DOI: 10.1126/science.2321006. Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

10.1126/science.2321006

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and characterization of additional such factors has been impeded by their low abundance. Sequence homologies between NGF and the recently cloned brain-derived neurotrophic factor (BDNF) were used to design a strategy that has now resulted in the cloning of a gene encoding a novel neurotrophic factor, termed neurotrophin-3 (NT-3). The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguish NT-3 from NGF and BDNF, and provide compelling evidence that NT-3 is an authentic neurotrophic factor that has its own characteristic role in vivo.

Bibliography

Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990). Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF. Science, 247(4949), 1446â1451.

Authors 7

Peter C. Maisonpierre (first)
Leonardo Belluscio (additional)
Stephen Squinto (additional)
Nancy Y. Ip (additional)
Mark E. Furth (additional)
Ronald M. Lindsay (additional)
George D. Yancopoulos (additional)

References 47 Referenced 980

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:23 a.m.)
Indexed	41 minutes ago (Sept. 2, 2025, 12:05 p.m.)
Issued	35 years, 5 months ago (March 23, 1990)
Published	35 years, 5 months ago (March 23, 1990)
Published Print	35 years, 5 months ago (March 23, 1990)

Funders 0

None

BibTeX

@article{Maisonpierre_1990, title={Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF}, volume={247}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2321006}, DOI={10.1126/science.2321006}, number={4949}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Maisonpierre, Peter C. and Belluscio, Leonardo and Squinto, Stephen and Ip, Nancy Y. and Furth, Mark E. and Lindsay, Ronald M. and Yancopoulos, George D.}, year={1990}, month=mar, pages={1446–1451} }

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