DOI: 10.1126/science.256.5060.1180. Reproducible Imaging and Dissection of Plasmid DNA Under Liquid with the Atomic Force Microscope

Reproducible Imaging and Dissection of Plasmid DNA Under Liquid with the Atomic Force Microscope

10.1126/science.256.5060.1180

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Reproducible images of uncoated DNA in the atomic force microscope (AFM) have been obtained by imaging plasmid DNA on mica in n -propanol. Specially sharpened AFM tips give images with reproducible features several nanometers in size along the DNA. Plasmids can be dissected in propanol by increasing the force applied by the AFM tip at selected locations.

Bibliography

Hansma, H. G., Vesenka, J., Siegerist, C., Kelderman, G., Morrett, H., Sinsheimer, R. L., Elings, V., Bustamante, C., & Hansma, P. K. (1992). Reproducible Imaging and Dissection of Plasmid DNA Under Liquid with the Atomic Force Microscope. Science, 256(5060), 1180â1184.

Authors 9

H. G. Hansma (first)
J. Vesenka (additional)
C. Siegerist (additional)
G. Kelderman (additional)
H. Morrett (additional)
R. L. Sinsheimer (additional)
V. Elings (additional)
C. Bustamante (additional)
P. K. Hansma (additional)

References 33 Referenced 409

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:05 p.m.)
Indexed	0 minutes ago (Aug. 30, 2025, 12:51 p.m.)
Issued	33 years, 3 months ago (May 22, 1992)
Published	33 years, 3 months ago (May 22, 1992)
Published Print	33 years, 3 months ago (May 22, 1992)

Funders 0

None

BibTeX

@article{Hansma_1992, title={Reproducible Imaging and Dissection of Plasmid DNA Under Liquid with the Atomic Force Microscope}, volume={256}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.256.5060.1180}, DOI={10.1126/science.256.5060.1180}, number={5060}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hansma, H. G. and Vesenka, J. and Siegerist, C. and Kelderman, G. and Morrett, H. and Sinsheimer, R. L. and Elings, V. and Bustamante, C. and Hansma, P. K.}, year={1992}, month=may, pages={1180–1184} }

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