN EXTRACELLULAR VOLUME ALTER EPILEPTIFORM BURSTS INDEPENDENT OF CHEMICAL SYNAPSES IN THE RAT - IMPORTANCE OF NONSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESIS by DUDEK F.E. (1990) -
FERRIER I.N., WATER-INTOXICATION IN PATIENTS WITH PSYCHIATRIC-ILLNESS, BRITISH MEDICAL JOURNAL 291, 1594 (1985).
(
10.1136/bmj.291.6509.1594) / BRITISH MEDICAL JOURNAL / WATER-INTOXICATION IN PATIENTS WITH PSYCHIATRIC-ILLNESS by FERRIER I.N. (1985) -
FORSYTHE W.I., EFFECTIVENESS OF ACETAZOLAMIDE IN THE TREATMENT OF CARBAMAZEPINE-RESISTANT EPILEPSY IN CHILDREN, DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 23, 761 (1981).
(
10.1111/j.1469-8749.1981.tb02064.x) / DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY / EFFECTIVENESS OF ACETAZOLAMIDE IN THE TREATMENT OF CARBAMAZEPINE-RESISTANT EPILEPSY IN CHILDREN by FORSYTHE W.I. (1981) -
GALVAN M, CONVULSANT ACTIONS OF 4-AMINOPYRIDINE ON THE GUINEA-PIG OLFACTORY CORTEX SLICE, BRAIN RESEARCH 241, 75 (1982).
(
10.1016/0006-8993(82)91230-6) / BRAIN RESEARCH / CONVULSANT ACTIONS OF 4-AMINOPYRIDINE ON THE GUINEA-PIG OLFACTORY CORTEX SLICE by GALVAN M (1982) -
GARLAND H.G., Water-pitressin test - In the diagnosis of epilepsy, LANCET 2, 566 (1943).
(
10.1016/S0140-6736(00)87755-7) / LANCET / Water-pitressin test - In the diagnosis of epilepsy by GARLAND H.G. (1943) -
GECK P, ELECTRICALLY SILENT COTRANSPORT OF NA+, K+ AND CL- IN EHRLICH CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 600, 432 (1980).
(
10.1016/0005-2736(80)90446-0) / BIOCHIMICA ET BIOPHYSICA ACTA / ELECTRICALLY SILENT COTRANSPORT OF NA+, K+ AND CL- IN EHRLICH CELLS by GECK P (1980) -
GUILLAUME D, GLIAL CONTRIBUTION TO SEIZURE - CARBONIC-ANHYDRASE ACTIVITY IN EPILEPTIC MAMMALIAN BRAIN, EPILEPSIA 32, 10 (1991).
(
10.1111/j.1528-1157.1991.tb05603.x) / EPILEPSIA / GLIAL CONTRIBUTION TO SEIZURE - CARBONIC-ANHYDRASE ACTIVITY IN EPILEPTIC MAMMALIAN BRAIN by GUILLAUME D (1991) -
HAMMARLUND M.M., DOSE-DEPENDENT PHARMACOKINETICS OF FUROSEMIDE IN THE RAT, BIOPHARMACEUTICS & DRUG DISPOSITION 3, 345 (1982).
(
10.1002/bdd.2510030408) / BIOPHARMACEUTICS & DRUG DISPOSITION / DOSE-DEPENDENT PHARMACOKINETICS OF FUROSEMIDE IN THE RAT by HAMMARLUND M.M. (1982) -
JEFFERYS JGR, NATURE 200, 448 (1982).
(
10.1038/300448a0) / NATURE by JEFFERYS JGR (1982) -
KIMELBERG H.K., ASTROCYTES 3, 129 (1986).
(
10.1016/B978-0-12-250453-2.50009-8) / ASTROCYTES by KIMELBERG H.K. (1986) -
KIMELBERG H.K., FUROSEMIDE-SENSITIVE AND BUMETANIDE-SENSITIVE ION-TRANSPORT AND VOLUME CONTROL IN PRIMARY ASTROCYTE CULTURES FROM RAT-BRAIN, BRAIN RESEARCH 361, 125 (1985).
(
10.1016/0006-8993(85)91282-X) / BRAIN RESEARCH / FUROSEMIDE-SENSITIVE AND BUMETANIDE-SENSITIVE ION-TRANSPORT AND VOLUME CONTROL IN PRIMARY ASTROCYTE CULTURES FROM RAT-BRAIN by KIMELBERG H.K. (1985) - KONNERTH A, EXP BRAIN RES 51, 153 (1984). / EXP BRAIN RES by KONNERTH A (1984)
-
LANGTON P.D., CALCIUM-CHANNEL CURRENTS RECORDED FROM ISOLATED MYOCYTES OF RAT BASILAR ARTERY ARE STRETCH SENSITIVE, JOURNAL OF PHYSIOLOGY-LONDON 471, 1 (1993).
(
10.1113/jphysiol.1993.sp019887) / JOURNAL OF PHYSIOLOGY-LONDON / CALCIUM-CHANNEL CURRENTS RECORDED FROM ISOLATED MYOCYTES OF RAT BASILAR ARTERY ARE STRETCH SENSITIVE by LANGTON P.D. (1993) -
LIPTON P, EFFECTS OF MEMBRANE DEPOLARIZATION ON LIGHT-SCATTERING BY CEREBRAL CORTICAL SLICES, JOURNAL OF PHYSIOLOGY-LONDON 231, 365 (1973).
(
10.1113/jphysiol.1973.sp010238) / JOURNAL OF PHYSIOLOGY-LONDON / EFFECTS OF MEMBRANE DEPOLARIZATION ON LIGHT-SCATTERING BY CEREBRAL CORTICAL SLICES by LIPTON P (1973) -
LOTHMAN E.W., KAINIC ACID-INDUCED LIMBIC SEIZURES - ELECTROPHYSIOLOGIC STUDIES, NEUROLOGY 31, 806 (1981).
(
10.1212/WNL.31.7.806) / NEUROLOGY / KAINIC ACID-INDUCED LIMBIC SEIZURES - ELECTROPHYSIOLOGIC STUDIES by LOTHMAN E.W. (1981) -
MACVICAR B.A., IMAGING OF SYNAPTICALLY EVOKED INTRINSIC OPTICAL SIGNALS IN HIPPOCAMPAL SLICES, JOURNAL OF NEUROSCIENCE 11, 1458 (1991).
(
10.1523/JNEUROSCI.11-05-01458.1991) / JOURNAL OF NEUROSCIENCE / IMAGING OF SYNAPTICALLY EVOKED INTRINSIC OPTICAL SIGNALS IN HIPPOCAMPAL SLICES by MACVICAR B.A. (1991) -
MARTIN D.L., SYNTHESIS AND RELEASE OF NEUROACTIVE SUBSTANCES BY GLIAL-CELLS, GLIA 5, 81 (1992).
(
10.1002/glia.440050202) / GLIA / SYNTHESIS AND RELEASE OF NEUROACTIVE SUBSTANCES BY GLIAL-CELLS by MARTIN D.L. (1992) -
MCBAIN C.J., REGIONAL VARIATION OF EXTRACELLULAR-SPACE IN THE HIPPOCAMPUS, SCIENCE 249, 674 (1990).
(
10.1126/science.2382142) / SCIENCE / REGIONAL VARIATION OF EXTRACELLULAR-SPACE IN THE HIPPOCAMPUS by MCBAIN C.J. (1990) -
MCNAMARA J.O., CELLULAR AND MOLECULAR-BASIS OF EPILEPSY, JOURNAL OF NEUROSCIENCE 14, 3413 (1994).
(
10.1523/JNEUROSCI.14-06-03413.1994) / JOURNAL OF NEUROSCIENCE / CELLULAR AND MOLECULAR-BASIS OF EPILEPSY by MCNAMARA J.O. (1994) -
MEDANI C.R., SEIZURES AND HYPOTHERMIA DUE TO DIETARY WATER-INTOXICATION IN INFANTS, SOUTHERN MEDICAL JOURNAL 80, 421 (1987).
(
10.1097/00007611-198704000-00003) / SOUTHERN MEDICAL JOURNAL / SEIZURES AND HYPOTHERMIA DUE TO DIETARY WATER-INTOXICATION IN INFANTS by MEDANI C.R. (1987) -
MISGELD U, THE ROLE OF CHLORIDE TRANSPORT IN POSTSYNAPTIC INHIBITION OF HIPPOCAMPAL-NEURONS, SCIENCE 232, 1413 (1986).
(
10.1126/science.2424084) / SCIENCE / THE ROLE OF CHLORIDE TRANSPORT IN POSTSYNAPTIC INHIBITION OF HIPPOCAMPAL-NEURONS by MISGELD U (1986) -
PAOLETTI P, MECHANOSENSITIVITY OF NMDA RECEPTORS IN CULTURED MOUSE CENTRAL NEURONS, NEURON 13, 645 (1994).
(
10.1016/0896-6273(94)90032-9) / NEURON / MECHANOSENSITIVITY OF NMDA RECEPTORS IN CULTURED MOUSE CENTRAL NEURONS by PAOLETTI P (1994) -
PARPURA V, GLUTAMATE-MEDIATED ASTROCYTE NEURON SIGNALING, NATURE 369, 744 (1994).
(
10.1038/369744a0) / NATURE / GLUTAMATE-MEDIATED ASTROCYTE NEURON SIGNALING by PARPURA V (1994) -
PEARCE R.A., PHYSIOLOGICAL EVIDENCE FOR 2 DISTINCT GABA(A) RESPONSES IN RAT HIPPOCAMPUS, NEURON 10, 189 (1993).
(
10.1016/0896-6273(93)90310-N) / NEURON / PHYSIOLOGICAL EVIDENCE FOR 2 DISTINCT GABA(A) RESPONSES IN RAT HIPPOCAMPUS by PEARCE R.A. (1993) - READ D.J., J PHARM 146, 154 (1964). / J PHARM by READ D.J. (1964)
-
RICHARDSON T.L., EXTRACELLULAR FIELDS INFLUENCE TRANSMEMBRANE POTENTIALS AND SYNCHRONIZATION OF HIPPOCAMPAL NEURONAL-ACTIVITY, BRAIN RESEARCH 294, 255 (1984).
(
10.1016/0006-8993(84)91037-0) / BRAIN RESEARCH / EXTRACELLULAR FIELDS INFLUENCE TRANSMEMBRANE POTENTIALS AND SYNCHRONIZATION OF HIPPOCAMPAL NEURONAL-ACTIVITY by RICHARDSON T.L. (1984) -
ROPER S.N., OSMOLALITY AND NONSYNAPTIC EPILEPTIFORM BURSTS IN RAT CA1 AND DENTATE GYRUS, ANNALS OF NEUROLOGY 31, 81 (1992).
(
10.1002/ana.410310115) / ANNALS OF NEUROLOGY / OSMOLALITY AND NONSYNAPTIC EPILEPTIFORM BURSTS IN RAT CA1 AND DENTATE GYRUS by ROPER S.N. (1992) -
ROSEN A.S., OSMOTIC EFFECTS UPON EXCITABILITY IN RAT NEOCORTICAL SLICES, NEUROSCIENCE 38, 579 (1990).
(
10.1016/0306-4522(90)90052-6) / NEUROSCIENCE / OSMOTIC EFFECTS UPON EXCITABILITY IN RAT NEOCORTICAL SLICES by ROSEN A.S. (1990) -
SCHWARTZKROIN P.A., CHANGES IN EXCITATORY AND INHIBITORY SYNAPTIC POTENTIALS LEADING TO EPILEPTOGENIC ACTIVITY, BRAIN RESEARCH 183, 61 (1980).
(
10.1016/0006-8993(80)90119-5) / BRAIN RESEARCH / CHANGES IN EXCITATORY AND INHIBITORY SYNAPTIC POTENTIALS LEADING TO EPILEPTOGENIC ACTIVITY by SCHWARTZKROIN P.A. (1980) - SCHWARTZKROIN P.A., TREATMENT EPILEPSY P 83, (1993). / TREATMENT EPILEPSY P by SCHWARTZKROIN P.A. (1993)
-
STASHEFF S.F., INDUCTION OF EPILEPTIFORM ACTIVITY IN HIPPOCAMPAL SLICES BY TRAINS OF ELECTRICAL STIMULI, BRAIN RESEARCH 344, 296 (1985).
(
10.1016/0006-8993(85)90807-8) / BRAIN RESEARCH / INDUCTION OF EPILEPTIFORM ACTIVITY IN HIPPOCAMPAL SLICES BY TRAINS OF ELECTRICAL STIMULI by STASHEFF S.F. (1985) -
TANIMUKAI H, ANTIEPILEPTIC PROPERTY OF INHIBITORS OF CARBONIC ANHYDRASE, BIOCHEMICAL PHARMACOLOGY 14, 961 (1965).
(
10.1016/0006-2952(65)90248-0) / BIOCHEMICAL PHARMACOLOGY / ANTIEPILEPTIC PROPERTY OF INHIBITORS OF CARBONIC ANHYDRASE by TANIMUKAI H (1965) -
TAYLOR C.P., SYNCHRONOUS NEURAL AFTER DISCHARGES IN RAT HIPPOCAMPAL SLICES WITHOUT ACTIVE-CHEMICAL SYNAPSES, SCIENCE 218, 810 (1982).
(
10.1126/science.7134978) / SCIENCE / SYNCHRONOUS NEURAL AFTER DISCHARGES IN RAT HIPPOCAMPAL SLICES WITHOUT ACTIVE-CHEMICAL SYNAPSES by TAYLOR C.P. (1982) -
THOMPSON S.M., RELATIVE CONTRIBUTIONS OF PASSIVE EQUILIBRIUM AND ACTIVE-TRANSPORT TO THE DISTRIBUTION OF CHLORIDE IN MAMMALIAN CORTICAL-NEURONS, JOURNAL OF NEUROPHYSIOLOGY 60, 105 (1988).
(
10.1152/jn.1988.60.1.105) / JOURNAL OF NEUROPHYSIOLOGY / RELATIVE CONTRIBUTIONS OF PASSIVE EQUILIBRIUM AND ACTIVE-TRANSPORT TO THE DISTRIBUTION OF CHLORIDE IN MAMMALIAN CORTICAL-NEURONS by THOMPSON S.M. (1988) -
THOMPSON S.M., ACTIVITY-DEPENDENT DISINHIBITION .2. EFFECTS OF EXTRACELLULAR POTASSIUM, FUROSEMIDE, AND MEMBRANE-POTENTIAL ON ECL- IN HIPPOCAMPAL CA3 NEURONS, JOURNAL OF NEUROPHYSIOLOGY 61, 512 (1989).
(
10.1152/jn.1989.61.3.512) / JOURNAL OF NEUROPHYSIOLOGY / ACTIVITY-DEPENDENT DISINHIBITION .2. EFFECTS OF EXTRACELLULAR POTASSIUM, FUROSEMIDE, AND MEMBRANE-POTENTIAL ON ECL- IN HIPPOCAMPAL CA3 NEURONS by THOMPSON S.M. (1989) -
TRAYNELIS S.F., POTASSIUM-INDUCED SPONTANEOUS ELECTROGRAPHIC SEIZURES IN THE RAT HIPPOCAMPAL SLICE, JOURNAL OF NEUROPHYSIOLOGY 59, 259 (1988).
(
10.1152/jn.1988.59.1.259) / JOURNAL OF NEUROPHYSIOLOGY / POTASSIUM-INDUCED SPONTANEOUS ELECTROGRAPHIC SEIZURES IN THE RAT HIPPOCAMPAL SLICE by TRAYNELIS S.F. (1988) -
VANHARREVELD A, LIGHT-MICROSCOPE AND ELECTRON-MICROSCOPIC CHANGES IN CENTRAL NERVOUS TISSUE AFTER ELECTROPHORETIC INJECTION OF GLUTAMATE, EXPERIMENTAL AND MOLECULAR PATHOLOGY 15, 61 (1971).
(
10.1016/0014-4800(71)90019-0) / EXPERIMENTAL AND MOLECULAR PATHOLOGY / LIGHT-MICROSCOPE AND ELECTRON-MICROSCOPIC CHANGES IN CENTRAL NERVOUS TISSUE AFTER ELECTROPHORETIC INJECTION OF GLUTAMATE by VANHARREVELD A (1971) -
VANHARREVELD A, J NEUROPHYSIOL 30, 911 (1967).
(
10.1152/jn.1967.30.4.911) / J NEUROPHYSIOL by VANHARREVELD A (1967) -
WALZ W, INTENSE FUROSEMIDE-SENSITIVE POTASSIUM ACCUMULATION IN ASTROCYTES IN THE PRESENCE OF PATHOLOGICALLY HIGH EXTRACELLULAR POTASSIUM LEVELS, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 4, 301 (1984).
(
10.1038/jcbfm.1984.42) / JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM / INTENSE FUROSEMIDE-SENSITIVE POTASSIUM ACCUMULATION IN ASTROCYTES IN THE PRESENCE OF PATHOLOGICALLY HIGH EXTRACELLULAR POTASSIUM LEVELS by WALZ W (1984) - WHITE H.S., ADV NEUROL 44, 695 (1986). / ADV NEUROL by WHITE H.S. (1986)
-
ZHANG C.L., PAROXYSMAL EPILEPTIFORM DISCHARGES IN TEMPORAL-LOBE SLICES AFTER PROLONGED EXPOSURE TO LOW MAGNESIUM ARE RESISTANT TO CLINICALLY USED ANTICONVULSANTS, EPILEPSY RESEARCH 20, 105 (1995).
(
10.1016/0920-1211(94)00067-7) / EPILEPSY RESEARCH / PAROXYSMAL EPILEPTIFORM DISCHARGES IN TEMPORAL-LOBE SLICES AFTER PROLONGED EXPOSURE TO LOW MAGNESIUM ARE RESISTANT TO CLINICALLY USED ANTICONVULSANTS by ZHANG C.L. (1995)
Dates
| Type | When |
|---|---|
| Created | 18 years, 10 months ago (Oct. 27, 2006, 2:19 p.m.) |
| Deposited | 1 year, 7 months ago (Jan. 12, 2024, 4:17 p.m.) |
| Indexed | 1 month, 3 weeks ago (July 7, 2025, 1:45 a.m.) |
| Issued | 29 years, 10 months ago (Oct. 6, 1995) |
| Published | 29 years, 10 months ago (Oct. 6, 1995) |
| Published Print | 29 years, 10 months ago (Oct. 6, 1995) |
@article{Hochman_1995, title={Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity}, volume={270}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.270.5233.99}, DOI={10.1126/science.270.5233.99}, number={5233}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hochman, Daryl W. and Baraban, Scott C. and Owens, James W. M. and Schwartzkroin, Philip A.}, year={1995}, month=oct, pages={99–102} }