DOI: 10.1126/science.2296722. A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

10.1126/science.2296722

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.

Bibliography

Moser, A. R., Pitot, H. C., & Dove, W. F. (1990). A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse. Science, 247(4940), 322â324.

Authors 3

Amy Rapaich Moser (first)
Henry C. Pitot (additional)
William F. Dove (additional)

References 19 Referenced 1,241

10.1126/science.6336308
BOMAN, B.M., FAMILIAL POLYPOSIS, HOSPITAL PRACTICE 21: 155 (1986). / HOSPITAL PRACTICE (1986)
CORY, S, TRANSGENIC MICE AND ONCOGENESIS, ANNUAL REVIEW OF IMMUNOLOGY 6: 25 (1988). (10.1146/annurev.iy.06.040188.000325) / ANNUAL REVIEW OF IMMUNOLOGY (1988)
ECKERT, K.A., MOLECULAR ANALYSIS OF MUTATIONS INDUCED IN HUMAN-CELLS BY N-ETHYL-N-NITROSOUREA, MOLECULAR CARCINOGENESIS 1: 50 (1988). (10.1002/mc.2940010111) / MOLECULAR CARCINOGENESIS (1988)
10.1038/336374a0
HAGGITT, R.C., HEREDITARY GASTROINTESTINAL POLYPOSIS SYNDROMES, AMERICAN JOURNAL OF SURGICAL PATHOLOGY 10: 871 (1986). (10.1097/00000478-198612000-00006) / AMERICAN JOURNAL OF SURGICAL PATHOLOGY (1986)
HANAHAN, D, DISSECTING MULTISTEP TUMORIGENESIS IN TRANSGENIC MICE, ANNUAL REVIEW OF GENETICS 22: 479 (1988). (10.1146/annurev.ge.22.120188.002403) / ANNUAL REVIEW OF GENETICS (1988)
10.1073/pnas.82.18.6216
HITOTSUMACHI, S, DOSE-REPETITION INCREASES THE MUTAGENIC EFFECTIVENESS OF N-ETHYL-N-NITROSOUREA IN MOUSE SPERMATOGONIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 6619 (1985). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1985)
10.1073/pnas.68.4.820
LYNCH, H.T., GASTROINTESTINAL CAN: 297 (1981). / GASTROINTESTINAL CAN (1981)
RUSSELL, W.L., ENVIRON MOL MUTAGEN 14: 168 (1989). / ENVIRON MOL MUTAGEN (1989)
SHEDLOVSKY, A, INDUCTION OF RECESSIVE LETHAL MUTATIONS IN THE T/T-H-2 REGION OF THE MOUSE GENOME BY A POINT MUTAGEN, GENETICAL RESEARCH 47: 135 (1986). (10.1017/S0016672300022977) / GENETICAL RESEARCH (1986)
SIRICA, A.E., PATHOBIOLOGY NEOPLAS: 33 (1989). / PATHOBIOLOGY NEOPLAS (1989)
10.1126/science.7375916
10.1126/science.6823558
SWAROOP, V.S., MULTIPLE PRIMARY MALIGNANT-TUMORS, GASTROENTEROLOGY 93: 779 (1987). (10.1016/0016-5085(87)90440-9) / GASTROENTEROLOGY (1987)
VOGEL, E, RELATION BETWEEN REACTION-KINETICS AND MUTAGENIC ACTION OF MONO-FUNCTIONAL ALKYLATING-AGENTS IN HIGHER EUKARYOTIC SYSTEMS .1. RECESSIVE LETHAL MUTATIONS AND TRANSLOCATIONS IN DROSOPHILA, MUTATION RESEARCH 62: 51 (1979). (10.1016/0027-5107(79)90223-9) / MUTATION RESEARCH (1979)
10.1056/NEJM198809013190901

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:11 a.m.)
Indexed	1 week ago (Aug. 20, 2025, 8:44 a.m.)
Issued	35 years, 7 months ago (Jan. 19, 1990)
Published	35 years, 7 months ago (Jan. 19, 1990)
Published Print	35 years, 7 months ago (Jan. 19, 1990)

Funders 0

None

BibTeX

@article{Moser_1990, title={A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse}, volume={247}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2296722}, DOI={10.1126/science.2296722}, number={4940}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Moser, Amy Rapaich and Pitot, Henry C. and Dove, William F.}, year={1990}, month=jan, pages={322–324} }

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