DOI: 10.1126/science.2580349. Homology of β-Lactoglobulin, Serum Retinol-Binding Protein, and Protein HC

Homology of β-Lactoglobulin, Serum Retinol-Binding Protein, and Protein HC

10.1126/science.2580349

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The milk protein β-lactoglobulin has been extensively studied but its function has not been identified. A clue regarding the function of a protein can be obtained by discovering a genetic relationship with a protein of known function through comparisons of amino acid sequence. Such comparisons revealed that β-lactoglobulin is similar to human serum retinol-binding protein and to another human protein of unknown function known as complex-forming glycoprotein heterogeneous in charge (protein HC). β-Lactoglobulins from several species have been found to bind retinol, while the absorption and fluorescence properties reported for the unidentified heterogeneous prosthetic group of protein HC are retinoid-like. The role of serum retinol-binding protein in vitamin A transport in the circulation suggests that the other two homologous proteins may function in the binding and transport of retinoids; β-lactoglobulin may facilitate the absorption of vitamin A from milk and protein HC may mediate the excretion of retinol-derived metabolites.

Bibliography

Pervaiz, S., & Brew, K. (1985). Homology of Î²-Lactoglobulin, Serum Retinol-Binding Protein, and Protein HC. Science, 228(4697), 335â337.

Authors 2

Syed Pervaiz (first)
Keith Brew (additional)

References 27 Referenced 216

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BELL, K, PORCINE BETA-LACTOGLOBULIN-A AND BETA-LACTOGLOBULIN-C - OCCURRENCE, ISOLATION AND CHEMICAL-PROPERTIES, MOLECULAR AND CELLULAR BIOCHEMISTRY 35: 103 (1981). (10.1007/BF02354824) / MOLECULAR AND CELLULAR BIOCHEMISTRY (1981)
CREAMER, L.K., SECONDARY STRUCTURE OF BOVINE BETA-LACTOGLOBULIN-B, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 227: 98 (1983). (10.1016/0003-9861(83)90351-X) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1983)
10.1126/science.7280687
EKSTROM, B, URINARY AND PLASMA ALPHA-1-GLYCOPROTEIN OF LOW-MOLECULAR WEIGHT - ISOLATION AND SOME PROPERTIES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 65: 1427 (1975). (10.1016/S0006-291X(75)80388-3) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1975)
EKSTROM, B, HUMAN ALPHA1-MICROGLOBULIN - PURIFICATION PROCEDURE, CHEMICAL AND PHYSICOCHEMICAL PROPERTIES, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 8048 (1977). (10.1016/S0021-9258(17)40934-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
FEIGELSON P COMMUNICATION.
Frangione, B., FEBS Letters 70: 239 (1976). (10.1016/0014-5793(76)80765-X) / FEBS Letters (1976)
FUGATE, R.D., SPECTROSCOPIC CHARACTERIZATION OF BETA-LACTOGLOBULIN-RETINOL COMPLEX, BIOCHIMICA ET BIOPHYSICA ACTA 625: 28 (1980). (10.1016/0005-2795(80)90105-1) / BIOCHIMICA ET BIOPHYSICA ACTA (1980)
FUTTERMAN, S, ENHANCEMENT OF FLUORESCENCE AND DECREASED SUSCEPTIBILITY TO ENZYMATIC OXIDATION OF RETINOL COMPLEXED WITH BOVINE SERUM-ALBUMIN, BETA-LACTOGLOBULIN, AND RETINOL-BINDING PROTEIN OF HUMAN PLASMA, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 5168 (1972). (10.1016/S0021-9258(19)44953-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1972)
Goodman, D. S., The Retinoids 2: 47 (1984). / The Retinoids (1984)
GREEN, D.W., JOURNAL OF MOLECULAR BIOLOGY 131: 375 (1979). (10.1016/0022-2836(79)90082-2) / JOURNAL OF MOLECULAR BIOLOGY (1979)
HEMLEY, R, ABSORPTION-SPECTRA FOR THE COMPLEXES FORMED FROM VITAMIN-A AND BETA-LACTOGLOBULIN, BIOPHYSICAL JOURNAL 28: 447 (1979). (10.1016/S0006-3495(79)85192-9) / BIOPHYSICAL JOURNAL (1979)
KESSLER, E, WHEY PROTEINS OF PIGS MILK ISOLATION AND CHARACTERIZATION OF A BETA-LACTOGLOBULIN, BIOCHIMICA ET BIOPHYSICA ACTA 200: 449 (1970). (10.1016/0005-2795(70)90101-7) / BIOCHIMICA ET BIOPHYSICA ACTA (1970)
LOPEZ, C, THE COMPLETE AMINO-ACID-SEQUENCE OF HUMAN COMPLEX-FORMING GLYCOPROTEIN HETEROGENEOUS IN CHARGE (PROTEIN HC), BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 103: 919 (1981). (10.1016/0006-291X(81)90898-6) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1981)
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NEWCOMER, M.E., THE 3-DIMENSIONAL STRUCTURE OF RETINOL-BINDING PROTEIN, EMBO JOURNAL 3: 1451 (1984). (10.1002/j.1460-2075.1984.tb01995.x) / EMBO JOURNAL (1984)
PERVAIZ S unpublished data.
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RASK, L, STRUCTURAL AND FUNCTIONAL-STUDIES OF VITAMIN-A-BINDING PROTEINS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 359: 79 (1981). (10.1111/j.1749-6632.1981.tb12739.x) / ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1981)
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SHEWALE, J.G., EVOLUTION OF ALPHA-LACTALBUMINS THE COMPLETE AMINO-ACID-SEQUENCE OF THE ALPHA-LACTALBUMIN FROM A MARSUPIAL (MACROPUS-RUFOGRISEUS) AND CORRECTIONS TO REGIONS OF SEQUENCE IN BOVINE AND GOAT ALPHA-LACTALBUMINS, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 4947 (1984). (10.1016/S0021-9258(17)42938-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1984)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 6:16 p.m.)
Indexed	2 months, 3 weeks ago (June 3, 2025, 12:26 a.m.)
Issued	40 years, 4 months ago (April 19, 1985)
Published	40 years, 4 months ago (April 19, 1985)
Published Print	40 years, 4 months ago (April 19, 1985)

Funders 0

None

BibTeX

@article{Pervaiz_1985, title={Homology of β-Lactoglobulin, Serum Retinol-Binding Protein, and Protein HC}, volume={228}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2580349}, DOI={10.1126/science.2580349}, number={4697}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pervaiz, Syed and Brew, Keith}, year={1985}, month=apr, pages={335–337} }

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