elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints
10.1126/science.2539641
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The myb - ets -containing acute leukemia virus, E26, transforms myeloblasts and erythroblasts in culture and causes a mixed erythroid and myeloid leukemia in chicks. Genes ( ets -1, ets -2, and erg ) with variable relatedness to the v- ets oncogene of the E26 virus have been identified, cloned, and characterized in several species. Two new members ( elk -1 and elk -2) of the ets oncogene superfamily have now been identified. Nucleotide sequence analysis of the elk -1 cDNA clone revealed that this gene encodes a 428-residue protein whose predicted amino acid sequence showed 82% similarity to the 3′ region of v- ets . The elk or related sequences appear to be transcriptionally active in testis and lung. The elk cDNA probe detects two loci in the human genome, elk -1 and elk -2, which map to chromosome regions Xp11.2 and 14q32.3, respectively. These loci are near the translocation breakpoint seen in the t(X;18) (p11.2;q11.2), which is characteristic of synovial sarcoma, and the chromosome 14q32 breakpoints seen in ataxia telangiectasia and other T cell malignancies. This suggests the possibility that rearrangements of elk loci may be involved in pathogenesis of certain tumors.

Bibliography

Rao, V. N., Huebner, K., Isobe, M., ar-Rushdi, A., Croce, C. M., & Reddy, S. P. (1989). elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints. Science, 244(4900), 66–70.

Authors 6
  1. Veena N. Rao (first)
  2. Kay Huebner (additional)
  3. Masaharu Isobe (additional)
  4. Abbas ar-Rushdi (additional)
  5. Carlo M. Croce (additional)
  6. Shyam P. Reddy (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:19 a.m.)
Indexed 1 month, 2 weeks ago (July 8, 2025, 10:07 a.m.)
Issued 36 years, 4 months ago (April 7, 1989)
Published 36 years, 4 months ago (April 7, 1989)
Published Print 36 years, 4 months ago (April 7, 1989)
Funders 0

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@article{Rao_1989, title={elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints}, volume={244}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2539641}, DOI={10.1126/science.2539641}, number={4900}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rao, Veena N. and Huebner, Kay and Isobe, Masaharu and ar-Rushdi, Abbas and Croce, Carlo M. and Reddy, Shyam P.}, year={1989}, month=apr, pages={66–70} }