DOI: 10.1126/science.2255914. Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase Activity

Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase Activity

10.1126/science.2255914

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL . The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL ( SCL interrupting locus), and the 5′ untranslated region of SCL . Similar to 1;14 translocations, this deletion disrupts the SCL 5′ regulatory region. This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin or a T cell receptor. Two other T cell lines, CEM and RPMI 8402, have essentially identical deletions. Thus, in lymphocytes, growth-affecting genes other than immune receptors risk rearrangements.

Bibliography

Aplan, P. D., Lombardi, D. P., Ginsberg, A. M., Cossman, J., Bertness, V. L., & Kirsch, I. R. (1990). Disruption of the Human SCL Locus by âIllegitimateâ V-(D)-J Recombinase Activity. Science, 250(4986), 1426â1429.

Authors 6

Peter D. Aplan (first)
Donald P. Lombardi (additional)
Ann M. Ginsberg (additional)
Jeffrey Cossman (additional)
Virginia L. Bertness (additional)
Ilan R. Kirsch (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:41 a.m.)
Indexed	2 months ago (June 26, 2025, 2:25 p.m.)
Issued	34 years, 8 months ago (Dec. 7, 1990)
Published	34 years, 8 months ago (Dec. 7, 1990)
Published Print	34 years, 8 months ago (Dec. 7, 1990)

Funders 0

None

BibTeX

@article{Aplan_1990, title={Disruption of the Human SCL Locus by “Illegitimate” V-(D)-J Recombinase Activity}, volume={250}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2255914}, DOI={10.1126/science.2255914}, number={4986}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Aplan, Peter D. and Lombardi, Donald P. and Ginsberg, Ann M. and Cossman, Jeffrey and Bertness, Virginia L. and Kirsch, Ilan R.}, year={1990}, month=dec, pages={1426–1429} }

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