G 1 Events and Regulation of Cell Proliferation
10.1126/science.2683075
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Cells prepare for S phase during the G 1 phase of the cell cycle. Cell biological methods have provided knowledge of cycle kinetics and of substages of G 1 that are determined by extracellular signals. Through the use of biochemical and molecular biological techniques to study effects of growth factors, oncogenes, and inhibitors, intracellular events during G 1 that lead to DNA synthesis are rapidly being discovered. Many cells in vivo are in a quiescent state (G 0 ), with unduplicated DNA. Cells can be activated to reenter the cycle during G 1 . Similarly, cells in culture can be shifted between G 0 and G 1 . These switches in and out of G 1 are the main determinants of post-embryonic cell proliferation rate and are defectively controlled in cancer cells.

Bibliography

Pardee, A. B. (1989). G 1 Events and Regulation of Cell Proliferation. Science, 246(4930), 603–608.

Authors 1
  1. Arthur B. Pardee (first)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:01 p.m.)
Indexed 2 weeks, 3 days ago (Aug. 7, 2025, 4:34 p.m.)
Issued 35 years, 9 months ago (Nov. 3, 1989)
Published 35 years, 9 months ago (Nov. 3, 1989)
Published Print 35 years, 9 months ago (Nov. 3, 1989)
Funders 0

None

@article{Pardee_1989, title={G 1 Events and Regulation of Cell Proliferation}, volume={246}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2683075}, DOI={10.1126/science.2683075}, number={4930}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pardee, Arthur B.}, year={1989}, month=nov, pages={603–608} }