DOI: 10.1126/science.228394. The Dielectric Constant of Phospholipid Bilayers and the Permeability of Membranes to Ions

The Dielectric Constant of Phospholipid Bilayers and the Permeability of Membranes to Ions

10.1126/science.228394

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The Born charging equation predicts that the permeability of a phospholipid bilayer membrane to ions should depend markedly on the dielectric constant of the membrane. Increasing the dielectric constant of an artificial bilayer increases its permeability to perchlorate or thiocyanate by a factor of 1000, to a value comparable to that of mitochondrial membranes.

Bibliography

Dilger, J. P., McLaughlin, S. G. A., McIntosh, T. J., & Simon, S. A. (1979). The Dielectric Constant of Phospholipid Bilayers and the Permeability of Membranes to Ions. Science, 206(4423), 1196â1198.

Authors 4

James P. Dilger (first)
Stuart G. A. McLaughlin (additional)
Thomas J. McIntosh (additional)
Sidney A. Simon (additional)

References 15 Referenced 128

BERRY E COMMUNICATION.
DILGER, J, PROTON TRANSPORT THROUGH MEMBRANES INDUCED BY WEAK ACIDS - STUDY OF 2 SUBSTITUTED BENZIMIDAZOLES, JOURNAL OF MEMBRANE BIOLOGY 46: 359 (1979). (10.1007/BF01868755) / JOURNAL OF MEMBRANE BIOLOGY (1979)
FETTIPLACE, R, THICKNESS, COMPOSITION AND STRUCTURE OF SOME LIPID BILAYERS AND NATURAL MEMBRANES, JOURNAL OF MEMBRANE BIOLOGY 5: 277 (1971). (10.1007/BF01870555) / JOURNAL OF MEMBRANE BIOLOGY (1971)
LEBLANC, O.H., EFFECT OF UNCOUPLERS OF OXIDATIVE PHOSPHORYLATION ON LIPID BILAYER MEMBRANES - CARBONYLCYANIDE META-CHLOROPHENYLHYDRAZONE, JOURNAL OF MEMBRANE BIOLOGY 4: 227 (1971). (10.1007/BF02431973) / JOURNAL OF MEMBRANE BIOLOGY (1971)
MCINTOSH, T.J., EFFECT OF CHOLESTEROL ON STRUCTURE OF PHOSPHATIDYLCHOLINE BILAYERS, BIOCHIMICA ET BIOPHYSICA ACTA 513: 43 (1978). (10.1016/0005-2736(78)90110-4) / BIOCHIMICA ET BIOPHYSICA ACTA (1978)
MCLAUGHLIN, S, CHAOTROPIC ANIONS AND SURFACE-POTENTIAL OF BILAYER MEMBRANES, BIOCHIMICA ET BIOPHYSICA ACTA 394: 304 (1975). (10.1016/0005-2736(75)90267-9) / BIOCHIMICA ET BIOPHYSICA ACTA (1975)
MONTAL, M, FORMATION OF BIMOLECULAR MEMBRANES FROM LIPID MONOLAYERS AND A STUDY OF THEIR ELECTRICAL PROPERTIES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 3561 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
MUELLER, P, RECONSTITUTION OF EXCITABLE CELL MEMBRANE STRUCTURE IN VITRO, CIRCULATION 26: 1167 (1962). (10.1161/01.CIR.26.5.1167) / CIRCULATION (1962)
10.1038/221844a0
PICKAR, A.D., TRANSPORT OF OPPOSITELY CHARGED LIPOPHILIC PROBE IONS IN LIPID BILAYER MEMBRANES HAVING VARIOUS STRUCTURES, JOURNAL OF MEMBRANE BIOLOGY 44: 353 (1978). (10.1007/BF01944229) / JOURNAL OF MEMBRANE BIOLOGY (1978)
REQUENA, J, VANDERWAALS FORCES IN OIL-WATER SYSTEMS FROM STUDY OF THIN LIPID FILMS .2. DEPENDENCE OF VANDERWAALS FREE-ENERGY OF THINNING ON FILM COMPOSITION AND STRUCTURE, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 347: 161 (1975). / PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (1975)
ROSEMAN, M.A., PROPERTIES OF SONICATED VESICLES OF 3 SYNTHETIC PHOSPHOLIPIDS, CHEMISTRY AND PHYSICS OF LIPIDS 21: 205 (1978). (10.1016/0009-3084(78)90068-3) / CHEMISTRY AND PHYSICS OF LIPIDS (1978)
SIMON, S.A., CALORIMETRIC AND MONOLAYER INVESTIGATION OF INFLUENCE OF IONS ON THERMODYNAMIC PROPERTIES OF PHOSPHATIDYLCHOLINE, BIOCHIMICA ET BIOPHYSICA ACTA 375: 317 (1975). (10.1016/0005-2736(75)90350-8) / BIOCHIMICA ET BIOPHYSICA ACTA (1975)
SMALL, D.M., PHASE EQUILIBRIA AND STRUCTURE OF DRY AND HYDRATED EGG LECITHIN, JOURNAL OF LIPID RESEARCH 8: 551 (1967). (10.1016/S0022-2275(20)38874-X) / JOURNAL OF LIPID RESEARCH (1967)
WHITE, S.H., FORMATION OF SOLVENT-FREE BLACK LIPID BILAYER MEMBRANES FROM GLYCERYL MONOOLEATE DISPERSED IN SQUALENE, BIOPHYSICAL JOURNAL 23: 337 (1978). (10.1016/S0006-3495(78)85453-8) / BIOPHYSICAL JOURNAL (1978)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:39 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 3:18 a.m.)
Indexed	2 days, 23 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued	45 years, 8 months ago (Dec. 7, 1979)
Published	45 years, 8 months ago (Dec. 7, 1979)
Published Print	45 years, 8 months ago (Dec. 7, 1979)

Funders 0

None

BibTeX

@article{Dilger_1979, title={The Dielectric Constant of Phospholipid Bilayers and the Permeability of Membranes to Ions}, volume={206}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.228394}, DOI={10.1126/science.228394}, number={4423}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Dilger, James P. and McLaughlin, Stuart G. A. and McIntosh, Thomas J. and Simon, Sidney A.}, year={1979}, month=dec, pages={1196–1198} }

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