DOI: 10.1126/science.256.5055.370. Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

10.1126/science.256.5055.370

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBPβ, a member of the bZip family of transcription factors. In pituitary cells C/EBPβ was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin— dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBPβ appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBPβ.

Bibliography

Wegner, M., Cao, Z., & Rosenfeld, M. G. (1992). Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPÎ². Science, 256(5055), 370â373.

Authors 3

Michael Wegner (first)
Zhaodan Cao (additional)
Michael G. Rosenfeld (additional)

References 44 Referenced 287

AKIRA, S, A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY, EMBO JOURNAL 9: 1897 (1990). (10.1002/j.1460-2075.1990.tb08316.x) / EMBO JOURNAL (1990)
ANGEL, P, ONCOGENE JUN ENCODES A SEQUENCE-SPECIFIC TRANS-ACTIVATOR SIMILAR TO AP-1, NATURE 332: 166 (1988). (10.1038/332166a0) / NATURE (1988)
BENNETT, M.K., DEDUCED PRIMARY STRUCTURE OF THE BETA-SUBUNIT OF BRAIN TYPE-II CA-2+/CALMODULIN-DEPENDENT PROTEIN-KINASE DETERMINED BY MOLECULAR-CLONING, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 1794 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
BIRKENMEIER, E.H., TISSUE-SPECIFIC EXPRESSION, DEVELOPMENTAL REGULATION, AND GENETIC-MAPPING OF THE GENE ENCODING CCAAT ENHANCER BINDING-PROTEIN, GENES & DEVELOPMENT 3: 1146 (1989). (10.1101/gad.3.8.1146) / GENES & DEVELOPMENT (1989)
10.1126/science.2825349
BULLEIT, R.F., CONSERVED AND VARIABLE REGIONS IN THE SUBUNITS OF BRAIN TYPE-II CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE, NEURON 1: 63 (1988). (10.1016/0896-6273(88)90210-3) / NEURON (1988)
BURGIN, K.E., INSITU HYBRIDIZATION HISTOCHEMISTRY OF CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE IN DEVELOPING RAT-BRAIN, JOURNAL OF NEUROSCIENCE 10: 1788 (1990). (10.1523/JNEUROSCI.10-06-01788.1990) / JOURNAL OF NEUROSCIENCE (1990)
CAO, Z.D., REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS, GENES & DEVELOPMENT 5: 1538 (1991). (10.1101/gad.5.9.1538) / GENES & DEVELOPMENT (1991)
CAPPS, G.G., ENDOCYTOSIS OF THE CLASS-I MAJOR HISTOCOMPATIBILITY ANTIGEN VIA A PHORBOL-MYRISTATE ACETATE-INDUCIBLE PATHWAY IS A CELL-SPECIFIC PHENOMENON AND REQUIRES THE CYTOPLASMIC DOMAIN, JOURNAL OF CELL BIOLOGY 108: 1317 (1989). (10.1083/jcb.108.4.1317) / JOURNAL OF CELL BIOLOGY (1989)
CHANG, C.J., MOLECULAR-CLONING OF A TRANSCRIPTION FACTOR, AGP EBP, THAT BELONGS TO MEMBERS OF THE C/EBP FAMILY, MOLECULAR AND CELLULAR BIOLOGY 10: 6642 (1990). / MOLECULAR AND CELLULAR BIOLOGY (1990)
CZERNIK, A.J., AMINO-ACID-SEQUENCES SURROUNDING THE CAMP-DEPENDENT AND CALCIUM CALMODULIN-DEPENDENT PHOSPHORYLATION SITES IN RAT AND BOVINE SYNAPSIN-I, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 7518 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
DASH, P.K., CAMP RESPONSE ELEMENT-BINDING PROTEIN IS ACTIVATED BY CA2+/CALMODULIN-DEPENDENT AS WELL AS CAMP-DEPENDENT PROTEIN-KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 5061 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
DESCOMBES, P, A LIVER-ENRICHED TRANSCRIPTIONAL ACTIVATOR PROTEIN, LAP, AND A TRANSCRIPTIONAL INHIBITORY PROTEIN, LIP, ARE TRANSLATED FROM THE SAME MESSENGER-RNA, CELL 67: 569 (1991). (10.1016/0092-8674(91)90531-3) / CELL (1991)
DESCOMBES, P, LAP, A NOVEL MEMBER OF THE C/EBP GENE FAMILY, ENCODES A LIVER-ENRICHED TRANSCRIPTIONAL ACTIVATOR PROTEIN, GENES & DEVELOPMENT 4: 1541 (1990). (10.1101/gad.4.9.1541) / GENES & DEVELOPMENT (1990)
ERONDU, N.E., REGIONAL DISTRIBUTION OF TYPE-II CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE IN RAT-BRAIN, JOURNAL OF NEUROSCIENCE 5: 3270 (1985). (10.1523/JNEUROSCI.05-12-03270.1985) / JOURNAL OF NEUROSCIENCE (1985)
FUKUNAGA, K, BIOMEDICAL RESEARCH-TOKYO 7: 405 (1986). (10.2220/biomedres.7.405) / BIOMEDICAL RESEARCH-TOKYO (1986)
GHOSH, S, ACTIVATION INVITRO OF NF-KAPPA-B BY PHOSPHORYLATION OF ITS INHIBITOR I-KAPPA-B, NATURE 344: 678 (1990). (10.1038/344678a0) / NATURE (1990)
10.1126/science.3749894
10.1126/science.22932
10.1126/science.3037704
HATADA, Y, CALMODULIN AND CA2+-DEPENDENT AND CALMODULIN-DEPENDENT PROTEIN-KINASE IN RAT ANTERIOR-PITUITARY GLAND, JOURNAL OF NEUROCHEMISTRY 40: 1082 (1983). (10.1111/j.1471-4159.1983.tb08096.x) / JOURNAL OF NEUROCHEMISTRY (1983)
KAPILOFF, M.S., CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE MEDIATES A PATHWAY FOR TRANSCRIPTIONAL REGULATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 3710 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
10.1126/science.1652153
KELLY, P.T., CHANGES IN THE SUBCELLULAR-DISTRIBUTION OF CALMODULIN-KINASE-II DURING BRAIN-DEVELOPMENT, DEVELOPMENTAL BRAIN RESEARCH 18: 211 (1985). (10.1016/0165-3806(85)90265-2) / DEVELOPMENTAL BRAIN RESEARCH (1985)
10.1016/0968-0004(90)90073-K
KENNELLY, P.J., CONSENSUS SEQUENCES AS SUBSTRATE-SPECIFICITY DETERMINANTS FOR PROTEIN-KINASES AND PROTEIN PHOSPHATASES, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 15555 (1991). (10.1016/S0021-9258(18)98436-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1991)
LANDSCHULZ, W.H., ISOLATION OF A RECOMBINANT COPY OF THE GENE ENCODING C/EBP, GENES & DEVELOPMENT 2: 786 (1988). (10.1101/gad.2.7.786) / GENES & DEVELOPMENT (1988)
LIN, C.R., MOLECULAR-CLONING OF A BRAIN-SPECIFIC CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 5962 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
MEANS, A.R., A NOVEL CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE AND A MALE GERM CELL-SPECIFIC CALMODULIN-BINDING PROTEIN ARE DERIVED FROM THE SAME GENE, MOLECULAR AND CELLULAR BIOLOGY 11: 3960 (1991). / MOLECULAR AND CELLULAR BIOLOGY (1991)
METZ, R, CAMP STIMULATES THE C/EBP-RELATED TRANSCRIPTION FACTOR RNFIL-6 TO TRANS-LOCATE TO THE NUCLEUS AND INDUCE C-FOS TRANSCRIPTION, GENES & DEVELOPMENT 5: 1754 (1991). (10.1101/gad.5.10.1754) / GENES & DEVELOPMENT (1991)
MONTMINY, M.R., IDENTIFICATION OF A CYCLIC-AMP-RESPONSIVE ELEMENT WITHIN THE RAT SOMATOSTATIN GENE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6682 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
MORGAN, J.I., ROLE OF ION FLUX IN THE CONTROL OF C-FOS EXPRESSION, NATURE 322: 552 (1986). (10.1038/322552a0) / NATURE (1986)
10.1126/science.3014651
10.1126/science.1948029
POLI, V, IL-6DBP, A NUCLEAR-PROTEIN INVOLVED IN INTERLEUKIN-6 SIGNAL TRANSDUCTION, DEFINES A NEW FAMILY OF LEUCINE ZIPPER PROTEINS RELATED TO C/EBP, CELL 63: 643 (1990). (10.1016/0092-8674(90)90459-R) / CELL (1990)
ROMAN, C, IG/EBP-1 - A UBIQUITOUSLY EXPRESSED IMMUNOGLOBULIN ENHANCER BINDING-PROTEIN THAT IS SIMILAR TO C/EBP AND HETERODIMERIZES WITH C/EBP, GENES & DEVELOPMENT 4: 1404 (1990). (10.1101/gad.4.8.1404) / GENES & DEVELOPMENT (1990)
RON D COMMUNICATION.
RYDEN, T.A., AVIAN RETROVIRAL LONG TERMINAL REPEATS BIND CCAAT ENHANCER-BINDING PROTEIN, MOLECULAR AND CELLULAR BIOLOGY 9: 1155 (1989). / MOLECULAR AND CELLULAR BIOLOGY (1989)
10.1126/science.1646483
STUDIER, F.W., USE OF BACTERIOPHAGE-T7 RNA-POLYMERASE TO DIRECT SELECTIVE HIGH-LEVEL EXPRESSION OF CLONED GENES, JOURNAL OF MOLECULAR BIOLOGY 189: 113 (1986). (10.1016/0022-2836(86)90385-2) / JOURNAL OF MOLECULAR BIOLOGY (1986)
TOKUMITSU, H, KN-62, 1-[N,O-BIS(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE, A SPECIFIC INHIBITOR OF CA-2+/CALMODULIN-DEPENDENT PROTEIN KINASE-II, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 4315 (1990). (10.1016/S0021-9258(19)39565-1) / JOURNAL OF BIOLOGICAL CHEMISTRY (1990)
10.1126/science.1987644
WEGNER M unpublished data.
WILLIAMS, S.C., A FAMILY OF C/EBP-RELATED PROTEINS CAPABLE OF FORMING COVALENTLY LINKED LEUCINE ZIPPER DIMERS INVITRO, GENES & DEVELOPMENT 5: 1553 (1991). (10.1101/gad.5.9.1553) / GENES & DEVELOPMENT (1991)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 6:33 p.m.)
Indexed	16 hours, 44 minutes ago (Aug. 26, 2025, 3:15 a.m.)
Issued	33 years, 4 months ago (April 17, 1992)
Published	33 years, 4 months ago (April 17, 1992)
Published Print	33 years, 4 months ago (April 17, 1992)

Funders 0

None

BibTeX

@article{Wegner_1992, title={Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ}, volume={256}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.256.5055.370}, DOI={10.1126/science.256.5055.370}, number={5055}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Wegner, Michael and Cao, Zhaodan and Rosenfeld, Michael G.}, year={1992}, month=apr, pages={370–373} }

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