DOI: 10.1126/science.2422759. Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

10.1126/science.2422759

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are structurally related peptides. Purified human TGF-α produced in Escherichia coli and pure natural mouse EGF were compared for their ability to bind to target cells in vitro and to promote angiogenesis in the hamster cheek pouch bioassay. Both polypeptides were found to bind in vitro to several target cells, including endothelial cells, and to stimulate their DNA synthesis in an equipotent fashion. In vivo, however, TGF-α was more potent than EGF in promoting angiogenesis and, because TGF-α is known to be secreted by a variety of human tumors, it is suggested that this growth factor may contribute to tumor-induced angiogenesis.

Bibliography

Schreiber, A. B., Winkler, M. E., & Derynck, R. (1986). Transforming Growth Factor-Î±: a More Potent Angiogenic Mediator than Epidermal Growth Factor. Science, 232(4755), 1250â1253.

Authors 3

Alain B. Schreiber (first)
Marjorie E. Winkler (additional)
Rik Derynck (additional)

References 34 Referenced 609

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 4:28 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 9:30 a.m.)
Indexed	1 week, 3 days ago (Aug. 26, 2025, 2:23 a.m.)
Issued	39 years, 3 months ago (June 6, 1986)
Published	39 years, 3 months ago (June 6, 1986)
Published Print	39 years, 3 months ago (June 6, 1986)

Funders 0

None

BibTeX

@article{Schreiber_1986, title={Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor}, volume={232}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2422759}, DOI={10.1126/science.2422759}, number={4755}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schreiber, Alain B. and Winkler, Marjorie E. and Derynck, Rik}, year={1986}, month=jun, pages={1250–1253} }

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