DOI: 10.1126/science.2540528. Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

10.1126/science.2540528

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Quiescent T cells can be induced to express many genes by mitogen or antigen stimulation. The messenger RNAs of some of these genes undergo relatively rapid degradation compared to messenger RNAs from constitutively expressed genes. A T cell activation pathway that specifically regulates the stability of messenger RNAs for the lymphokines interleukin-2, interferon-γ, tumor necrosis factor-α, and granulocyte-macrophage colony-stimulating factor is induced by stimulation of the CD28 surface molecule. This pathway does not directly affect the steady-state messenger RNA level, transcription, or messenger RNA half-life of other T cell activation genes, including c- myc , c- fos , IL-2 receptor, and the 4F2HC surface antigen. These data show that stimuli received at the cell surface can alter gene expression by inducing specific changes in messenger RNA degradation.

Bibliography

Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G., & Thompson, C. B. (1989). Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway. Science, 244(4902), 339â343.

Authors 5

Tullia Lindstein (first)
Carl H. June (additional)
Jeffrey A. Ledbetter (additional)
Gregory Stella (additional)
Craig B. Thompson (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:39 p.m.)
Indexed	2 days, 6 hours ago (Aug. 27, 2025, 11:41 a.m.)
Issued	36 years, 4 months ago (April 21, 1989)
Published	36 years, 4 months ago (April 21, 1989)
Published Print	36 years, 4 months ago (April 21, 1989)

Funders 0

None

BibTeX

@article{Lindstein_1989, title={Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway}, volume={244}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2540528}, DOI={10.1126/science.2540528}, number={4902}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lindstein, Tullia and June, Carl H. and Ledbetter, Jeffrey A. and Stella, Gregory and Thompson, Craig B.}, year={1989}, month=apr, pages={339–343} }

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