DOI: 10.1126/science.2255909. Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection

Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection

10.1126/science.2255909

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The mammalian olfactory system may transduce odorant information via a G protein-mediated adenosine 3′,5′-monophosphate (cAMP) cascade. A newly discovered adenylyl cyclase, termed type III, has been cloned, and its expression was localized to olfactory neurons. The type III protein resides in the sensory neuronal cilia, which project into the nasal lumen and are accessible to airborne odorants. The enzymatic activity of the type III adenylyl cyclase appears to differ from nonsensory cyclases. The large difference seen between basal and stimulated activity for the type III enzyme could allow considerable modulation of the intracellular cAMP concentration. This property may represent one mechanism of achieving sensitivity in odorant perception.

Bibliography

Bakalyar, H. A., & Reed, R. R. (1990). Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection. Science, 250(4986), 1403â1406.

Authors 2

Heather A. Bakalyar (first)
Randall R. Reed (additional)

References 29 Referenced 544

BAKALYAR H unpublished data.
Beets, M. G. J., Fragrance Chemistry: The Science of Sense and Smell: 77 (1982). / Fragrance Chemistry: The Science of Sense and Smell (1982)
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10.1126/science.2405488
GORMAN, C.M., DNA AND PROTEIN ENGINEERING TECHNIQUES 2: 3 (1990). / DNA AND PROTEIN ENGINEERING TECHNIQUES (1990)
GRAZIADEI, GAM, NEUROGENESIS AND NEURON REGENERATION IN THE OLFACTORY SYSTEM OF MAMMALS .2. DEGENERATION AND RECONSTITUTION OF THE OLFACTORY SENSORY NEURONS AFTER AXOTOMY, JOURNAL OF NEUROCYTOLOGY 8: 197 (1979). (10.1007/BF01175561) / JOURNAL OF NEUROCYTOLOGY (1979)
Harlow E. Antibodies: A Laboratory Manual (1988).
JONES, D.T., COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 53: 349 (1988). (10.1101/SQB.1988.053.01.042) / COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (1988)
10.1016/S0021-9258(18)47929-X
JONES, D.T., BIOCHEMICAL-CHARACTERIZATION OF 3 STIMULATORY GTP-BINDING PROTEINS - THE LARGE AND SMALL FORMS OF GS AND THE OLFACTORY-SPECIFIC G-PROTEIN, GOLF, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 2671 (1990). (10.1016/S0021-9258(19)39853-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1990)
10.1126/science.2499043
KATAOKA, T, DNA-SEQUENCE AND CHARACTERIZATION OF THE S-CEREVISIAE GENE ENCODING ADENYLATE-CYCLASE, CELL 43: 493 (1985). (10.1016/0092-8674(85)90179-5) / CELL (1985)
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10.1016/0022-2836(82)90515-0
10.1038/227680a0
MARSHALL, M.S., AN ADENYLATE-CYCLASE FROM SACCHAROMYCES-CEREVISIAE THAT IS STIMULATED BY RAS PROTEINS WITH EFFECTOR MUTATIONS, MOLECULAR AND CELLULAR BIOLOGY 8: 52 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
MASSON, P, YEAST ADENYLATE-CYCLASE CATALYTIC DOMAIN IS CARBOXY TERMINAL, CURRENT GENETICS 10: 343 (1986). (10.1007/BF00418405) / CURRENT GENETICS (1986)
MENCO B COMMUNICATION.
10.1038/325442a0
10.1038/316255a0
PFEUFFER, E, OLFACTORY ADENYLYL CYCLASE - IDENTIFICATION AND PURIFICATION OF A NOVEL ENZYME FORM, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 18803 (1989). (10.1016/S0021-9258(18)51538-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1989)
10.1126/science.2848320
REED R.R. unpublished data.
Rhein, L. D., Proceedings of the National Academy of Sciences of the United States of America 77: 4412 (1980). / Proceedings of the National Academy of Sciences of the United States of America (1980)
Salomon, Y., Advatces in Cyclic Nucleotide Research 10: 35 (1979). / Advatces in Cyclic Nucleotide Research (1979)
Seamon, K. B., Proceedings of the National Academy of Sciences of the United States of America 78: 3363 (1981). / Proceedings of the National Academy of Sciences of the United States of America (1981)
10.1016/S0021-9258(18)66747-X
SOUTHERN, P.J., JOURNAL OF MOLECULAR AND APPLIED GENETICS 1: 327 (1982). / JOURNAL OF MOLECULAR AND APPLIED GENETICS (1982)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:41 a.m.)
Indexed	3 months ago (May 27, 2025, 2:03 a.m.)
Issued	34 years, 8 months ago (Dec. 7, 1990)
Published	34 years, 8 months ago (Dec. 7, 1990)
Published Print	34 years, 8 months ago (Dec. 7, 1990)

Funders 0

None

BibTeX

@article{Bakalyar_1990, title={Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection}, volume={250}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2255909}, DOI={10.1126/science.2255909}, number={4986}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Bakalyar, Heather A. and Reed, Randall R.}, year={1990}, month=dec, pages={1403–1406} }

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