Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy
10.1126/science.257.5073.1134
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.

Bibliography

Kang, S.-M., Beverly, B., Tran, A.-C., Brorson, K., Schwartz, R. H., & Lenardot, M. J. (1992). Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy. Science, 257(5073), 1134–1138.

Authors 6
  1. Sang-Mo Kang (first)
  2. Bart Beverly (additional)
  3. Annie-Chen Tran (additional)
  4. Kurt Brorson (additional)
  5. Ronald H. Schwartz (additional)
  6. Michael J. Lenardot (additional)
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Dates
Type When
Created 18 years, 11 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 6:57 p.m.)
Indexed 1 month ago (July 30, 2025, 8:25 p.m.)
Issued 33 years ago (Aug. 21, 1992)
Published 33 years ago (Aug. 21, 1992)
Published Print 33 years ago (Aug. 21, 1992)
Funders 0

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@article{Kang_1992, title={Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy}, volume={257}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.257.5073.1134}, DOI={10.1126/science.257.5073.1134}, number={5073}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kang, Sang-Mo and Beverly, Bart and Tran, Annie-Chen and Brorson, Kurt and Schwartz, Ronald H. and Lenardot, Michael J.}, year={1992}, month=aug, pages={1134–1138} }