DOI: 10.1126/science.2412295. Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III

Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III

10.1126/science.2412295

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4 + peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.

Bibliography

Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., MacKey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W. (1985). Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III. Science, 230(4721), 71â73.

Authors 10

N. L. Letvin (first)
M. D. Daniel (additional)
P. K. Sehgal (additional)
R. C. Desrosiers (additional)
R. D. Hunt (additional)
L. M. Waldron (additional)
J. J. MacKey (additional)
D. K. Schmidt (additional)
L. V. Chalifoux (additional)
N. W. King (additional)

References 17 Referenced 490

MORBIDITY AND MORTALITY WEEKLY REPORT 33: 442 (1984). / MORBIDITY AND MORTALITY WEEKLY REPORT (1984)
10.1126/science.6093251
10.1126/science.3159089
FAUCI, A.S., THE ACQUIRED IMMUNODEFICIENCY SYNDROME - AN UPDATE, ANNALS OF INTERNAL MEDICINE 102: 800 (1985). (10.7326/0003-4819-102-6-800) / ANNALS OF INTERNAL MEDICINE (1985)
GAJDUSEK, D.C., TRANSMISSION EXPERIMENTS WITH HUMAN T-LYMPHOTROPIC RETROVIRUSES AND HUMAN AIDS TISSUE, LANCET 1: 1415 (1984). / LANCET (1984)
GAJDUSEK, D.C., INFECTION OF CHIMPANZEES BY HUMAN T-LYMPHOTROPIC RETROVIRUSES IN BRAIN AND OTHER TISSUES FROM AIDS PATIENTS, LANCET 1: 55 (1985). / LANCET (1985)
HENRICKSON, R.V., EPIDEMIC OF ACQUIRED IMMUNODEFICIENCY IN RHESUS-MONKEYS, LANCET 1: 388 (1983). / LANCET (1983)
Hunt, R. D., Proceedings of the National Academy of Sciences of the United States of America 80: 5085 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
10.1126/science.3873705
KING, N.W., HISTOPATHOLOGIC CHANGES IN MACAQUES WITH AN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), AMERICAN JOURNAL OF PATHOLOGY 113: 382 (1983). / AMERICAN JOURNAL OF PATHOLOGY (1983)
LETVIN, N.L., CLINICAL AND PATHOLOGIC FEATURES OF AN ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) IN MACAQUE MONKEYS, ADVANCES IN VETERINARY SCIENCE AND COMPARATIVE MEDICINE 28: 237 (1984). (10.1016/B978-0-12-039228-5.50013-9) / ADVANCES IN VETERINARY SCIENCE AND COMPARATIVE MEDICINE (1984)
LETVIN, N.L., LYMPHOCYTE-T SURFACE-ANTIGENS IN PRIMATES, EUROPEAN JOURNAL OF IMMUNOLOGY 13: 345 (1983). (10.1002/eji.1830130414) / EUROPEAN JOURNAL OF IMMUNOLOGY (1983)
LETVIN, N.L., EXPERIMENTAL-INFECTION OF RHESUS-MONKEYS WITH TYPE-D RETROVIRUS, JOURNAL OF VIROLOGY 52: 683 (1984). (10.1128/jvi.52.2.683-686.1984) / JOURNAL OF VIROLOGY (1984)
LETVIN, N.L., EXPERIMENTAL TRANSMISSION OF MACAQUE AIDS BY MEANS OF INOCULATION OF MACAQUE LYMPHOMA TISSUE, LANCET 2: 599 (1983). / LANCET (1983)
Letvin, N. L., Proceedings of the National Academy of Sciences of the United States of America 80: 2718 (1983). / Proceedings of the National Academy of Sciences of the United States of America (1983)
10.1126/science.6695196
10.1126/science.2981429

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 9:32 a.m.)
Indexed	1 day, 9 hours ago (Sept. 3, 2025, 6:38 a.m.)
Issued	39 years, 11 months ago (Oct. 4, 1985)
Published	39 years, 11 months ago (Oct. 4, 1985)
Published Print	39 years, 11 months ago (Oct. 4, 1985)

Funders 0

None

BibTeX

@article{Letvin_1985, title={Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III}, volume={230}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2412295}, DOI={10.1126/science.2412295}, number={4721}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Letvin, N. L. and Daniel, M. D. and Sehgal, P. K. and Desrosiers, R. C. and Hunt, R. D. and Waldron, L. M. and MacKey, J. J. and Schmidt, D. K. and Chalifoux, L. V. and King, N. W.}, year={1985}, month=oct, pages={71–73} }

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