Phosphorylated Proteins as Physiological Effectors
10.1126/science.22932
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues. The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP. These and other observations suggest that many different classes of regulatory substances achieve certain of their biological effects by altering the phosphorylation of specific proteins.

Bibliography

Greengard, P. (1978). Phosphorylated Proteins as Physiological Effectors. Science, 199(4325), 146–152.

Authors 1
  1. Paul Greengard (first)
References 131 Referenced 749
  1. Adelstein, R. S., Cold Spring Harbor Conferences on Cell Proliferation 3: 725 (1976). / Cold Spring Harbor Conferences on Cell Proliferation (1976)
  2. ADELSTEIN, R.S., PHOSPHORYLATION OF PLATELET MYOSIN INCREASES ACTIN-ACTIVATED MYOSIN ATPASE ACTIVITY, NATURE 256: 597 (1975). (10.1038/256597a0) / NATURE (1975)
  3. AHMED, K, CHROMATIN-ASSOCIATED PROTEIN PHOSPHOKINASES OF RAT VENTRAL PROSTATE - CHARACTERISTICS AND EFFECTS OF ANDROGENIC STATUS, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 2370 (1975). (10.1016/S0021-9258(19)41726-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1975)
  4. AVRUCH, J, EFFECTS OF EPINEPHRINE AND INSULIN ON PHOSPHOPEPTIDE METABOLISM IN ADIPOCYTES, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 1511 (1976). (10.1016/S0021-9258(17)33770-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1976)
  5. BAKER, P. F., JOURNAL OF PHYSIOLOGY-LONDON 218: 709 (1971). (10.1113/jphysiol.1971.sp009641) / JOURNAL OF PHYSIOLOGY-LONDON (1971)
  6. BEAM, K.G., INCREASED CYCLIC-GMP LEVELS ASSOCIATED WITH CONTRACTION IN MUSCLE-FIBERS OF GIANT BARNACLE, NATURE 267: 534 (1977). (10.1038/267534a0) / NATURE (1977)
  7. BENJAMIN, W.B., ACTIONS OF INSULIN, EPINEPHRINE, AND DIBUTYRYL CYCLIC ADENOSINE 5'-MONOPHOSPHATE ON FAT-CELL PROTEIN PHOSPHORYLATIONS - CYCLIC ADENOSINE 5'-MONOPHOSPHATE DEPENDENT AND INDEPENDENT MECHANISMS, BIOCHEMISTRY 14: 3301 (1975). (10.1021/bi00686a003) / BIOCHEMISTRY (1975)
  8. BENJAMIN, W.B., EFFECT OF INSULIN ON PHOSPHORYLATION OF ADIPOSE-TISSUE PROTEIN, BIOCHIMICA ET BIOPHYSICA ACTA 351: 28 (1974). (10.1016/0005-2795(74)90063-4) / BIOCHIMICA ET BIOPHYSICA ACTA (1974)
  9. BOWNDS, D, NATURE-NEW BIOLOGY 237: 125 (1972). / NATURE-NEW BIOLOGY (1972)
  10. BRONAUGH, R.L., NEUROSCIENCE ABSTRACTS: 547 (1975). / NEUROSCIENCE ABSTRACTS (1975)
  11. BROSTROM, C.O., INTERACTION SUBUNITS OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE-DEPENDENT PROTEIN KINASE OF MUSCLE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 2444 (1971). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1971)
  12. BROSTROM, M.A., ADV ENZYME REGUL 8: 191 (1970). (10.1016/0065-2571(70)90017-8) / ADV ENZYME REGUL (1970)
  13. BUTCHER, F.R., ADRENERGIC REGULATION OF CYCLIC NUCLEOTIDE LEVELS, AMYLASE RELEASE, AND POTASSIUM EFFLUX IN RAT PAROTID-GLAND, MOLECULAR PHARMACOLOGY 12: 862 (1976). / MOLECULAR PHARMACOLOGY (1976)
  14. CASNELLIE, J.E., GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE-DEPENDENT PHOSPHORYLATION OF ENDOGENOUS SUBSTRATE PROTEINS IN MEMBRANES OF MAMMALIAN SMOOTH-MUSCLE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 1891 (1974). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1974)
  15. CASNELLIE J.E. UNPUBLISHED OBSERVATIONS.
  16. CHACKO, S, EFFECT OF PHOSPHORYLATION OF SMOOTH-MUSCLE MYOSIN ON ACTIN ACTIVATION AND CA2+ REGULATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 129 (1977). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1977)
  17. Chalfie M. in preparation.
  18. CLYMAN, R.I., GUANOSINE 3',5'-MONOPHOSPHATE AND ADENOSINE-3',5'-MONOPHOSPHATE CONTENT OF HUMAN UMBILICAL ARTERY - POSSIBLE ROLE IN PERINATAL ARTERIAL PATENCY AND CLOSURE, JOURNAL OF CLINICAL INVESTIGATION 55: 1020 (1975). (10.1172/JCI108002) / JOURNAL OF CLINICAL INVESTIGATION (1975)
  19. COFFINO, P, Molecular Mechanisms of Cyclic AMP Action: A Genetic Approach, RECENT PROGRESS IN HORMONE RESEARCH 32: 669 (1976). / RECENT PROGRESS IN HORMONE RESEARCH / Molecular Mechanisms of Cyclic AMP Action: A Genetic Approach (1976)
  20. COHEN, M.E., STIMULATION OF UTERINE NONHISTONE PROTEIN-PHOSPHORYLATION AND NUCLEAR PROTEIN-KINASE ACTIVITY BY ESTRADIOL-17BETA, BIOCHIMICA ET BIOPHYSICA ACTA 435: 159 (1976). (10.1016/0005-2787(76)90247-1) / BIOCHIMICA ET BIOPHYSICA ACTA (1976)
  21. CORBIN, J.D., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 5: 265 (1975). / ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH (1975)
  22. DANIEL, J.L., ISOLATION AND PROPERTIES OF PLATELET MYOSIN LIGHT CHAIN KINASE, BIOCHEMISTRY 15: 2370 (1976). (10.1021/bi00656a019) / BIOCHEMISTRY (1976)
  23. DATTA, A, ROLE OF 3'-5'-CYCLIC-AMP-DEPENDENT PROTEIN-KINASE IN REGULATION OF PROTEIN-SYNTHESIS IN RETICULOCYTE LYSATES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 1463 (1977). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1977)
  24. DEJONGE, H.R., CYCLIC NUCLEOTIDE-DEPENDENT PHOSPHORYLATION OF INTESTINAL EPITHELIUM PROTEINS, NATURE 262: 590 (1976). (10.1038/262590a0) / NATURE (1976)
  25. DELORENZO, R.J., REGULATION OF PHOSPHORYLATION OF A SPECIFIC PROTEIN IN TOAD-BLADDER MEMBRANE BY ANTIDIURETIC-HORMONE AND CYCLIC-AMP, AND ITS POSSIBLE RELATIONSHIP TO MEMBRANE-PERMEABILITY CHANGES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 880 (1973). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1973)
  26. DENTON, R.M., REGULATION OF MAMMALIAN PYRUVATE-DEHYDROGENASE, MOLECULAR AND CELLULAR BIOCHEMISTRY 9: 27 (1975). (10.1007/BF01731731) / MOLECULAR AND CELLULAR BIOCHEMISTRY (1975)
  27. DOUGLAS, W.W., STIMULUS-SECRETION COUPLING - CONCEPT AND CLUES FROM CHROMAFFIN AND OTHER CELLS, BRITISH JOURNAL OF PHARMACOLOGY 34: 451 (1968). (10.1111/j.1476-5381.1968.tb08474.x) / BRITISH JOURNAL OF PHARMACOLOGY (1968)
  28. ERLICHMAN, J, INTERCONVERSION OF CYCLIC NUCLEOTIDE-ACTIVATED AND CYCLIC NUCLEOTIDE-INDEPENDENT FORMS OF A PROTEIN KINASE FROM BEEF HEART, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 731 (1971). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1971)
  29. FERRENDELLI, J.A., EFFECT OF OXOTREMORINE AND ATROPINE ON CGMP AND CAMP LEVELS IN MOUSE CEREBRAL CORTEX AND CEREBELLUM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 41: 1061 (1970). (10.1016/0006-291X(70)90193-2) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1970)
  30. FORN, J, REGULATION BY LIPOLYTIC AND ANTILIPOLYTIC COMPOUNDS OF PHOSPHORYLATION OF SPECIFIC PROTEINS IN ISOLATED INTACT FAT-CELLS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 176: 721 (1976). (10.1016/0003-9861(76)90216-2) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1976)
  31. FREARSON, N, PHOSPHORYLATION OF LIGHT-CHAIN COMPONENTS OF MYOSIN FROM CARDIAC AND RED SKELETAL-MUSCLES, BIOCHEMICAL JOURNAL 151: 99 (1975). (10.1042/bj1510099) / BIOCHEMICAL JOURNAL (1975)
  32. FREARSON, N, PHOSPHORYLATION OF A LIGHT CHAIN COMPONENT OF MYOSIN FROM SMOOTH-MUSCLE, FEBS LETTERS 63: 27 (1976). (10.1016/0014-5793(76)80187-1) / FEBS LETTERS (1976)
  33. GEORGE, W.J., ELEVATION OF GUANOSINE 3',5'-CYCLIC PHOSPHATE IN RAT HEART AFTER PERFUSION WITH ACETYLCHOLINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 66: 398 (1970). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1970)
  34. GILL, G.N., A CYCLIC-3',5'-ADENOSINE MONOPHOSPHATE DEPENDENT PROTEIN KINASE FROM ADRENAL CORTEX - COMPARISON WITH A CYCLIC AMP BINDING PROTEIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 39: 335 (1970). (10.1016/0006-291X(70)90581-4) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1970)
  35. GILL, G.N., PURIFICATION AND CHARACTERIZATION OF 3'-5'-CYCLIC GMP-DEPENDENT PROTEIN-KINASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3918 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  36. GOODMAN, DBP, CYCLIC ADENOSINE 3'-5'-MONOPHOSPHATE-STIMULATED PHOSPHORYLATION OF ISOLATED NEUROTUBULE SUBUNITS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 652 (1970). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1970)
  37. GORECKA, A, EFFECT OF PHOSPHORYLATION OF GIZZARD MYOSIN ON ACTIN ACTIVATION, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 71: 325 (1976). (10.1016/0006-291X(76)90286-2) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1976)
  38. GREENGARD, P, ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 5: 585 (1975). / ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH (1975)
  39. GREENGARD, P, ADVANCES BIOCHEMICAL 3: 287 (1970). / ADVANCES BIOCHEMICAL (1970)
  40. GREENGARD, P, POSSIBLE ROLE FOR CYCLIC NUCLEOTIDES AND PHOSPHORYLATED MEMBRANE PROTEINS IN POSTSYNAPTIC ACTIONS OF NEUROTRANSMITTERS, NATURE 260: 101 (1976). (10.1038/260101a0) / NATURE (1976)
  41. GRESSNER, A.M., STIMULATION OF PHOSPHORYLATION OF RIBOSOMAL PROTEIN-S6 BY CYCLOHEXIMIDE AND PUROMYCIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 60: 1482 (1974). (10.1016/0006-291X(74)90365-9) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1974)
  42. HALEY, B.E., PHOTOAFFINITY LABELING OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE BINDING-SITES OF HUMAN RED-CELL MEMBRANES, BIOCHEMISTRY 14: 3852 (1975). (10.1021/bi00688a018) / BIOCHEMISTRY (1975)
  43. HAYMOVITS, A, CELLULAR CYCLIC NUCLEOTIDES AND ENZYME-SECRETION IN PANCREATIC ACINAR CELL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 156 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  44. HOFMANN, F, PROTEIN KINASE-ACTIVITY FROM RAT CEREBELLUM STIMULATED BY GUANOSINE-5-MONOPHOSPHATE -, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 49: 1100 (1972). (10.1016/0006-291X(72)90326-9) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1972)
  45. IGNARRO, L.J., STIMULATION OF PHAGOCYTIC RELEASE OF NEUTRAL PROTEASE FROM HUMAN NEUTROPHILS BY CHOLINERGIC AMINES AND CYCLIC 3',5'-GUANOSINE MONOPHOSPHATE, JOURNAL OF IMMUNOLOGY 112: 210 (1974). (10.4049/jimmunol.112.1.210) / JOURNAL OF IMMUNOLOGY (1974)
  46. 10.1126/science.171770
  47. IVES, H. E., JOURNAL OF CELL BIOLOGY 75: A325 (1977). / JOURNAL OF CELL BIOLOGY (1977)
  48. JONGE, HRD, J BIOL CHEM 252: 2780 (1977). (10.1016/S0021-9258(17)40526-6) / J BIOL CHEM (1977)
  49. KAERLEIN, M, PHOSPHORYLATION OF RIBOSOMAL-PROTEINS IN HELA-CELLS INFECTED WITH VACCINIA VIRUS, NATURE 259: 150 (1976). (10.1038/259150a0) / NATURE (1976)
  50. KATZ, B, JOURNAL OF PHYSIOLOGY-LONDON 192: 407 (1967). (10.1113/jphysiol.1967.sp008307) / JOURNAL OF PHYSIOLOGY-LONDON (1967)
  51. KEBABIAN, J.W., MUSCARINIC CHOLINERGIC REGULATION OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE IN AUTONOMIC GANGLIA - POSSIBLE ROLE IN SYNAPTIC TRANSMISSION, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 193: 474 (1975). / JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1975)
  52. KELLER, R.K., PROTEIN-KINASES OF CHICK OVIDUCT - STUDY OF CYTOPLASMIC AND NUCLEAR ENZYMES, BIOCHEMISTRY 15: 1958 (1976). (10.1021/bi00654a025) / BIOCHEMISTRY (1976)
  53. KIRCHBERGER, M.A., DECREASE IN CALCIUM-TRANSPORT ASSOCIATED WITH PHOSPHOPROTEIN PHOSPHATASE-CATALYZED DEPHOSPHORYLATION OF CARDIAC SARCOPLASMIC-RETICULUM, JOURNAL OF CYCLIC NUCLEOTIDE RESEARCH 3: 45 (1977). / JOURNAL OF CYCLIC NUCLEOTIDE RESEARCH (1977)
  54. KRAMER, G, SPECIFICITY OF PROTEIN-KINASE ACTIVITY ASSOCIATED WITH HEMIN-CONTROLLED REPRESSOR OF RABBIT RETICULOCYTE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3078 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  55. KREBS, E.G., CURRENT TOPICS IN CELLULAR REGULATION 5: 99 (1972). (10.1016/B978-0-12-152805-8.50010-1) / CURRENT TOPICS IN CELLULAR REGULATION (1972)
  56. KREBS, E.G., PROTEIN PHOSPHORYLAT 5: 31 (1973). / PROTEIN PHOSPHORYLAT (1973)
  57. KRUEGER, B.K., DEPOLARIZATION-INDUCED PHOSPHORYLATION OF SPECIFIC PROTEINS, MEDIATED BY CALCIUM-ION INFLUX, IN RAT-BRAIN SYNAPTOSOMES, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 2764 (1977). (10.1016/S0021-9258(17)40523-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
  58. KRUH, J, EFFECT OF TRIIODOTHYRONINE ON RAT-LIVER CHROMATIN PROTEIN KINASE, EUROPEAN JOURNAL OF BIOCHEMISTRY 62: 109 (1976). (10.1111/j.1432-1033.1976.tb10103.x) / EUROPEAN JOURNAL OF BIOCHEMISTRY (1976)
  59. KUHN, H, PHOSPHORYLATION OF RHODOPSIN IN BOVINE PHOTORECEPTOR MEMBRANES - DARK REACTION AFTER ILLUMINATION, BIOCHEMISTRY 12: 2495 (1973). (10.1021/bi00737a020) / BIOCHEMISTRY (1973)
  60. KUHN, H, LIGHT-DEPENDENT PHOSPHORYLATION OF RHODOPSIN IN LIVING FROGS, NATURE 250: 588 (1974). (10.1038/250588a0) / NATURE (1974)
  61. KUMON, A, MODE OF ACTION OF ADENOSINE 3',5'-CYCLIC PHOSPHATE ON PROTEIN KINASE FROM RAT LIVER, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 41: 1290 (1970). (10.1016/0006-291X(70)90228-7) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1970)
  62. KUO, J.F., CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES .6. ISOLATION AND PARTIAL PURIFICATION OF A PROTEIN KINASE ACTIVATED BY GUANOSINE 3',5'-MONOPHOSPHATE, JOURNAL OF BIOLOGICAL CHEMISTRY 245: 2493 (1970). (10.1016/S0021-9258(18)63097-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1970)
  63. KUO, J.F., CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES .9. PARTIAL PURIFICATION AND SOME PROPERTIES OF GUANOSINE 3',5'-MONOPHOSPHATE-DEPENDENT AND ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASES FROM VARIOUS TISSUES AND SPECIES OF ARTHROPODA, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 7159 (1971). (10.1016/S0021-9258(19)45868-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1971)
  64. KUO, J.F., CHANGES IN RELATIVE LEVELS OF GUANOSINE-3'-5'-MONOPHOSPHATE-DEPENDENT AND ADENOSINE-3'-5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASES IN LUNG, HEART, AND BRAIN OF DEVELOPING GUINEA-PIGS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 2256 (1975). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1975)
  65. KUO, J.F., CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES .4. WIDESPREAD OCCURRENCE OF ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF ANIMAL KINGDOM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 64: 1349 (1969). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1969)
  66. LAGNADO, J.R., POSSIBLE SIGNIFICANCE OF ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE-STIMULATED PROTEIN KINASE-ACTIVITY ASSOCIATED WITH PURIFIED MICROTUBULAR PROTEIN PREPARATIONS FROM MAMMALIAN BRAIN, BIOCHEMICAL JOURNAL 128: P95 (1972). / BIOCHEMICAL JOURNAL (1972)
  67. LANGAN, T.A., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 3: 99 (1973). / ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH (1973)
  68. LARAIA, P.J., ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT MEMBRANE PHOSPHORYLATION - POSSIBLE MECHANISM FOR CONTROL OF MICROSOMAL CALCIUM-TRANSPORT IN HEART-MUSCLE, CIRCULATION RESEARCH 35: 298 (1974). (10.1161/01.RES.35.2.298) / CIRCULATION RESEARCH (1974)
  69. LARNER, J, CURRENT TOPICS CELLU 3: 195 (1971). (10.1016/B978-0-12-152803-4.50010-5) / CURRENT TOPICS CELLU (1971)
  70. LEBLEU, B, INTERFERON, DOUBLE-STRANDED-RNA, AND PROTEIN-PHOSPHORYLATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3107 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  71. LEE, T.P., ROLE OF MUSCARINIC CHOLINERGIC RECEPTORS IN REGULATION OF GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE CONTENT IN MAMMALIAN BRAIN, HEART-MUSCLE, AND INTESTINAL SMOOTH MUSCLE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 3287 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
  72. LINCOLN, T.M., GUANOSINE 3'=5'-CYCLIC MONOPHOSPHATE BINDING-PROTEINS IN RAT TISSUES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 2559 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  73. Liu A. Y.-C. in preparation.
  74. 10.1073/pnas.71.10.3869
  75. 10.1073/pnas.73.2.568
  76. LLOYD, T, EVIDENCE FOR LACK OF DIRECT PHOSPHORYLATION OF BOVINE CAUDATE TYROSINE-HYDROXYLASE FOLLOWING ACTIVATION BY EXPOSURE TO ENZYMATIC PHOSPHORYLATING CONDITIONS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 66: 907 (1975). (10.1016/0006-291X(75)90726-3) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1975)
  77. LOVENBERG, W, ATP, CYCLIC-AMP, AND MAGNESIUM INCREASE AFFINITY OF RAT STRIATAL TYROSINE-HYDROXYLASE FOR ITS COFACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 2955 (1975). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1975)
  78. MALLER, J.L., PROGESTERONE-STIMULATED MEIOTIC CELL-DIVISION IN XENOPUS OOCYTES - INDUCTION BY REGULATORY SUBUNIT AND INHIBITION BY CATALYTIC SUBUNIT OF ADENOSINE 3'-5'-MONOPHOSPHATE-DEPENDENT PROTEIN-KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 1712 (1977). (10.1016/S0021-9258(17)40606-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
  79. 10.1126/science.178.4058.310
  80. MIYAMOTO, E, DISSOCIATION AND CONCOMITANT ACTIVATION OF ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE BY HISTONE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 44: 305 (1971). (10.1016/0006-291X(71)90600-0) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1971)
  81. MORGENROTH, V.H., EVIDENCE FOR INVOLVEMENT OF PROTEIN KINASE IN ACTIVATION BY ADENOSINE 3'-5'-MONOPHOSPHATE OF BRAIN TYROSINE 3-MONOOXYGENASE, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 1946 (1975). (10.1016/S0021-9258(19)41787-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1975)
  82. MURTHY, L.D., EFFECTS OF HYDROCORTISONE UPON METABOLISM OF HISTONES IN RAT LIVER, BIOCHIMICA ET BIOPHYSICA ACTA 199: 500 (1970). (10.1016/0005-2787(70)90092-4) / BIOCHIMICA ET BIOPHYSICA ACTA (1970)
  83. NAKAZAWA, K, PARTIAL-PURIFICATION AND PROPERTIES OF GUANOSINE 3' - 5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE FROM PIG LUNG, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 7415 (1975). (10.1016/S0021-9258(19)40960-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1975)
  84. NAWRATH, H, DOES CYCLIC-GMP MEDIATE NEGATIVE INOTROPIC EFFECT OF ACETYLCHOLINE IN HEART, NATURE 267: 72 (1977). (10.1038/267072a0) / NATURE (1977)
  85. NIMMO, H.G., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 8: 145 (1977). / ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH (1977)
  86. ODEA, R.F., CATECHOLAMINE-STIMULATED CYCLIC-GMP ACCUMULATION IN RAT PINEAL - APPARENT PRESYNAPTIC SITE OF ACTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3398 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  87. PATRICK, R.L., STIMULATION OF SYNAPTOSOMAL DOPAMINE SYNTHESIS BY VERATRIDINE, NATURE 250: 737 (1974). (10.1038/250737a0) / NATURE (1974)
  88. PERRY, S.V., PROCEEDINGS OF THE FEDERATION OF THE EUROPEAN BIOCHEMICAL SOCIETIES 31: 163 (1975). / PROCEEDINGS OF THE FEDERATION OF THE EUROPEAN BIOCHEMICAL SOCIETIES (1975)
  89. POMERANTZ, A.H., PHOTOAFFINITY LABELING OF A PROTEIN KINASE FROM BOVINE BRAIN WITH 8-AZIDOADENOSINE 3',5'-MONOPHOSPHATE, BIOCHEMISTRY 14: 3858 (1975). (10.1021/bi00688a019) / BIOCHEMISTRY (1975)
  90. RANGELALDAO, R, DISSOCIATION AND REASSOCIATION OF PHOSPHORYLATED AND NON-PHOSPHORYLATED FORMS OF ADENOSINE 3'-5'-MONOPHOSPHATE-DEPENDENT PROTEIN-KINASE FROM BOVINE CARDIAC-MUSCLE, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 3375 (1976). (10.1016/S0021-9258(17)33447-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1976)
  91. RANU, R.S., REGULATION OF PROTEIN-SYNTHESIS IN RABBIT RETICULOCYTE LYSATES - PURIFICATION AND INITIAL CHARACTERIZATION OF CYCLIC 3'-5'-AMP INDEPENDENT PROTEIN-KINASE OF HEME-REGULATED TRANSLATIONAL INHIBITOR (PHOSPHORYLATION OF MET-TRNAF BINDING FACTOR), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 4349 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
  92. REIMANN, E.M., SEPARATION OF REGULATORY AND CATALYTIC SUBUNITS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE(S) OF RABBIT SKELETAL MUSCLE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42: 187 (1971). (10.1016/0006-291X(71)90086-6) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1971)
  93. ROBERTS, W.K., INTERFERON-MEDIATED PROTEIN-KINASE AND LOW-MOLECULAR-WEIGHT INHIBITOR OF PROTEIN-SYNTHESIS, NATURE 264: 477 (1976). (10.1038/264477a0) / NATURE (1976)
  94. ROQUES, M, LIVER PROTEIN-KINASE ACTIVITY AND TRIIODOTHYRONINE, ENDOCRINOLOGY 100: 967 (1977). (10.1210/endo-100-4-967) / ENDOCRINOLOGY (1977)
  95. ROSENFELD, M.G., STEROID HORMONES - EFFECTS ON ADENYL CYCLASE ACTIVITY AND ADENOSINE 3',5'-MONOPHOSPHATE IN TARGET TISSUES, SCIENCE 168: 253 (1970). (10.1126/science.168.3928.253) / SCIENCE (1970)
  96. ROSS, P.S., REGULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES IN CULTURED HEPATOMA-CELLS BY DEXAMETHASONE AND N-6, O-2'-DIBUTYRYL ADENOSINE 3'-5'-MONOPHOSPHATE, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 1448 (1977). (10.1016/S0021-9258(17)40677-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
  97. RUBIN, C.S., PROTEIN PHOSPHORYLATION, ANNUAL REVIEW OF BIOCHEMISTRY 44: 831 (1975). (10.1146/annurev.bi.44.070175.004151) / ANNUAL REVIEW OF BIOCHEMISTRY (1975)
  98. Rudolph S. A. Coupled Transport Phenomena in Cells and Tissues (1977).
  99. RUDOLPH, S.A., REGULATION OF PROTEIN PHOSPHORYLATION AND MEMBRANE-PERMEABILITY BY BETA-ADRENERGIC AGENTS AND CYCLIC ADENOSINE 3'-5'-MONOPHOSPHATE IN AVIAN ERYTHROCYTE, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 5684 (1974). (10.1016/S0021-9258(20)79781-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1974)
  100. SAHIB, M.K., ROLE OF CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE IN INDUCTION OF HEPATIC ENZYMES .3. INTERACTION OF HYDROCORTISONE AND N6, O2'-DIBUTYRYL CYCLIC ADENOSINE 3',5'-MONO-PHOSPHATE IN INDUCTION OF TYROSINE AMINOTRANSFERASE IN CULTURED H-4-11-E HEPATOMA CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 4539 (1971). (10.1016/S0021-9258(18)62045-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1971)
  101. Schlichter D. in preparation.
  102. SEN, A, SPECIFIC BINDING OF TYPE-C VIRAL CORE PROTEIN-P12 WITH PURIFIED VIRAL-RNA, CELL 7: 21 (1976). (10.1016/0092-8674(76)90251-8) / CELL (1976)
  103. SEN, A, PHOSPHORYLATION OF MURINE TYPE-C VIRAL P12 PROTEINS REGULATES THEIR EXTENT OF BINDING TO HOMOLOGOUS VIRAL-RNA, CELL 10: 489 (1977). / CELL (1977)
  104. SENFT, G, DIABETOLOGIA 4: 330 (1968). (10.1007/BF01211767) / DIABETOLOGIA (1968)
  105. Shulman H. in preparation..
  106. SHULTZ, G, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 1721 (1973). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1973)
  107. SILBERSTEIN, H, PURIFICATION AND PROPERTIES OF A VIRION PROTEIN-KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 3176 (1976). (10.1016/S0021-9258(17)33516-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1976)
  108. SILBERSTEIN, H, CHARACTERIZATION OF A VIRION PROTEIN-KINASE AS A VIRUS-SPECIFIED ENZYME, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 3185 (1976). (10.1016/S0021-9258(17)33517-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1976)
  109. SLOBODA, R.D., CYCLIC AMP-DEPENDENT ENDOGENOUS PHOSPHORYLATION OF A MICROTUBULE-ASSOCIATED PROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 177 (1975). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1975)
  110. SOIFER, D, ENZYMATIC-ACTIVITY IN TUBULIN PREPARATIONS .1. INTRINSIC PROTEIN KINASE-ACTIVITY IN LYOPHILIZED PREPARATIONS OF TUBULIN FROM PORCINE BRAIN, BIOCHIMICA ET BIOPHYSICA ACTA 271: 182 (1972). (10.1016/0005-2795(72)90146-8) / BIOCHIMICA ET BIOPHYSICA ACTA (1972)
  111. SOIFER, D, CYCLIC-AMP REGULATION OF INTRINSIC PROTEIN KINASE-ACTIVITY OF MICROTUBULE PROTEIN FROM PORCINE BRAIN, JOURNAL OF GENERAL PHYSIOLOGY 61: 265 (1973). / JOURNAL OF GENERAL PHYSIOLOGY (1973)
  112. STEINBERG, D, ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 7: 157 (1976). / ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH (1976)
  113. 10.1126/science.163488
  114. STONER, J, GUANOSINE CYCLIC 3', 5'-MONOPHOSPHATE AND GUANYLATE CYCLASE ACTIVITY IN GUINEA-PIG LUNG - EFFECTS OF ACETYLCHOLINE AND CHOLINESTERASE-INHIBITORS, MOLECULAR PHARMACOLOGY 10: 155 (1974). / MOLECULAR PHARMACOLOGY (1974)
  115. STUDY, R.E., TRANSACTIONS OF THE AMERICAN SOCIETY FOR NEUROCHEMISTRY: 264 (1977). / TRANSACTIONS OF THE AMERICAN SOCIETY FOR NEUROCHEMISTRY (1977)
  116. TADA, M, STIMULATION OF CALCIUM-TRANSPORT IN CARDIAC SARCOPLASMIC-RETICULUM BY ADENOSINE 3'-5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 6174 (1974). (10.1016/S0021-9258(19)42237-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1974)
  117. TADA, M, PHOSPHORYLATION OF A 22,000-DALTON COMPONENT OF CARDIAC SARCOPLASMIC-RETICULUM BY ADENOSINE 3'-5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 2640 (1975). (10.1016/S0021-9258(19)41650-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1975)
  118. TAKAI, Y, GUANOSINE 3'-5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE FROM BOVINE CEREBELLUM - PURIFICATION AND CHARACTERIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 4690 (1975). (10.1016/S0021-9258(19)41356-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1975)
  119. TAO, M, MECHANISM OF ACTIVATION BY ADENOSINE 3' - 5'-CYCLIC MONOPHOSPHATE OF A PROTEIN PHOSPHOKINASE FROM RABBIT RETICULOCYTES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 408 (1970). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1970)
  120. THOMPSON, E.B., MECHANISM OF ACTION OF GLUCOCORTICOIDS, METABOLISM-CLINICAL AND EXPERIMENTAL 23: 159 (1974). (10.1016/0026-0495(74)90113-9) / METABOLISM-CLINICAL AND EXPERIMENTAL (1974)
  121. TRAUGH, J.A., FACTORS INVOLVED IN INITIATION OF HEMOGLOBIN SYNTHESIS CAN BE PHOSPHORYLATED INVITRO, NATURE 263: 163 (1976). (10.1038/263163a0) / NATURE (1976)
  122. TSIAPALIS, C.M., CHEMICAL MODIFICATION OF DNA-POLYMERASE PHOSPHOPROTEIN FROM AVIAN-MYELOBLASTOSIS VIRUS, NATURE 266: 27 (1977). (10.1038/266027a0) / NATURE (1977)
  123. UEDA, T, ADENOSINE 3'-5'-MONOPHOSPHATE-REGULATED PHOSPHOPROTEIN SYSTEM OF NEURONAL MEMBRANES .1. SOLUBILIZATION, PURIFICATION, AND SOME PROPERTIES OF AN ENDOGENOUS PHOSPHOPROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 5155 (1977). (10.1016/S0021-9258(17)40170-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
  124. WALSH, D.A., AN ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDANT PROTEIN KINASE FROM RABBIT SKELETAL MUSCLE, JOURNAL OF BIOLOGICAL CHEMISTRY 243: 3763 (1968). (10.1016/S0021-9258(19)34204-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1968)
  125. WALTER, U, IDENTIFICATION, CHARACTERIZATION, AND QUANTITATIVE MEASUREMENT OF CYCLIC-AMP RECEPTOR PROTEINS IN CYTOSOL OF VARIOUS TISSUES USING A PHOTOAFFINITY LIGAND, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 6494 (1977). (10.1016/S0021-9258(17)39985-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1977)
  126. WALTON, K.G., REGULATION OF PROTEIN PHOSPHORYLATION AND SODIUM-TRANSPORT IN TOAD BLADDER, JOURNAL OF GENERAL PHYSIOLOGY 65: 153 (1975). (10.1085/jgp.65.2.153) / JOURNAL OF GENERAL PHYSIOLOGY (1975)
  127. Weiner, N., Neuroregulalors and Psychialric Disorders: 75 (1977). / Neuroregulalors and Psychialric Disorders (1977)
  128. WEISS, B, GONADAL HORMONES AS REGULATORS OF PINEAL ADENYL CYCLASE ACTIVITY, ENDOCRINOLOGY 87: 527 (1970). (10.1210/endo-87-3-527) / ENDOCRINOLOGY (1970)
  129. WOODY, C. D., FEDERATION PROCEEDINGS 35: 641 (1976). / FEDERATION PROCEEDINGS (1976)
  130. YAMASHITA, K, ELEVATION OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE LEVELS IN DOG THYROID SLICES CAUSED BY ACETYLCHOLINE AND SODIUM-FLUORIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 7062 (1972). (10.1016/S0021-9258(19)44693-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1972)
  131. ZILBERSTEIN, A, SPECIFIC PHOSPHORYLATION INVITRO OF A PROTEIN ASSOCIATED WITH RIBOSOMES OF INTERFERON-TREATED MOUSE L CELLS, FEBS LETTERS 68: 119 (1976). (10.1016/0014-5793(76)80418-8) / FEBS LETTERS (1976)
Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 12:35 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:25 a.m.)
Indexed 1 month, 2 weeks ago (July 11, 2025, 6:22 a.m.)
Issued 47 years, 7 months ago (Jan. 13, 1978)
Published 47 years, 7 months ago (Jan. 13, 1978)
Published Print 47 years, 7 months ago (Jan. 13, 1978)
Funders 0

None

@article{Greengard_1978, title={Phosphorylated Proteins as Physiological Effectors: Protein phosphorylation may be a final common pathway for many biological regulatory agents.}, volume={199}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.22932}, DOI={10.1126/science.22932}, number={4325}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Greengard, Paul}, year={1978}, month=jan, pages={146–152} }