Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
10.1126/science.2643164
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The discovery that breakdown products of cellular sphingolipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction. Sphingolipids and lysosphingolipids affect significant cellular responses and exhibit antitumor promoter activities in various mammalian cells. These molecules may function as endogenous modulators of cell function and possibly as second messengers.

Bibliography

Hannun, Y. A., & Bell, R. M. (1989). Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation. Science, 243(4890), 500–507.

Authors 2
  1. Yusuf A. Hannun (first)
  2. Robert M. Bell (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:38 p.m.)
Indexed 13 hours, 16 minutes ago (Aug. 27, 2025, 11:53 a.m.)
Issued 36 years, 7 months ago (Jan. 27, 1989)
Published 36 years, 7 months ago (Jan. 27, 1989)
Published Print 36 years, 7 months ago (Jan. 27, 1989)
Funders 0

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@article{Hannun_1989, title={Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation}, volume={243}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2643164}, DOI={10.1126/science.2643164}, number={4890}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hannun, Yusuf A. and Bell, Robert M.}, year={1989}, month=jan, pages={500–507} }