DOI: 10.1126/science.2442813. Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

10.1126/science.2442813

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth factor-β (TGF-β), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-β on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-β. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-β. TGF-β is thus a potent pharmacologic agent that can accelerate wound healing in rats.

Bibliography

Mustoe, T. A., Pierce, G. F., Thomason, A., Gramates, P., Sporn, M. B., & Deuel, T. F. (1987). Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-Î². Science, 237(4820), 1333â1336.

Authors 6

Thomas A. Mustoe (first)
Glenn F. Pierce (additional)
Arlen Thomason (additional)
Peggy Gramates (additional)
Michael B. Sporn (additional)
Thomas F. Deuel (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 9:44 a.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 12:22 a.m.)
Issued	37 years, 11 months ago (Sept. 11, 1987)
Published	37 years, 11 months ago (Sept. 11, 1987)
Published Print	37 years, 11 months ago (Sept. 11, 1987)

Funders 0

None

BibTeX

@article{Mustoe_1987, title={Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β}, volume={237}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2442813}, DOI={10.1126/science.2442813}, number={4820}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Mustoe, Thomas A. and Pierce, Glenn F. and Thomason, Arlen and Gramates, Peggy and Sporn, Michael B. and Deuel, Thomas F.}, year={1987}, month=sep, pages={1333–1336} }

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