Lipid Tubules: A Paradigm for Molecularly Engineered Structures
10.1126/science.262.5140.1669
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The use of molecular self-assembly to fabricate microstructures suitable for advanced material development is described. Templating techniques that transform biomolecular self-assemblies into rugged and stable nano- and microstructures are described. By using a lipid-based microcylinder (tubule) as a paradigm, the path followed from research and development to emerging technological applications is detailed. This process includes modification of the lipid molecular structure, the formation and subsequent characterization of cylindrical microstructures, the use of these structures as templates for metallization, and the characterization and assessment of these hollow metal microcylinders for several potential applications.

Bibliography

Schnur, J. M. (1993). Lipid Tubules: A Paradigm for Molecularly Engineered Structures. Science, 262(5140), 1669–1676.

Authors 1
  1. Joel M. Schnur (first)
References 86 Referenced 666
  1. 10.1126/science.254.5036.1300
  2. Singh A. U.S. Patent 4 867 917 (1989).
  3. Schnur J. M. U.S. Patent 4 877 501 (1989). (10.1016/0375-9474(89)90167-X)
  4. Schnur J. M. U.S. Patent 4 911 981 (1990).
  5. AHL, P.L., INSERTION OF BACTERIORHODOPSIN INTO POLYMERIZED DIACETYLENIC PHOSPHATIDYLCHOLINE BILAYERS, BIOCHIMICA ET BIOPHYSICA ACTA 1028: 141 (1990). (10.1016/0005-2736(90)90148-H) / BIOCHIMICA ET BIOPHYSICA ACTA (1990)
  6. BEHROOZI, F, INTERACTION OF METALLIZED TUBULES WITH ELECTROMAGNETIC-RADIATION, JOURNAL OF APPLIED PHYSICS 68: 3688 (1990). (10.1063/1.346332) / JOURNAL OF APPLIED PHYSICS (1990)
  7. Bohren C. F. Absorption and Scattering of Light by Small Particles (1983).
  8. BRANDOW, S.L., MODIFICATION OF SUPPORTED LIPID-MEMBRANES BY ATOMIC FORCE MICROSCOPY, BIOPHYSICAL JOURNAL 64: 898 (1993). (10.1016/S0006-3495(93)81450-4) / BIOPHYSICAL JOURNAL (1993)
  9. BRENNER, A, P AM ELECTROPLAT SOC 33: 23 (1946). / P AM ELECTROPLAT SOC (1946)
  10. BURKE, T.G., DIFFERENTIAL SCANNING CALORIMETRIC STUDY OF THE THERMOTROPIC PHASE-BEHAVIOR OF A POLYMERIZABLE, TUBULE-FORMING LIPID, CHEMISTRY AND PHYSICS OF LIPIDS 48: 215 (1988). (10.1016/0009-3084(88)90092-8) / CHEMISTRY AND PHYSICS OF LIPIDS (1988)
  11. CAFFREY, M, DIACETYLENIC LIPID MICROSTRUCTURES - STRUCTURAL CHARACTERIZATION BY X-RAY-DIFFRACTION AND COMPARISON WITH THE SATURATED PHOSPHATIDYLCHOLINE ANALOG, BIOCHEMISTRY 30: 2134 (1991). (10.1021/bi00222a018) / BIOCHEMISTRY (1991)
  12. CALVERT, J. M., SOLID STATE TECHNOLOGY 34: 77 (1991). / SOLID STATE TECHNOLOGY (1991)
  13. CALVERT, J.M., DEEP UV PHOTOCHEMISTRY AND PATTERNING OF SELF-ASSEMBLED MONOLAYER FILMS, THIN SOLID FILMS 210: 359 (1992). / THIN SOLID FILMS (1992)
  14. CHAPPELL, J.S., A MODEL FOR CRYSTALLINE ORDER WITHIN HELICAL AND TUBULAR STRUCTURES OF CHIRAL BILAYERS, CHEMISTRY AND PHYSICS OF LIPIDS 58: 253 (1991). (10.1016/0009-3084(91)90100-P) / CHEMISTRY AND PHYSICS OF LIPIDS (1991)
  15. Chow, C. M., Materials Science and Engineering A 158: 1 (1992). (10.1016/0921-5093(92)90128-N) / Materials Science and Engineering A (1992)
  16. Chung, D. S., Proc. Nati. Acad. Sci. U.S.A. 90:11341 (1993). (10.1073/pnas.90.23.11341) / Proc. Nati. Acad. Sci. U.S.A. (1993)
  17. DEGENNES, P.G., ELECTROSTATIC BUCKLING OF CHIRAL LIPID BILAYERS, COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II 304: 259 (1987). / COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II (1987)
  18. FRANKEL, D.A., SUPRAMOLECULAR ASSEMBLIES OF DIACETYLENIC ALDONAMIDES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 113: 7436 (1991). (10.1021/ja00019a059) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1991)
  19. FUHRHOP, J.H., LIPID BILAYER FIBERS FROM DIASTEREOMERIC AND ENANTIOMERIC N-OCTYLALDONAMIDES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 110: 2861 (1988). (10.1021/ja00217a028) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1988)
  20. GEORGER, J.H., HELICAL AND TUBULAR MICROSTRUCTURES FORMED BY POLYMERIZABLE PHOSPHATIDYLCHOLINES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 109: 6169 (1987). (10.1021/ja00254a042) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1987)
  21. HELFRICH, W, INTRINSIC BENDING FORCE IN ANISOTROPIC MEMBRANES MADE OF CHIRAL MOLECULES, PHYSICAL REVIEW A 38: 3065 (1988). (10.1103/PhysRevA.38.3065) / PHYSICAL REVIEW A (1988)
  22. IHARA, H, NIPPON KAGAKU KAISHI 3: 543 (1987). / NIPPON KAGAKU KAISHI (1987)
  23. IHARA, H, EXCEPTIONAL MORPHOLOGIES AND METAMORPHOSIS OF BILAYER-MEMBRANES FORMED FROM AMPHIPHILES WITH POLY(L-ASPARTIC ACID)-HEAD GROUPS, POLYMER COMMUNICATIONS 27: 282 (1986). / POLYMER COMMUNICATIONS (1986)
  24. Israelachvili J. N. Intermolecular and Surface Forces 2 (1992).
  25. JOHNSTON, D.S., PHOSPHOLIPID POLYMERS - SYNTHESIS AND SPECTRAL CHARACTERISTICS, BIOCHIMICA ET BIOPHYSICA ACTA 602: 57 (1980). (10.1016/0005-2736(80)90289-8) / BIOCHIMICA ET BIOPHYSICA ACTA (1980)
  26. Johnston, D. S., Liposome Technology 1: 123 (1984). / Liposome Technology (1984)
  27. KIRKPATRICK, D.A., DEMONSTRATION OF VACUUM FIELD-EMISSION FROM A SELF-ASSEMBLING BIOMOLECULAR MICROSTRUCTURE COMPOSITE, APPLIED PHYSICS LETTERS 60: 1556 (1992). (10.1063/1.107249) / APPLIED PHYSICS LETTERS (1992)
  28. KIRKPATRICK, D.A., A MILLIMETER AND SUBMILLIMETER WAVELENGTH FREE-ELECTRON LASER, PHYSICS OF FLUIDS B-PLASMA PHYSICS 1: 1511 (1989). (10.1063/1.858927) / PHYSICS OF FLUIDS B-PLASMA PHYSICS (1989)
  29. KREBS, J.J., MAGNETIC-PROPERTIES OF PERMALLOY-COATED ORGANIC TUBULES, JOURNAL OF APPLIED PHYSICS 70: 6404 (1991). (10.1063/1.349936) / JOURNAL OF APPLIED PHYSICS (1991)
  30. 10.1038/359710a0
  31. KUNITAKE, T, SYNTHETIC BILAYER-MEMBRANES - MOLECULAR DESIGN, SELF-ORGANIZATION, AND APPLICATION, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 31: 709 (1992). (10.1002/anie.199207091) / ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH (1992)
  32. KUNITAKE, T, CHEMISTRY LETTERS: 1347 (1980). / CHEMISTRY LETTERS (1980)
  33. KUNITAKE, T, UNIQUE PROPERTIES OF CHROMOPHORE-CONTAINING BILAYER AGGREGATES - ENHANCED CHIRALITY AND PHOTOCHEMICALLY INDUCED MORPHOLOGICAL CHANGE, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 102: 6642 (1980). (10.1021/ja00541a081) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1980)
  34. KUNITAKE, T, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS: 655 (1986). / JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS (1986)
  35. Kunitake, T., Supramolecular Assemblies: New Developments in Biofunctional Chemistry: 17 (1990). / Supramolecular Assemblies: New Developments in Biofunctional Chemistry (1990)
  36. Lackner, A., Liquid Crystals 14:351 (1993). (10.1080/02678299308027650) / Liquid Crystals (1993)
  37. Lackner A. paper presented at the 14th International Liquid Crystal Conference Pisa Italy June (1992).
  38. Lando, J, Chemistry of Materials 2: 594 (1990). (10.1021/cm00011a024) / Chemistry of Materials (1990)
  39. LUBENSKY, T.C., ORIENTATIONAL ORDER AND VESICLE SHAPE, JOURNAL DE PHYSIQUE II 2: 371 (1992). (10.1051/jp2:1992133) / JOURNAL DE PHYSIQUE II (1992)
  40. MARKOWITZ, M, SELF-ASSEMBLING PROPERTIES OF 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOHYDROXYETHANOL - A HEADGROUP-MODIFIED DIACETYLENIC PHOSPHOLIPID, LANGMUIR 7: 16 (1991). (10.1021/la00049a005) / LANGMUIR (1991)
  41. MARKOWITZ, M. A., CHEMISTRY AND PHYSICS OF LIPIDS 62: 193 (1992). (10.1016/0009-3084(92)90097-9) / CHEMISTRY AND PHYSICS OF LIPIDS (1992)
  42. Markowitz, M. A., Synthetic Microstructures in Biology: 29 (1992). / Synthetic Microstructures in Biology (1992)
  43. MARKOWITZ, M, PALLADIUM ION ASSISTED FORMATION AND METALLIZATION OF LIPID TUBULES, THIN SOLID FILMS 224: 242 (1993). (10.1016/0040-6090(93)90440-Z) / THIN SOLID FILMS (1993)
  44. NAKASHIMA, N, OPTICAL MICROSCOPIC STUDY OF HELICAL SUPERSTRUCTURES OF CHIRAL BILAYER-MEMBRANES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 107: 509 (1985). (10.1021/ja00288a043) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1985)
  45. NELSON, P, PHYSICAL REVIEW LETTERS 69: 3409 (1992). (10.1103/PhysRevLett.69.3409) / PHYSICAL REVIEW LETTERS (1992)
  46. OUYANG, Z.C., PHYS REV A 43: 6826 (1991). (10.1103/PhysRevA.43.6826) / PHYS REV A (1991)
  47. PAZIRANDEH, M, BIOMIMETICS 1: 41 (1992). / BIOMIMETICS (1992)
  48. PRICE, R.R., BIOFOULING 6: 207 (1992). (10.1080/08927019209386223) / BIOFOULING (1992)
  49. Price, R., Journal of Microencapsulation 10:215 (1993). (10.3109/02652049309104387) / Journal of Microencapsulation (1993)
  50. PRICE, R, CONTROLLED RELEASE FROM CYLINDRICAL MICROSTRUCTURES, JOURNAL OF MICROENCAPSULATION 8: 301 (1991). (10.3109/02652049109069556) / JOURNAL OF MICROENCAPSULATION (1991)
  51. PRINZ, G.A., HYBRID FERROMAGNETIC-SEMICONDUCTOR STRUCTURES, SCIENCE 250: 1092 (1990). (10.1126/science.250.4984.1092) / SCIENCE (1990)
  52. RATNA, B.R., EFFECT OF ALCOHOL CHAIN-LENGTH ON TUBULE FORMATION IN 1,2-BIS(10,12-TRICOSADIYNOYL)-SN-GLYCERO-3-PHOSPHOCHOLINE, CHEMISTRY AND PHYSICS OF LIPIDS 63: 47 (1992). (10.1016/0009-3084(92)90021-G) / CHEMISTRY AND PHYSICS OF LIPIDS (1992)
  53. RHODES, D.G., STRUCTURE OF POLYMERIZABLE LIPID BILAYERS .1. 1,2-BIS(10,12-TRICOSADIYNOYL)-SN-GLYCERO-3-PHOSPHOCHOLINE, A TUBULE-FORMING PHOSPHATIDYLCHOLINE, CHEMISTRY AND PHYSICS OF LIPIDS 49: 39 (1988). (10.1016/0009-3084(88)90062-X) / CHEMISTRY AND PHYSICS OF LIPIDS (1988)
  54. RINGSDORF, H, MOLECULAR ARCHITECTURE AND FUNCTION OF POLYMERIC ORIENTED SYSTEMS - MODELS FOR THE STUDY OF ORGANIZATION, SURFACE RECOGNITION, AND DYNAMICS OF BIOMEMBRANES, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 27: 113 (1988). (10.1002/anie.198801131) / ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH (1988)
  55. ROBERSON, C. W., PROCEEDINGS OF SPIE 453: 320 (1983). / PROCEEDINGS OF SPIE (1983)
  56. RUDOLPH, A.S., PHASE CHARACTERISTICS OF POSITIONAL ISOMERS OF 1,2-DI(HEPTACOSADIYNOYL)-SN-GLYCERO-3-PHOSPHOCHOLINE - TUBULE-FORMING PHOSPHATIDYLCHOLINES, BIOCHIMICA ET BIOPHYSICA ACTA 943: 454 (1988). (10.1016/0005-2736(88)90377-X) / BIOCHIMICA ET BIOPHYSICA ACTA (1988)
  57. Rudolph, A. S., Biotechnological Applications of Lipid Microstructures: 320 (1988). / Biotechnological Applications of Lipid Microstructures (1988)
  58. RUDOLPH, A.S., WATER-FREE SELF-ASSEMBLY OF PHOSPHOLIPID TUBULES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 111: 8516 (1989). (10.1021/ja00204a033) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1989)
  59. RUDOLPH, A.S., SELF-ASSEMBLING PHOSPHOLIPID FILAMENTS, NATURE 352: 52 (1991). (10.1038/352052a0) / NATURE (1991)
  60. SAITO, R, MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY 19: 185 (1993). (10.1016/0921-5107(93)90186-Q) / MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY (1993)
  61. Schnur, J. M., Journal of Controlled Release 28:3 (1994). (10.1016/0168-3659(94)90149-X) / Journal of Controlled Release (1994)
  62. SCHNUR, J.M., LIPID-BASED TUBULE MICROSTRUCTURES, THIN SOLID FILMS 152: 181 (1987). (10.1016/0040-6090(87)90416-0) / THIN SOLID FILMS (1987)
  63. Schnur J. paper presented at the Sixth International Symposium on Recent Advances in Drug Delivery Systems Salt Lake City UT 22 to 25 February (1993).
  64. SCHOEN, P. E., JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS 23: 2203 (1985). (10.1002/pol.1985.180231015) / JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS (1985)
  65. Schoen, P. E., Polydiacetylenes: Synthesis, Structure, and Electronic Properties: 223 (1985). / Polydiacetylenes: Synthesis, Structure, and Electronic Properties (1985)
  66. SELINGER J COMMUNICATION.
  67. SELINGER, J. V., BULLETIN OF THE AMERICAN PHYSICAL SOCIETY 38: 404 (1993). / BULLETIN OF THE AMERICAN PHYSICAL SOCIETY (1993)
  68. Selinger, J. V., Physical Review Letters 71:4091 (1993). (10.1103/PhysRevLett.71.4091) / Physical Review Letters (1993)
  69. Shafik, S. E., Biopolymeric Controlled Release Systems 2: 139 (1984). / Biopolymeric Controlled Release Systems (1984)
  70. Shashidhar R. Self-Assembled Structures and Materials. (1994).
  71. SHEFFIELD, R.L., THE LOS-ALAMOS PHOTOINJECTOR PROGRAM, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 272: 222 (1988). (10.1016/0168-9002(88)90227-6) / NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT (1988)
  72. Sheridan J. S. Naval Research Laboratory Memorandum Report 5975 (1988).
  73. Shipley C. R. Electroless Plating: Fundamentals & Applications (1990).
  74. SHIPLEY, C.R., HISTORICAL HIGHLIGHTS OF ELECTROLESS PLATING, PLATING AND SURFACE FINISHING 71: 92 (1984). / PLATING AND SURFACE FINISHING (1984)
  75. SINGH, A, LATERAL PHASE-SEPARATION BASED ON CHIRALITY IN A POLYMERIZABLE LIPID AND ITS INFLUENCE ON FORMATION OF TUBULAR MICROSTRUCTURES, CHEMISTRY AND PHYSICS OF LIPIDS 47: 135 (1988). (10.1016/0009-3084(88)90083-7) / CHEMISTRY AND PHYSICS OF LIPIDS (1988)
  76. SINGH, A, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS: 1222 (1988). / JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS (1988)
  77. Singh, A., Phospholipid Handbook: 233 (1993). / Phospholipid Handbook (1993)
  78. SINGH, A, POLYMERIC MATERIALS: SCIENCE AND ENGINEERING 61: 675 (1989). / POLYMERIC MATERIALS: SCIENCE AND ENGINEERING (1989)
  79. SINGH, A, POLYM PREPR-ACS 26: 184 (1985). / POLYM PREPR-ACS (1985)
  80. SINGH, A, SYNTHETIC COMMUNICATIONS 16 847 (1986). (10.1080/00397918608059667) / SYNTHETIC COMMUNICATIONS (1986)
  81. STOCKTON, W, ARTIFICIAL DIELECTRIC-PROPERTIES OF MICROSCOPIC METALLIZED FILAMENTS IN COMPOSITES, JOURNAL OF APPLIED PHYSICS 70: 4679 (1991). (10.1063/1.349059) / JOURNAL OF APPLIED PHYSICS (1991)
  82. 10.1126/science.254.5036.1319
  83. THOMAS, B, MATERIALS RESEARCH SOCIETY SYMPOSIA PROCEEDINGS 248: 83 (1992). / MATERIALS RESEARCH SOCIETY SYMPOSIA PROCEEDINGS (1992)
  84. 10.1126/science.1962191
  85. YAGER, P, FORMATION OF TUBULES BY A POLYMERIZABLE SURFACTANT, MOLECULAR CRYSTALS AND LIQUID CRYSTALS 106: 371 (1984). (10.1080/00268948408071454) / MOLECULAR CRYSTALS AND LIQUID CRYSTALS (1984)
  86. YAMADA, K, CHEMISTRY LETTERS: 1713 (1984). / CHEMISTRY LETTERS (1984)
Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 6:19 p.m.)
Indexed 1 week, 2 days ago (Aug. 20, 2025, 8:25 a.m.)
Issued 31 years, 8 months ago (Dec. 10, 1993)
Published 31 years, 8 months ago (Dec. 10, 1993)
Published Print 31 years, 8 months ago (Dec. 10, 1993)
Funders 0

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@article{Schnur_1993, title={Lipid Tubules: A Paradigm for Molecularly Engineered Structures}, volume={262}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.262.5140.1669}, DOI={10.1126/science.262.5140.1669}, number={5140}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schnur, Joel M.}, year={1993}, month=dec, pages={1669–1676} }