The Chemistry of Self-Splicing RNA and RNA Enzymes
10.1126/science.2438771
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Proteins are not the only catalysts of cellular reactions; there is a growing list of RNA molecules that catalyze RNA cleavage and joining reactions. The chemical mechanisms of RNA-catalyzed reactions are discussed with emphasis on the self-splicing ribosomal RNA precursor of Tetrahymena and the enzymatic activities of its intervening sequence RNA. Wherever appropriate, catalysis by RNA is compared to catalysis by protein enzymes.

Bibliography

Cech, T. R. (1987). The Chemistry of Self-Splicing RNA and RNA Enzymes. Science, 236(4808), 1532–1539.

Authors 1
  1. Thomas R. Cech (first)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 11:52 a.m.)
Indexed 3 days, 7 hours ago (Aug. 29, 2025, 5:41 a.m.)
Issued 38 years, 2 months ago (June 19, 1987)
Published 38 years, 2 months ago (June 19, 1987)
Published Print 38 years, 2 months ago (June 19, 1987)
Funders 0

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@article{Cech_1987, title={The Chemistry of Self-Splicing RNA and RNA Enzymes}, volume={236}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2438771}, DOI={10.1126/science.2438771}, number={4808}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cech, Thomas R.}, year={1987}, month=jun, pages={1532–1539} }