DOI: 10.1126/science.2471266. Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

10.1126/science.2471266

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cytotoxic T lymphocytes (CTLs) recognize foreign antigens, including viral proteins, in association with major histocompatibility complex (MHC) class I molecules. Brefeldin A, a specific inhibitor of exocytosis, completely and reversibly inhibited the presentation of viral proteins, but not exogenous peptides, to MHC class I-restricted CTLs directed against influenza virus antigens. The effect of brefeldin A on antigen presentation correlated with its inhibition of intracellular transport of newly synthesized class I molecules. Brefeldin A is thus a specific inhibitor of antigen processing for class I-restricted T cell recognition. Its effect on antigen presentation supports the idea that exogenous peptide antigens associate with cell surface class I molecules, whereas protein antigens processed via the cytosolic route associate with nascent class I molecules before they leave the trans-Golgi complex.

Bibliography

Yewdell, J. W., & Bennink, J. R. (1989). Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes. Science, 244(4908), 1072â1075.

Authors 2

Jonthan W. Yewdell (first)
Jack R. Bennink (additional)

References 29 Referenced 244

ANDERSSON, M, IMPAIRED INTRACELLULAR-TRANSPORT OF CLASS-I MHC ANTIGENS AS A POSSIBLE MEANS FOR ADENOVIRUSES TO EVADE IMMUNE SURVEILLANCE, CELL 43: 215 (1985). (10.1016/0092-8674(85)90026-1) / CELL (1985)
BASTIN, J, USE OF SYNTHETIC PEPTIDES OF INFLUENZA NUCLEOPROTEIN TO DEFINE EPITOPES RECOGNIZED BY CLASS-I-RESTRICTED CYTOTOXIC LYMPHOCYTES-T, JOURNAL OF EXPERIMENTAL MEDICINE 165: 1508 (1987). (10.1084/jem.165.6.1508) / JOURNAL OF EXPERIMENTAL MEDICINE (1987)
BENNINK, J.R., MURINE CYTO-TOXIC LYMPHOCYTE-T RECOGNITION OF INDIVIDUAL INFLUENZA-VIRUS PROTEINS - HIGH-FREQUENCY OF NONRESPONDER MHC CLASS-I ALLELES, JOURNAL OF EXPERIMENTAL MEDICINE 168: 1935 (1988). (10.1084/jem.168.5.1935) / JOURNAL OF EXPERIMENTAL MEDICINE (1988)
BENNINK, J.R., ANTIINFLUENZA VIRUS CYTOTOXIC LYMPHOCYTES-T RECOGNIZE THE 3 VIRAL POLYMERASES AND A NONSTRUCTURAL PROTEIN - RESPONSIVENESS TO INDIVIDUAL VIRAL-ANTIGENS IS MAJOR HISTOCOMPATIBILITY COMPLEX CONTROLLED, JOURNAL OF VIROLOGY 61: 1098 (1987). (10.1128/jvi.61.4.1098-1102.1987) / JOURNAL OF VIROLOGY (1987)
BERZOFSKY, J. A., IMMUNOLOGICAL REVIEWS 98: 9 (1987). (10.1111/j.1600-065X.1987.tb00518.x) / IMMUNOLOGICAL REVIEWS (1987)
BURGERT, H.G., AN ADENOVIRUS TYPE-2 GLYCOPROTEIN BLOCKS CELL-SURFACE EXPRESSION OF HUMAN HISTOCOMPATIBILITY CLASS-I ANTIGENS, CELL 41: 987 (1985). (10.1016/S0092-8674(85)80079-9) / CELL (1985)
COPELAND, C.S., FOLDING, TRIMERIZATION, AND TRANSPORT ARE SEQUENTIAL EVENTS IN THE BIOGENESIS OF INFLUENZA-VIRUS HEMAGGLUTININ, CELL 53: 197 (1988). (10.1016/0092-8674(88)90381-9) / CELL (1988)
COUPAR, BEH, IMMUNE-RESPONSES TO H-2KD ANTIGEN EXPRESSED BY RECOMBINANT VACCINIA VIRUS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 7879 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
Doms, R. W., Journal of Cell Biology 109: 61 (1989). (10.1083/jcb.109.1.61) / Journal of Cell Biology (1989)
EAGER K.B. unpublished data.
EISENLOHR, L.C., ROLE OF RECEPTOR-BINDING ACTIVITY OF THE VIRAL HEMAGGLUTININ MOLECULE IN THE PRESENTATION OF INFLUENZA-VIRUS ANTIGENS TO HELPER T-CELLS, JOURNAL OF VIROLOGY 61: 1375 (1987). (10.1128/jvi.61.5.1375-1383.1987) / JOURNAL OF VIROLOGY (1987)
FUJIWARA, T, BREFELDIN-A CAUSES DISASSEMBLY OF THE GOLGI-COMPLEX AND ACCUMULATION OF SECRETORY PROTEINS IN THE ENDOPLASMIC-RETICULUM, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 18545 (1988). (10.1016/S0021-9258(19)81393-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1988)
Gething, M.-J., Cell 46: 939 (1986). (10.1016/0092-8674(86)90076-0) / Cell (1986)
HOSAKA, Y, RECOGNITION OF NONINFECTIOUS INFLUENZA-VIRUS BY CLASS-I-RESTRICTED MURINE CYTO-TOXIC LYMPHOCYTES-T, JOURNAL OF IMMUNOLOGY 140: 606 (1988). (10.4049/jimmunol.140.2.606) / JOURNAL OF IMMUNOLOGY (1988)
10.1016/0092-8674(89)90975-6
MAGNER, J.A., BLOCKADE BY BREFELDIN A OF INTRACELLULAR-TRANSPORT OF SECRETORY PROTEINS IN MOUSE PITUITARY-CELLS - EFFECTS ON THE BIOSYNTHESIS OF THYROTROPIN AND FREE ALPHA-SUBUNITS, ENDOCRINOLOGY 122: 912 (1988). (10.1210/endo-122-3-912) / ENDOCRINOLOGY (1988)
MISUMI, Y, NOVEL BLOCKADE BY BREFELDIN-A OF INTRACELLULAR-TRANSPORT OF SECRETORY PROTEINS IN CULTURED RAT HEPATOCYTES, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 11398 (1986). (10.1016/S0021-9258(18)67398-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1986)
10.1016/S0092-8674(88)91043-4
RUSS G unpublished data.
SCHWARTZ, R.H., ADVANCES IN IMMUNOLOGY 38: 31 (1986). (10.1016/S0065-2776(08)60006-1) / ADVANCES IN IMMUNOLOGY (1986)
TAKATSUKI, A, BREFELDIN-A, A SPECIFIC INHIBITOR OF INTRACELLULAR TRANSLOCATION OF VESICULAR STOMATITIS VIRUS-G PROTEIN - INTRACELLULAR ACCUMULATION OF HIGH-MANNOSE TYPE-G PROTEIN AND INHIBITION OF ITS CELL-SURFACE EXPRESSION, AGRICULTURAL AND BIOLOGICAL CHEMISTRY 49: 899 (1985). / AGRICULTURAL AND BIOLOGICAL CHEMISTRY (1985)
TANAKA, Y, VIROLOGY 165: 357 (1988). (10.1016/0042-6822(88)90580-6) / VIROLOGY (1988)
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10.1126/science.2437650
WILLIAMS, D.B., INTRACELLULAR-TRANSPORT OF MEMBRANE-GLYCOPROTEINS - 2 CLOSELY RELATED HISTOCOMPATIBILITY ANTIGENS DIFFER IN THEIR RATES OF TRANSIT TO THE CELL-SURFACE, JOURNAL OF CELL BIOLOGY 101: 725 (1985). (10.1083/jcb.101.3.725) / JOURNAL OF CELL BIOLOGY (1985)
YEWDELL, J.W., MONOCLONAL-ANTIBODIES LOCALIZE EVENTS IN THE FOLDING, ASSEMBLY, AND INTRACELLULAR-TRANSPORT OF THE INFLUENZA-VIRUS HEMAGGLUTININ GLYCOPROTEIN, CELL 52: 843 (1988). (10.1016/0092-8674(88)90426-6) / CELL (1988)
10.1126/science.3257585
YEWDELL J.W. unpublished data.
ZINKERNAGEL, R.M., ADVANCES IN IMMUNOLOGY 27: 51 (1979). (10.1016/S0065-2776(08)60262-X) / ADVANCES IN IMMUNOLOGY (1979)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 5:21 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 10:55 a.m.)
Indexed	5 months ago (March 31, 2025, 10:05 a.m.)
Issued	36 years, 3 months ago (June 2, 1989)
Published	36 years, 3 months ago (June 2, 1989)
Published Print	36 years, 3 months ago (June 2, 1989)

Funders 0

None

BibTeX

@article{Yewdell_1989, title={Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes}, volume={244}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2471266}, DOI={10.1126/science.2471266}, number={4908}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yewdell, Jonthan W. and Bennink, Jack R.}, year={1989}, month=jun, pages={1072–1075} }

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