DOI: 10.1126/science.264.5165.1560. Force Detection of Nuclear Magnetic Resonance

Force Detection of Nuclear Magnetic Resonance

10.1126/science.264.5165.1560

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Micromechanical sensing of magnetic force was used to detect nuclear magnetic resonance with exceptional sensitivity and spatial resolution. With a 900 angstrom thick silicon nitride cantilever capable of detecting subfemtonewton forces, a single shot sensitivity of 1.6 × 10 13 protons was achieved for an ammonium nitrate sample mounted on the cantilever. A nearby millimeter-size iron particle produced a 600 tesla per meter magnetic field gradient, resulting in a spatial resolution of 2.6 micrometers in one dimension. These results suggest that magnetic force sensing is a viable approach for enhancing the sensitivity and spatial resolution of nuclear magnetic resonance microimaging.

Bibliography

Rugar, D., ZÃ¼ger, O., Hoen, S., Yannoni, C. S., Vieth, H.-M., & Kendrick, R. D. (1994). Force Detection of Nuclear Magnetic Resonance. Science, 264(5165), 1560â1563.

Authors 6

D. Rugar (first)
O. Züger (additional)
S. Hoen (additional)
C. S. Yannoni (additional)
H.-M. Vieth (additional)
R. D. Kendrick (additional)

References 16 Referenced 238

Abragam, A., The Principles of Nuclear Magnetism: 86 (1961). / The Principles of Nuclear Magnetism (1961)
ALBRECHT, T.R., LOW-TEMPERATURE FORCE MICROSCOPE WITH ALL-FIBER INTERFEROMETER, ULTRAMICROSCOPY 42: 1638 (1992). / ULTRAMICROSCOPY (1992)
Cory, D. G., Annual Reports on NMR Spectroscopy 24: 87 (1992). (10.1016/S0066-4103(08)60197-0) / Annual Reports on NMR Spectroscopy (1992)
DURIG, U, INTERACTION FORCE DETECTION IN SCANNING PROBE MICROSCOPY - METHODS AND APPLICATIONS, JOURNAL OF APPLIED PHYSICS 72: 1778 (1992). (10.1063/1.352348) / JOURNAL OF APPLIED PHYSICS (1992)
Hoen S. Technical Digest of the 1994 Solid-State Sensor and Actuator Workshop (1994).
MERTZ, J, REGULATION OF A MICROCANTILEVER RESPONSE BY FORCE FEEDBACK, APPLIED PHYSICS LETTERS 62: 2344 (1993). (10.1063/1.109413) / APPLIED PHYSICS LETTERS (1993)
RIGGIN, M.T., CATION DIFFUSION STUDY IN NH4NO3 BY PROTON SPIN RELAXATION, JOURNAL OF CHEMICAL PHYSICS 56: 2911 (1972). (10.1063/1.1677625) / JOURNAL OF CHEMICAL PHYSICS (1972)
RUGAR, D, IMPROVED FIBER-OPTIC INTERFEROMETER FOR ATOMIC FORCE MICROSCOPY, APPLIED PHYSICS LETTERS 55: 2588 (1989). (10.1063/1.101987) / APPLIED PHYSICS LETTERS (1989)
RUGAR, D, MECHANICAL DETECTION OF MAGNETIC-RESONANCE, NATURE 360: 563 (1992). (10.1038/360563a0) / NATURE (1992)
SIDLES, J.A., NONINDUCTIVE DETECTION OF SINGLE-PROTON MAGNETIC-RESONANCE, APPLIED PHYSICS LETTERS 58: 2854 (1991). (10.1063/1.104757) / APPLIED PHYSICS LETTERS (1991)
SIDLES J.A. COMMUNICATION.
SIDLES, J.A., FOLDED STERN-GERLACH EXPERIMENT AS A MEANS FOR DETECTING NUCLEAR-MAGNETIC-RESONANCE IN INDIVIDUAL NUCLEI, PHYSICAL REVIEW LETTERS 68: 1124 (1992). (10.1103/PhysRevLett.68.1124) / PHYSICAL REVIEW LETTERS (1992)
SIDLES, J.A., THE THEORY OF OSCILLATOR-COUPLED MAGNETIC-RESONANCE WITH POTENTIAL APPLICATIONS TO MOLECULAR IMAGING, REVIEW OF SCIENTIFIC INSTRUMENTS 63: 3881 (1992). (10.1063/1.1143837) / REVIEW OF SCIENTIFIC INSTRUMENTS (1992)
Slichter, C. P., Principles of Magnetic Resonance: 24 (1990). / Principles of Magnetic Resonance (1990)
VIETH H.M. unpublished data.
ZUGER, O, 1ST IMAGES FROM A MAGNETIC-RESONANCE FORCE MICROSCOPE, APPLIED PHYSICS LETTERS 63: 2496 (1993). (10.1063/1.110460) / APPLIED PHYSICS LETTERS (1993)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 6:45 p.m.)
Indexed	1 month, 2 weeks ago (July 4, 2025, 8:46 a.m.)
Issued	31 years, 2 months ago (June 10, 1994)
Published	31 years, 2 months ago (June 10, 1994)
Published Print	31 years, 2 months ago (June 10, 1994)

Funders 0

None

BibTeX

@article{Rugar_1994, title={Force Detection of Nuclear Magnetic Resonance}, volume={264}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.264.5165.1560}, DOI={10.1126/science.264.5165.1560}, number={5165}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rugar, D. and Züger, O. and Hoen, S. and Yannoni, C. S. and Vieth, H.-M. and Kendrick, R. D.}, year={1994}, month=jun, pages={1560–1563} }

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