DOI: 10.1126/science.2536188. Transneuronal Transfer of Herpes Virus from Peripheral Nerves to Cortex and Brainstem

Transneuronal Transfer of Herpes Virus from Peripheral Nerves to Cortex and Brainstem

10.1126/science.2536188

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The transneuronal transfer of neurotropic viruses may represent an effective tool for tracing chains of connected neurons because replication of virus in the recipient neurons after transfer amplifies the "tracer signal." Herpes simplex virus type 1 was transferred transneuronally from forelimb and hindlimb nerves of rats to the cortical and brainstem neurons that project to the spinal enlargements to which the nerves receiving injections are connected. This transneuronal transfer of herpes simplex virus type 1 from peripheral nerves has the potential to be used to identify neurons in the brain that are related transsynaptically to different nerves and muscles.

Bibliography

Ugolini, G., Kuypers, H. G. J. M., & Strick, P. L. (1989). Transneuronal Transfer of Herpes Virus from Peripheral Nerves to Cortex and Brainstem. Science, 243(4887), 89â91.

Authors 3

G. Ugolini (first)
H. G. J. M. Kuypers (additional)
P. L. Strick (additional)

References 34 Referenced 139

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 9:42 a.m.)
Indexed	3 months, 1 week ago (May 14, 2025, 3:45 p.m.)
Issued	36 years, 7 months ago (Jan. 6, 1989)
Published	36 years, 7 months ago (Jan. 6, 1989)
Published Print	36 years, 7 months ago (Jan. 6, 1989)

Funders 0

None

BibTeX

@article{Ugolini_1989, title={Transneuronal Transfer of Herpes Virus from Peripheral Nerves to Cortex and Brainstem}, volume={243}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2536188}, DOI={10.1126/science.2536188}, number={4887}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ugolini, G. and Kuypers, H. G. J. M. and Strick, P. L.}, year={1989}, month=jan, pages={89–91} }

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